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Axitinib (also known as AG-013736) is a small molecule tyrosine kinase inhibitor. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT (CD117). It has been shown to...

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.AZ628 is a new pan-Raf inhibitor for BRAF,...

AZ-191 is a potent and selective DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor (IC50 = 17 nM). AZ-191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B is...

AZ-304 is a potent, ATP-competitive dual BRAF kinase inhibitor that inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC₅₀s of 79 nM, 38 nM and 68 nM, respectively. In addition,...

AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor (IC₅₀ = 35 nM). Shows selectivity over 46 other kinases including aurora kinase B and Cdk1. AZ 3146 overrides spindle...

AZ-505 is a potent and highly selective inhibitor of SMYD2 (IC₅₀ = 0.12 μM) with potential anticancer activity. Displays >600-fold selectivity over other histone methyltransferases, such as SMYD3...

AZ-5104 is an active, demethylated metabolite of AZD-9291 (Cat.No.2674). It displays similar overall activity profile with AZD-9291, but is more potent against mutant EGFR forms, while hitting the...

AZ-6102 is a potent TNKS1/2 inhibitor (Tankyrase) that displays >100-fold selectivity against other poly (ADP-ribose) polymerase (PARP) family enzymes and inhibits Wnt pathway with IC₅₀ value of 5 nM...

AZ-7371 is a non-covalent inhibitor of decaprenylphosphoryl-D-ribose oxidase (DprE1) with an IC₅₀ value of 10 nM. It also inhibits PDE6 (IC₅₀ = 4 µM).AZ-7371 is a non-covalent inhibitor of...

AZ-960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM. AZ-960 induces growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1-infected T cells (MT-1...

AZ10417808 is a selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced...

AZ20 is a potent and selective inhibitor of ATR kinase with IC50 value of 5 nM.AZ20 is a potent and selective inhibitor of ATR kinase with IC50 value of 5 nM.B1724 | AZ20 DataSheetAlternate...

Azamulin is a derivative of the antibiotic pleuromutilin. It is a highly selective inhibitor of the CYP3A family (IC50 = 0.03-0.24 μM as reported in Stresser et al., DMD, January 2004 vol. 32 no. 1...

Azathioprine is a purine analog that displays immunosuppressive and anti-inflammatory properties. It serves as a prodrug for 6-mercaptopurine, which alters purine processing and DNA synthesis,...

AZD-0156 is an orally bioavailable Ataxia Telangiectasia Mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD-0156 targets and binds to ATM,...

AZD-1283 is a potent antagonist of the P2Y12 receptor. In a modified Folts model in dog, AZD-1283 dose-dependently induces increases in blood flow and inhibition of ADP-induced platelet aggregation...

AZD-1981 is a potent and selective antagonist of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2) with an IC₅₀ value of 4 nM; blocks functional responses...

AZD-2014 is a dual mTORC1/ mTORC2 inhibitor with potential antineoplastic activity.AZD-2014 is a dual mTORC1/ mTORC2 inhibitor with potential antineoplastic activity.9449 | AZD-2014...

AZD-2461 is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP1 and PARP2 with IC₅₀ values of 5 nM and 2 nM. It has lower affinity for P-glycoprotein and suppresses the development...

AZD3229 is a potent, pan-KIT mutant inhibitor that displays single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). It also inhibits PDGFR...

AZD-3463 is a potent ALK (Anaplastic Lymphoma Kinase)/IGFR1 dual inhibitor that displays ability to overcome acquired resistance to Crizotinib (Cat. No.1934).AZD-3463 is a potent ALK (Anaplastic...

AZD-3759 is a potent epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. AZD-3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of...

AZD-3965 is a potent and selective monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM; it is 6-fold selective over MCT2 and does not inhibit MCT4 even at 10 μM. AZD 3965...

AZD-4205 is a highly selective Janus Kinase 1 (JAK1) inhibitor with an IC₅₀ of 0.07 μM. It shows antitumor activity in combination with the EGFR inhibitor, osimertinib, in a preclinical...

AZD-4547 is a novel and selective inhibitor of the FGFR1, 2, and 3 tyrosine kinases. It binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways,...

AZD-4573 is a potent and highly selective CDK9 inhibitor (IC50 of

AZD-4635 is an orally available, small molecule adenosine A2A receptor antagonist. It reverses adenosine-mediated T-cell suppression and enhances antitumor immunity.AZD-4635 is an orally available,...

AZD-5069 is a potent and reversible CXCR2 chemokine receptor antagonist with potential anti-inflammatory and antineoplastic activities. Upon administration, CXC chemokine receptor 2 antagonist...

AZD-5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with a bivalent binding mode. AZD-5153 ligates two bromodomains in BRD4 simultaneously. Displays cellular and...

AZD5363, also known as Capivasertib, is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.AZD5363, also known as Capivasertib, is a potent pan-AKT...

AZD-5438 is a potent inhibitor of cyclin-dependent kinases (CDKs) (IC₅₀ values are 16, 6 and 20 nM for CDK1, 2, and 9, respectively). Displays antiproliferative activity in human tumor cell lines. It...

AZD-5582 is a potent IAP inhibitor that binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC₅₀ values of 15, 21, and 15 NM, respectively).AZD-5582 is a potent IAP inhibitor that binds...

AZD-5904 is a potent and irreversible inhibitor of human myeloperoxidase (MPO) (IC₅₀ = 140 nM). Displays similar potency in mouse and rat enzymes.AZD-5904 is a potent and irreversible inhibitor of...

AZD-6482 is a potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC₅₀ values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). It displays 80-fold...

AZD6738 is a potent ATR kinase inhibitor with IC₅₀ value of 1 nM against the isolated enzyme. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the...

AZD7762 is a potent, ATP-competitive, reversible, checkpoint kinase inhibitor with IC₅₀s at 5 nM and

AZD-8186 is a potent and selective PI3Kβ/δ inhibitor. Displays potential to reduce growth of tumors dependent on dysregulated PTEN for growth.AZD-8186 is a potent and selective PI3Kβ/δ inhibitor...

AZD-8931 is a potent, ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3 (the IC₅₀ values are 4 nM, 3 nM and 4 nM, respectively).AZD-8931 is a potent, ATP competitive...

AZD9291 is a potent, selective, and irreversible, third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It inhibits EGFR phosphorylation in EGFR-bearing cells...

AZD-9291 is a potent, third generation, mutant-selective EGFR tyrosine kinase inhibitor. It is effective against both EGFR-TKI sensitizing and resistance T790M mutations. Displays anticancer...

AZD-9468 | B3351Description: AZD-9468 (CXD101) is a potent histone deacetylase (HDAC) inhibitor with potential antineoplastic activity.Alternate Name/Synonyms:...

AZD1208 is a potent and highly selective pan-Pim Kinase inhibitor. It inhibits Pim-1,-2, and -3 kinases at

AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively.AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26...

Cell-permeable. A potent, highly selective and non-ATP competitive inhibitor of mitogen-activated protein kinase kinase 1/2 (MEK1/2) (IC₅₀ = 14 nM/L against purified MEK1). Displays antineoplastic...

A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC₅₀ of 0.8 nM. AZD8055 displays excellent selectivity (~ 1,000-fold) against all class I PI3K isoforms and other...

AZD8330 is an orally active, selective MEK inhibitor with an IC50 of 7 nM.AZD8330 is an orally active, selective MEK inhibitor with an IC50 of 7 nM.B1693 | AZD8330 DataSheetAlternate Name/Synonyms:...

AZD8835 is a potent and selective inhibitor of PI3Kδ and PI3Kα with IC50 of 5.7 nM and 6.2 nM, with selectivity against PI3Kβ (IC50 431 nM) and PI3Kγ (IC50 90 nM).AZD8835 is a potent and selective...

AZD9496 is a potent and orally bioavailable selective estrogen receptor down regulator (Ki=0.7 nM) and antagonist.AZD9496 is a potent and orally bioavailable selective estrogen receptor down...

Azeliragon is a potent RAGE (the receptor for advanced glycation end products) inhibitor. It has been evaluated for potential treatment for patients with mild-to-moderate Alzheimer's disease (AD)...

Azidothymidine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC₅₀ > 5...

Azithromycin is a macrolide antibiotic that inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram positive and negative bacteria. In vivo activity shows improved...

Azlocillin sodium is an acylampicillin that exhibits an extended-spectrum of activity and in vitro potency that is greater than that of the carboxy penicillins. Azlocillin is shown to be effective...

Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER...

Aztreonam is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the...

The gene for azurocidin is located on the short arm of chromosome 19 and is in a cluster with the genes for proteinase 3 and elastase. All three proteins are serine protease homologues; azurocidin,...

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC₅₀s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK respectively.B-Raf inhibitor 1 is a potent and selective B-Raf...

Oxalate oxidase is a member of the cupin superfamily. It catalyzes the breakdown of oxalate to hydrogen peroxide and carbon dioxide. Oxalate oxidase and oxalate decarboxylase are two similar enzymes...

­1,3­N­acetylglucosaminyltransferase 6 (3GnT6) transfers N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to N-acetylgalactosamine (GalNAc). 3GnT6 is also known as the core 3 synthase, because it...

1,4-galactosyltransferase 1 was the first mammalian glycosyltransferase to be isolated and cloned. 4GalT1 is a member of a homologous family of seven 1,4-galactosyltransferases, 4Gal-T1 – T7, that...

B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell...

5051 | BACE Antibody (CT) DataSheet

6651 | BACE1 Antibody DataSheet

6102 | BACE2/Asp1 Antibody DataSheet

6723 | BACE2C Antibody (CT) DataSheet

Bacitracin is a peptide antibiotic and an inhibitor of peptidoglycan synthesis. Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin is used to...

K511 | Bacterial Counting Colorimetric Assay Kit DataSheet

K309 | Bacterial Genomic DNA Isolation Kit DataSheet

Gor, also known as Glutathione oxido-reductase, belongs to the class-I pyridine nucleotide disulfide oxidoreductase family. The main function of this protein is to maintain high levels of reduced...

Malate dehydrogenase (MDH) belongs to the LDH/MDH superfamily and MDH type 1 family. This enzyme catalyzes the conversion of malate into oxaloacetate (using NAD+) and vice versa (reversible reaction)...

SurA is a periplasmic peptidyl-prolyl isomerase (PPIase) and chaperone of Escherichia coli and other Gram-negative bacteria. This protein is a major factor in the biogenesis of beta-barrel outer...

Bactericidal/permeability increasing protein (BPI) is a 456 residue protein which is part of the innate immune system. BPI was initially identified in neutrophils, but is found in other tissues...

3030 | Bad Antibody DataSheet

3005 | Bad monoclonal Antibody DataSheet

BAEE (N-α-Benzoyl-L-arginine ethyl ester) is a nonpeptide substrate of proteases and deiminases. It has been used as a substrate for the determination of trypsin activity. Additionally, BAEE has also...

Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn inhibitor with IC₅₀ values of 5.8 nM and 19 nM, respectively.Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn...

3203 | BAFF Antibody DataSheet

BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral...

Human BAFF (for B cell activating factor belonging to the TNF family) is a newly discovered novel ligand of the TNF family. BAFF plays an important role as co-stimulator of B cell proliferation and...

Rat BAFF (for B cell activating factor belonging to the TNF family) is a newly discovered novel ligand of the TNF family. BAFF plays an important role as co-stimulator of B cell proliferation and...

3578R | BAFF-R Antibody DataSheet

3578RBP | BAFF-R Blocking Peptide DataSheetAntibody Target: BAFF-R Accession #: XP_910762Gene ID: 631763Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3578 | BAFF-R Polyclonal Antibody DataSheet

K4181 | BAFF/CD257 Human Elisa Kit DataSheet

A highly potent and selective inhibitor of vacuolar H+-ATPases (V-ATPases) in vitro. It is effective in nanomolar concentrations in animal cells, plant cells and microorganisms; also selective over...

A potent, ATP-competitive, dual PI3K/PDK-1 inhibitor in vitro and in vivo (IC₅₀ = 56, 444, 34, 117 and 240 nM for PI3K p110-α ,β,d, γ, and PDK1 kinases, respectively). Displays anticancer properties...

BAIAP2 is a ubiquitous regulator of the actin cytoskeleton. Controlled by the Rho-family GTPases BAIAP2 facilitates filopodia development. BAIAP2 is expressed in the cytoplasm and binds small...

A potent inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Baicalein inhibits lipid peroxidation, as assessed by production of thiobarbituric acid (TBARS;...

Baicalin | B3372Description: Baicalin is a biologically active flavonoid compound that displays anti-inflammatory and anti-oxidant activity. Baicalin inhibits HIV-1 replication by blocking the...

3031 | BAK1 Antibody DataSheet

3031BP | BAK1 Blocking Peptide DataSheetAntibody Target: Bak1Accession #: Q16611Gene ID: 578Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

Isolated from plant Psoralea corylifolia. Acts as an inhibitor of protein tyrosine phosphatase 1B (PTB1B (IC₅₀ = 20.8±1.9 µM). Antioxidant and an inhibitor of mitochondrial lipid peroxidation. Also...

Cell-permeable. Balicatib is a potent human cathepsin K inhibitor in vitro (IC₅₀ = 1.4 nM) with a high selectivity against human cathepsins B, L, and S (> 4,800-fold, > 500-fold and > 65,000-fold,...

Balovaptan is a potent and selective vasopressin-1 receptor antagonistBalovaptan is a potent and selective vasopressin-1 receptor antagonistB2534 | Balovaptan DataSheetAlternate Name/Synonyms:...

Baloxavir marboxil is a prodrug that is metabolised to the active form baloxavir acid also known as S‐033447. S‐033447 is a small molecule inhibitor of the cap‐dependent endonuclease of influenza A...

Bambuterol is a prodrug for terbutaline that acts as a long-acting β-adrenoceptor agonist. Bambuterol is converted to terbutaline by butyrylcholinesterases in the liver and plasma. Acts as a...

A cell-permeable, selective chelator of intracellular calcium stores. BAPTA is105-fold greater affinity for Ca2+ than for Mg2+. Inhibits thapsigargin-induced apoptosis in rat thymocytes.BAPTA AM is a...

BAR-501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. It effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with an EC₅₀ of 1 μM. Exposure...

BAR-502 is a dual FXR (farnesoid X receptor) and GPBAR1 (G protein-coupled bile acid-activated receptor) agonist. BAR-502 promotes browning of white adipose tissue and reverses liver steatosis and...

A1057 | BAR2 Antibody (S261) DataSheet

3768 | BARD1 Antibody DataSheet