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Bardoxolone is a synthetic oleanane triterpenoid that inhibits cellular iNOS production when stimulated by IFNg, TNF-α and IL-1. It is Reata’s investigational lead molecule for CKD (chronic kidney...

Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM, respectively. Baricitinib is ~70 and ~10-fold selective versus JAK3 and Tyk2, with no inhibition to...

Baricitinib is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM, respectively. Baricitinib is ~70 and ~10-fold selective versus JAK3 and Tyk2, with no inhibition to c-Met and...

K1222 | BasicExoRNA Basic RNA extraction kit Pre-isolated exosomes, 25 reactions DataSheet

Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and...

A potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins. BAM7 triggers in vitro BAX...

3032 | Bax Antibody DataSheet

3032BP | Bax Blocking Peptide DataSheetAntibody Target: Bax Accession #: L22473Gene ID: 581Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

E4511 | BAX Human Elisa Kit DataSheet

E4512 | BAX Mouse Elisa Kit DataSheet

E4513 | BAX Rat Elisa Kit DataSheet

Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation...

An irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It prevents gene expression that is regulated through the...

BAY 41-2272 is a soluble guanylyl cyclase (sGC) activator; acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC₅₀ = 36 nM) and...

BAY 43-9006 (Sorafenib) is an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ =...

A free base form of BAY 43-9006 (Sorafenib) (Cat. No. 1594-25,100). Acts as an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including...

BAY 57-1293 is a potent helicase primase inhibitor. It inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the...

A free base form of the nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator BAY 58-2667 hydrochloride (Cat. No. 2027).BAY 58-2667 is a nitric oxide (NO)- and heme-independent...

A nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Displays potent cardiovascular effects. Improves cardiopulmonary hemodynamics in patients with acute decompensated heart...

BAY 59-3074 is a partial agonist of CB1/CB2 receptor with Ki values of 48.3 nM and 45.5 nM for human CB1/CB2 receptors, respectively. It displays CB1 agonist activity in in vivo studies and displays...

Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk,...

BAY 63-2521 is a potent activator of soluble guanylate cyclase (sGC).BAY 63-2521 is a potent activator of soluble guanylate cyclase (sGC).2644 | BAY 63-2521 DataSheetAlternate Name/Synonyms: Methyl...

BAY 80-6946 is a highly selective and potent pan-class I PI3K inhibitor with sub-nanomolar IC₅₀s against PI3Kα and PI3Kδ. BAY 80-6946 displays preferential inhibition (about 10-fold) of AKT...

Molidustat (BAY-85-3934) is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells without...

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It inhibits HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer...

BAY-1125976 is a potent and selective allosteric AKT1/2 inhibitor that displays high efficacy on AKT signaling-dependent tumor growth in mouse models. It inhibits Akt1 and Akt2 activity with IC50...

BAY-1217389 is a potent, and selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, BAY-1217389 selectively...

BAY-1436032 is a potent and highly selective inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H,...

BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. Displays excellent selectivity over a panel of 395 kinases. BAY...

BAY-1895344, an orally available, potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor (IC₅₀ = 7 nM). Displays potent anti-tumor efficacy in monotherapy and strong combination...

BAY-2402234 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 1.2 nM). It induces upregulation of the cell differentiation marker CD11b in MOLM-13 and HEL acute myeloid leukemia...

BAY-598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC₅₀ values are 27 and 58 nM for biochemical and cellular activity assays, respectively). It displays...

BAY-677 is a negative control for BAY-678. BAY-678 is a potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 20 nM. The S-enantiomer BAY-677 inhibits HNE...

BAY-678 is a potent, selective, cell-permeable inhibitor of human neutrophil elastase (HNE).The activity of HNE is increased in inflammatory diseases. BAY-678 shows Ki values of 15 nM and 600 nM for...

BAY-8002 is a potent dual MCT1/2 (Monocarboxylate Transporter ½) inhibitor. Inhibits cellular SNARF-5 fluorescence change (IC₅₀ = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases...

BAY-876 is a highly selective GLUT1 inhibitor (IC₅₀ = 2 mM). Displays good metabolic stability in vitro and high oral bioavailability in vivo.BAY-876 is a highly selective GLUT1 inhibitor (IC₅₀ = 2...

BAZ2-ICR is a small molecule inhibitor of BAZ2A (Kd = 109 nM; IC₅₀ = 130 nM) and BAZ2B (Kd = 170 nM; IC50 = 180 nM) bromodomains. It displays 15-fold selectivity for binding BAZ2A/B over CECR2 and...

Bazedoxifene acetate (TSE-424 acetate) is a nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene acetate can be used...

BB-Cl-Amidine is a pan-peptidylarginine deiminase (PAD) inhibitor. Peptidylarginine deiminase catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BB-Cl-Amidine is a derivative...

BBT-594 is a potent and selective RET and JAK2 inhibitor. It impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. Displays potent anticancer activity.BBT-594 is a potent and...

BC-1618 is a potent Fbxo48 inhibitory compound that stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). Fbxo48 and was much more potent than...

BCA is a Cu(I)-specific colorimetric reagent used for measuring protein concentration.BCA is a Cu(I)-specific colorimetric reagent used for measuring protein concentration.2810 | BCA disodium salt...

K818 | BCA Protein Assay Kit - Reducing Agent Compatible DataSheet

K813 | BCA Protein Assay Kit II DataSheet

K819 | BCA Protein Assay Kit Test Tube - Reducing Agent Compatible DataSheet

K812 | BCA Protein Quantitation Kit DataSheet

5002 | BCA-1 (BLC/CXCL13) Antibody DataSheet

Human BCA-1 (B Cell-Attracting chemokine 1), also known as BLC or CXCL13, is a recently identified new CXC chemokines. Human BCA-1 is a highly effective attractant for human blood B lymphocytes, but...

A1060 | BCAT1 Monoclonal Antibody DataSheet

BCH001 is a specific PAPD5 (protein arginine deiminase 5) inhibitor; it restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells.BCH001...

6724 | BCHE Antibody (Center) DataSheet

BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level, downregulates known SMYD3 target genes transcription, and selectively affects...

K4240 | BCL-11B Human Elisa Kit DataSheet

3195 | Bcl-2 Antibody (Clone Bcl-2/100) DataSheet

3033 | Bcl-2 Antibody DataSheet

3033BP | Bcl-2 Blocking Peptide DataSheetAntibody Target: Bcl-2 Accession #: M13994Gene ID: 596Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

Cell-permeable. A small molecule pan–Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2–, Bcl-xl–, Bcl-w–,...

Cell-permeable. A potent and selective BCl-2 inhibitor that spares platelets while achieving potent antitumor activity.ABT-199 is a potent and selective BCl-2 inhibitor that spares platelets while...

3407 | Bcl-3 Antibody DataSheet

3407BP | Bcl-3 Blocking Peptide DataSheetAntibody Target: Bcl-3 Accession #: P20749Gene ID: 602Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

3408 | Anti-Bcl-6 Antibody DataSheet

3408BP | Bcl-6 Blocking Peptide DataSheetAntibody Target: Bcl-6Accession #: P41182Gene ID: 604Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

3695 | Bcl-B Antibody DataSheet

3695BP | Bcl-B Blocking Peptide DataSheetAntibody Target: Bcl-B Accession #: Q9HD36Gene ID: 10017Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3671 | Bcl-Rambo Antibody DataSheet

3671BP | Bcl-Rambo Blocking Peptide DataSheetAntibody Target: Bcl-Rambo Accession #: BC027307Gene ID: 94044Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in...

3312 | Bcl-xL Antibody DataSheet

3312BP | Bcl-xL Blocking Peptide DataSheetAntibody Target: Bcl-xL Accession #: L35049Gene ID: 561740Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

BCL-2 was the first anti-death gene discovered with far reaching implications in tumor biology. It regulates cell death by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis...

3577 | BCMA (TNFRSF17) Antibody DataSheet

BCMA, also named TNFRSF17, is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf--b...

6971 | BCRP (ABCG2) Antibody DataSheet

BD1047 is a potent and selective Sigma-1 Receptor antagonist. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- &...

The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Defensin-1 (BD-1) is an antimicrobial peptide having the resistance of...

5372 | BD-2 Antibody DataSheet

Recombinant human -defensin-2 (BD-2) is an antimicrobial peptide which belongs to the distinct family of -defensins. Recombinant human BD-2 is a 4.3 kDa protein containing 41 amino acid residues.4372...

Recombinant human -defensin-3 (BD-3) is an antimicrobial peptide, which belongs to the distinct family of -defenisns. Recombinant human BD-3 is a 5.1 kDa protein containing 45 amino acid residues...

Defensins are cationic peptides with a large spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha defensins are differentiated from the...

BDA-366 is a small-molecule Bcl2-BH4 domain antagonist, that binds BH4 with high affinity and selectivity. BDA-366-Bcl2 binding induces conformational change in Bcl2 that abrogates its antiapoptotic...

6725 | BDNF Antibody (CT) DataSheet

5004 | BDNF Antibody DataSheet

K4788 | BDNF human Elisa Kit DataSheet

Human Brain-Derived Neurotrophic Factor (BDGF) is a potent neurotrophic factor that supports the growth and survivability of nerve and glial cells. The active form of BDNF is a 27.0 kDa dimer, formed...

Beauvercin is an enniatin mycotoxin isolated from fungus Beauveria sp. It has shown cytotoxic properties against insect cells SF-9 and induces apoptosis with IC₅₀ value of 4.5 µM. It has shown to...

A potent, slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 µM. It is also a potent inhibitor of human arginase II with Ki values of 0.31 µM and 30 nM at pH...

3663BP | Beclin 1 Blocking Peptide DataSheetAntibody Target: Beclin 1 Accession #: O88597Gene ID: 56208Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

Bedaquiline is an anti-tuberculosis drug. Bedaquiline's unique and specific anti-mycobacterial activity derives from inhibition of the proton pump of mycobacterial ATP synthase, which is a critical...

Belizatinib (TSR-011) is a potent inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential...

Bempedoic acid is an ATP citrate lyase (ACL) inhibitor. ACL is an enzyme involved in fatty acid and cholesterol synthesis. Bempedoic acid is a convenient, oral, once-daily LDL-C lowering drug that...

Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat. It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity...

Bendamustine is a novel alkylating agent with a benzimidazole ring giving it purine analogue-like properties. Like other alkylating agents, bendamustine is thought to act by modifying and cross...

Benfotiamine is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine contains a thiazole ring. It helps in the prevention of diabetic complications such as,...

Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It blocks the conversion of L-DOPA to dopamine by AADC in the peripheral...

Benzo-Endonuclease is a genetically engineered endonuclease from Serratia marcescens gene that can digest all forms of DNA and RNA, including single stranded, double stranded, linear, circular and...

Golden Nuclease is a recombinant form of Serratia macescens extracellular endonuclease produced in Escherichia coli. Golden Nuclease is a homodimer with monomer molecular masses about 30 kDa. Two...

Bepidril hydrochloride is a non-selective calcium channel blocker and class IV antiarrhythmic agent. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; acts...

Berbemine is a naturally occurring alkaloid that displays several biological properties. Berbamine potently suppresses liver cancer cell proliferation and induces cancer cell death by targeting...

An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in acute lymphoblastic...

Bestatin is a competitive protease inhibitor that inhibits aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It displays no inhibition of aminopeptidase A, trypsin, chymotrypsin,...

A potent aminopeptidase inhibitor (Ki = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A4 hydrolase. Displays antitumor and immunostimulant properties.Bestatin is a potent...