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Clemizole is a H1-histamine receptor antagonist. Recently, Clemizole has been shown to inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.Clemizole is a H1-histamine receptor...

E4564 | Clenbuterol Elisa Kit DataSheet

Clindamycin is a broad spectrum antibiotic targeting primarily gram positive and gram negative bacteria such as Clostridium and Bacteroides species. It inhibits bacterial protein synthesis by binding...

An antiparasitic agent that forms stable complexes with copper and used for treatment of Alzheimer’s disease. Displays anticancer properties by inhibition of proteasome activity. It targets tumor...

3896 | CLOCK Antibody DataSheet

3896BP | CLOCK Blocking Peptide DataSheetAntibody Target: CLOCK Accession #: NP_031741Gene ID: 12753Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

A purine nucleoside antimetabolite that displays anticancer activity. Clofarabine displays potent inhibitory effects on both ribonucleotide reductase and DNA polymerase. Used in pediatrics to treat a...

Clofazimine is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It displays anti-inflammatory...

Clonidine is an antihypertensive agent that acts as an α2-adrenergic receptor agonist that decreases peripheral vascular resistance by centrally inhibiting sympathetic nerve activity. The...

Clorgyline is a potent, irreversible monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Ki's = 0.054 and 58 µM, respectively). Also acts as a Lysine-specific demethylase...

Cloxacillin sodium is a β-lactam antibiotic of penicillin subclass, which inhibits bacterial cell wall synthesis by targeting the proteoglycan synthesis. Cloxacillin has a narrow spectrum of action...

Clozapine N-oxide is a metabolite of clozapine that activates human muscarinic designer receptors (DREADDs) in vitro.Clozapine N-oxide is a metabolite of clozapine that activates human muscarinic...

CLP-290 is a novel KCC2 (K(+)-Cl(-) cotransporter isoform 2) modulator and prodrug of CLP-257, that is highly selective for KCC2 over related Cl- transporters.CLP-290 is a novel KCC2 (K(+)-Cl(-)...

K4260 | Clusterin Human Elisa Kit DataSheet

CM-272 is a potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM,...

CMA is a murine-selective STING agonist (Kd = 3.5 μM). It directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. CMA triggers type I IFN response in murine...

A potent and selective mutant ERLBD (Estrogen receptor ligand binding domain) ligand. Cell-permeable.CMP8 is a potent and selective mutant ERLBD (Estrogen receptor ligand binding domain) ligand.B2328...

MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a...

CMPD101 | B3392Description: CMPD101 is a potent, selective and cell-permeable GRK2/3 inhibitor (IC50 values are 32 and 54 nM for GRK3 and GRK2, respectively). CMPD101 displays selectivity for GRK2/3...

5017 | CNTF Antibody DataSheet

CNTF (Ciliary Neurotrophic Factor) is a potent neural factor that was originally characterized as a survivability factor for chick ciliary neurons in vitro. CNTF has also been shown to promote...

Ciliary neurotrophic factor, CNTFP1093 | CNTF, human recombinant DataSheetBiomolecule/Target :CNTFSynonyms: Ciliary neurotrophic factor, CNTFAlternates names: Ciliary neurotrophic factor,...

CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The...

CNX1351 is a potent and selective inhibitor of PI3Kα with IC50 value of 6.8 nMCNX1351 is a potent and selective inhibitor of PI3Kα with IC50 value of 6.8 nMB1673 | CNX-1351 DataSheetAlternate...

CO-1686 is an orally bioavailable, irreversible EGFR inhibitor, selectively targeting EGFRL858R/T790M mutant with a Ki value of 21 nM over Wt EGFR (Ki = 303 nM). Displays potent antineoplastic...

K505 | Cobalt Colorimetric Assay Kit DataSheet

Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes (Ki = 939 nM). Acts as a pharmacoenhancing or "boosting" agent for antiviral drugs used in the...

Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of...

3626BP | COCO/DAND5 Blocking Peptide DataSheetAntibody Target: COCO/DAND5Accession #: Q8N907Gene ID: 199699Appearance: Colourless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Cell-permeable. Coelenterazine is the luminescent substrate for Renilla luciferase and apoaequorin. When coelenterazine combines with luciferase, oxygen, and calcium ions, it produces...

Coelenterazine-h is the 2-deoxy derivative of the native Coelenterazine (Cat. No. 2536). Coelentarazine-h produces 10-fold higher light output than native coelentarazine with Renilla luciferase...

K367 | Coenzyme A CoA Colorimetric/Fluorometric Assay Kit DataSheet

A naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes. It is an endogenous cellular antioxidant and an essential component of the electron...

COG 133 is a fragment of Apolipoprotein E (APOE) that mimics the anti-inflammatory and neuroprotective effects of the intact apoE protein. It functions through the low-density lipoprotein...

Inhibitor of microtubules by specific binding to tubulin. Antimitotic tool used in cell division studies; Antibiotic; anti-inflammatory; therapeutic agent. Induce apoptosis in PC-12 cells and...

Colistin sulfate is a potent cationic peptide antibiotic of the polymyxin family that binds to lipids on the cell cytoplasmic membrane of Gram-negativeColistin sulfate is a potent cationic peptide...

E4617 | Collagen Type I COL1 Human Elisa Kit DataSheet

E4618 | Collagen Type I COL1 mouse Elisa Kit DataSheet

E4619 | Collagen Type I COL1 rat Elisa Kit DataSheet

Collagen is a major component of the extracellular matrix in vertebrates and it constitutes approximately 25% of total protein. It plays an important in cell adhesion and migration. Specific collagen...

Collagen-III human recombinant | 4797

K792 | Collagenase Activity Colorimetric Assay Kit DataSheet

K490 | Collagenase Collagen Degradation/Zymography Assay Kit Fluorometric DataSheet

E4646 | Collagenase I Human Elisa Kit DataSheet

E4647 | Collagenase I Rat Elisa Kit DataSheet

K833 | Collagenase Inhibitor Screening Kit Fluorometric DataSheet

Columbianadin (CBN) is a coumarin-type compound and one of the main bioactive constituents of the underground part of the herb, Angelica pubescens. Columbianadin has calcium-channel blocking...

A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial...

Complement C1q, Human Plasma (High Salt Buffer with Glycerol) | P1743Description: Complement subcomponent C1q is composed of three polypeptide chains (A, B, and C). C1q associates with C1r and C1s to...

Complement C1q, Human Plasma (High Salt Buffer) | P1742Description: Complement subcomponent C1q is composed of three polypeptide chains (A, B, and C). C1q associates with C1r and C1s to set up the...

Complement C3 (C3) is the most abundant component of the complement system, with levels in human plasma of ~1.2-1.5 mg/ml. It is central to the activation of both the classical and alternative...

Complement C4 (C4) plays a central role in both the classical and lectin pathways of complement activation, with levels in human plasma ~0.4 mg/ml. C4 circulates in human plasma as a heterotrimer of...

Complement Component 5 (C5) plays a central role in inflammatory and cellular death processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. The...

Complement subcomponent C1q is composed of three polypeptide chains (A, B, and C). C1q associates with C1r and C1s to set up the first component of the serum complement system. Activation of the...

A dihydroquinoxaline derivative that efficiently induces neuronal differentiation from mesenchymal stem cells (MSCs) with excellent efficiency. MSCs treated with Compound 1 display neural...

An adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon (Cat. Nos. 2565 & 2572). Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in...

Cell-permeable. A highly potent inhibitor of γ-secretase (IC₅₀ = 0.06 nM)Compound 34 is a highly potent inhibitor of γ-secretase (IC₅₀ = 0.06 nM)1898 | Compound 34 DataSheetAlternate Name/Synonyms:...

Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC₅₀ = 0.28 µM) that also targets mTOR (IC₅₀ = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in...

Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC₅₀ = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 µM),...

Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42...

Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase. It displays > 2000-fold selectivity over other H+-ATPases (IC₅₀ values are 9.2, > 20000, > 20000 and > 20000 nM for yeast...

Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid β-glucosidase, glucosylceramidase, GBA, or GBA1 (IC₅₀ = 9 μM). Inhibition of this lysosomal...

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors. Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors...

Congo Red amyloid fibril-binding dye; inhibits Fib-beta A neurotoxicity by inhibiting fibril formation or by binding to preformed fibrils. Congo red also inhibits the pancreatic islet cell toxicity...

Conophylline | B3383 Description: Conophylline is a naturally occurring plant-based vinca alkaloid that acts as a novel differentiation inducer for pancreatic β cells; can increase the numbers...

Control Magnetic Beads | M1302

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

K899 | Copper Detection Assay Kit Fluorometric DataSheet

Cordycepin is a known polyadenylation inhibitor with a large spectrum of biological activities, including anti-proliferative, pro-apoptotic and anti-inflammatory effects. Can be converted to...

A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4...

Streptavidin is a non-glycosylated protein originally isolated from bacterium Streptomyces avidinii. With a very high affinity for biotin, it is widely used to bridge biotinylated probes and enzymes...

K4222 | Corticosterone CORT Elisa Kit DataSheet

K7430 | Cortisol human/mouse/rat Elisa Kit DataSheet

K7434 | Cortisol Saliva Human Elisa Kit DataSheet

Coumarin boronic acid (CBA) is a fluorescent probe useful for the detection of peroxynitrite, hypochlorous acid, and hydrogen peroxide. It reacts directly and rapidly with peroxynitrite at a much...

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the...

Coumermycin A1 is a member of the aminocoumarin family of antibiotics that displays antibacterial activity against staphylococci and other gram-positive bacteria and some select gram-negative...

Coumestrol is naturally occurring phytoestrogen. It competitively binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells...

3361 | Cox-1 Antibody DataSheet

3361BP | Cox-1 Blocking Peptide DataSheetAntibody Target: Cox-1 Accession #: P22437 Gene ID: 19224Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3362R | Cox-2 Antibody DataSheet

3362BP | Cox-2 Blocking Peptide DataSheetAntibody Target: Cox-2Accession #: P35354Gene ID: 5743Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

3362RBP | Cox-2 Blocking Peptide DataSheetAntibody Target: Cox-2 Accession #: Gene ID: Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered saline...

K547 | COX-2 Inhibitor Screening Kit Fluorometric DataSheet

3687 | Cox-3 Antibody DataSheet

3687BP | Cox-3 Blocking Peptide DataSheetAntibody Target: Cox-3 Accession #: AAT0993Gene ID: 19224Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3638 | Cox-4 Antibody DataSheet

3638BP | Cox-4 Blocking Peptide DataSheetAntibody Target: Cox-4 Accession #: EAW95436Gene ID: 1327Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and...

CP-424,174 is a cytokine release inhibitory drug (CRID) that inhibits the post-translational processing and secretion of IL-1β in response to LPS and ATP in human monocytes. Also indirectly inhibits...

CP-466722 is a selective inhibitor of ATM kinase with IC50 value of 0.41 μM.CP-466722 is a selective inhibitor of ATM kinase with IC50 value of 0.41 μM.B1722 | CP-466722 DataSheetAlternate...

CP-544326 is a potent selective prostaglandin EP (2) receptor agonist which is the active acid metabolite of the prodrug PF-04217329 (Taprenepag isopropyl). CP-544326 was found to be a potent and...

CP-547,632 is a potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC₅₀ values of 11 and 9 nM, respectively. Displays anticancer...

CP-640186 hydrochloride is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀ values of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.CP-640186...

CP-640186 is a mixed ACC (Acetyl-CoA carboxylase) inhibitor (ACC-1 IC₅₀ = 53 nM; ACC-2 IC₅₀ = 61 nM) that lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis in vitro...

CP-673451 is a potent inhibitor of PDGFR with IC50 value of 10 nM and 1 nM for PDGFR-α and PDGFR-β, respectively.CP-673451 is a potent inhibitor of PDGFR with IC50 value of 10 nM and 1 nM for PDGFR-α...

CP-690550 citrate is the citrate salt of the potent JAK3 inhibitor CP-690550 (Cat. No.1622).CP-690550 citrate is the citrate salt of the potent JAK3 inhibitor CP-690550 (Cat. No.1622).9428 |...

Cell-permeable. A Janus Kinase 3 (JAK3) inhibitor. Displays greater antiproliferative and pro-apoptotic activity against murine multipotent factor-dependent cell Patersen-erythropoietin receptor...

CP-724714 is an inhibitor of erbB2 and EGFR kinasesCP-724714 is an inhibitor of erbB2 and EGFR kinasesB1333 | CP-724714 DataSheetAlternate Name/Synonyms:...

CP21R7, also known CP21, is a potent and selective GSK-3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to endothelial and smooth muscle...