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CPI-0610 is a potent, selective BET (bromodomain and extra terminal family of proteins) inhibitor and inhibits BRD4-BD1 with IC₅₀ of 39 nM. It potentially demonstrates anti-neoplastic activity by...

CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex.CPI-1189 prevents apoptosis and reduces glial fibrillary...

CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ =...

CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203...

CPI-444 is a potent adenosine A2A receptor antagonist. Upon oral administration, CPI-444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural...

CPI-455 hydrochloride is a potent and selective inhibitor of KDM5 demethylases. which reduces survival of drug-tolerant cancer cells. CPI-455 binds to the demethylase active site and selectively...

CPI-455 is a potent and selective KDM5A inhibitor (IC₅₀ ~10 nM). It inhibits KDM5A, KDM5B and KDM5C to similar extents but shows substantially weaker potency toward KDM4C and KDM7B (~200- and...

CPI-613 is a non-redox active lipoate derivative that acts as a selective inhibitor mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. In vitro, CPI-613...

CPTH2 (hydrochloride) is an inhibitor of Histone Acetyltransferase (HAT) activity of Gcn5. Gcn5 acetylates histones H2B and H3. CPTH2 inhibited HAT reaction in vitro and it decreased acetylation of...

CPUY192018 is a potent inhibitor of the Keap1-Nrf2 PPI protein-protein interaction. CPUY192018 displays cytoprotective effects by enhancing the Nrf2-ARE regulated antioxidant system and diminishes...

GRANAD-2 is a near-infrared Aβ plaque-specific fluorescent probe penetrating the blood brain barrier and label senile plaques specifically in vivo. Upon interacting with Aβ aggregates, CRANAD-2...

K635 | Creatine Colorimetric/Fluorometric Assay Kit DataSheet

Creatine Kinase, also known as CK, CPK, Creatine Kinase, Creatine Phosphokinase is an enzyme present in muscle, brain, and other tissues of vertebrates that catalyzes the reversible conversion of ADP...

K777 | Creatine Kinase CK Activity Colorimetric Assay Kit DataSheet

E4606 | Creatine Kinase MB CK-MB Human Elisa Kit DataSheet

E4607 | Creatine Kinase MB CK-MB Mouse Elisa Kit DataSheet

E4608 | Creatine Kinase MB CK-MB Rat Elisa Kit DataSheet

Creatine kinase is a cytoplasmic enzyme that reversibly catalyzes the transfer of a phosphate between ATP and various other molecules such as creatine phosphate. Creatine kinase MB is a heterodimer...

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family...

K625 | Creatinine Colorimetric/Fluorometric Assay Kit DataSheet

E4368 | Creatinine Human Elisa Kit DataSheet

E4369 | Creatinine Mouse Elisa Kit DataSheet

E4370 | Creatinine Rat Elisa Kit DataSheet

3360R | CREB Antibody DataSheet

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

3360RBP | CREB Blocking Peptide DataSheetAntibody Target: CREB Accession #: EDL98880Gene ID: 81646Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Crenigacestat (LY3039478), is a potent Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. LY3039478 potently inhibits mutant Notch receptor activity. In a xenograft tumor...

Crenolanib is a highly selective and potent FLT3 tyrosine kinase inhibitor (TKI) with activity against the internal tandem duplication (FLT3/ITD) mutants and the FLT3/D835 point mutants. Also...

5287 | CRIM1 Antibody (CT) DataSheet

K1250 | CRISPR Genomic Cleavage Detection Kit DataSheet

CRISPR sgRNA Synthesis Kit | K1251

A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at...

CRP rat Elisa Kit | K4764

Recombinant Human C-Reactive Protein produced in E. coli is a non-glycosylated polypeptide chain having a total molecular mass of 115kDa, corresponding to the pentamer structure of 23 kDa monomers...

Recombinant Human C-Reactive Protein produced in E. coli is a non-glycosylated polypeptide chain having a total molecular mass of 115kDa, corresponding to the pentamer structure of 23 kDa monomers...

3735 | CRSP1 Antibody DataSheet

Cell-permeable. A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC₅₀ of 18 nM. It acts by...

CRT0066101 is a potent inhibitor of protein kinase D (PKD). It inhibits all PKD isoforms (IC₅₀ values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). It displays selectivity for PKD...

A1064 | CRTH2 Polyclonal Antibody DataSheet

Cryptotanshinone is a natural product isolated from the roots of Salvia miltiorrhiza Bunge that displays a variety of biological activities. Displays antitumor activity by inhibition of STAT3 (IC₅₀ =...

K329 | Crystal Violet Cell Cytotoxicity Assay Kit DataSheet

3778 | CSE1 Antibody DataSheet

CSF1R-IN-1, is a potent CSF1R inhibitor (IC50 of 0.5 nM). CSF1R plays an important role in the recruitment and differentiation of tumor-associated macrophages (TAM).CSF1R-IN-1, is a potent CSF1R...

CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src oncoprotein through tyrosine phosphorylation of the c-src carboxy terminus (1). Cell...

CST6 is a member of the type 2 cystatin family. Some of the members are active cysteine protease inhibitors, while cystatin E/M moderate the inhibition of cathepsin B but is not active against...

CSTA, also known as Stefin A, is thiol protease inhibitors that form complexes with papain and the cathepsins B, H and L. The protein is one of the precursor proteins of the cornified cell envelope...

CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain...

5011 | CT-1 Antibody DataSheet

CT-2584 is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol will decreasing levels of...

CTACK is a chemotactic factor that attracts skin-associated memory T-lymphocytes. CTACK is involved in mediating homing of lymphocytes to cutaneous sites. CTACK Binds to CCR10. CTACK human...

CTACK is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+...

3796 | CTBP1 Antibody DataSheet

CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by mbilical vein and Vascular endothelial cells. CTGF...

CTGFL/WISP-2 is a 28.6 kDa protein that belongs to the CCN family of cysteine rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production,...

K4157 | CTLA4 /CD152 Human Elisa Kit DataSheet

A1083 | CTLA4 Polyclonal Antibody DataSheet

CTSB, also known as cathepsin B preproprotein, is a papain-family cysteine protease that is normally located in lysosomes. It has the ability to degrade several extracellular matrix components at...

CTx-0294885 is a broad-spectrum kinase inhibitor. CTx-0294885 displays inhibitory activity against a broad range of kinases in vitro. CTx-0294885 could be a potentially powerful new tool for analysis...

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC₅₀ values...

CUDC-305 is a potent inhibitor of Heat Shock Proteins, displaying high affinity for HSP90α/β (IC₅₀ = 100 nM) and HSP90 complex derived from cancer cells (IC₅₀ = 48.8 nM).CUDC-305 is a potent...

CUDC-907 potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes.CUDC-907 potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes.B1675 | CUDC-907 DataSheetAlternate...

CUR-61414 is a potent, cell-permeable , Hedgehog signaling pathway inhibitor (IC₅₀ = 100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks proliferation and induces apoptosis in...

Curcubitacin E is a potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to Jasplakinolide (Cat. No. 1689), binding to a different site. Binds specifically...

Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (COX) (IC₅₀ = 52 µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in...

Isolated from Penicillium sp. Displays cytotoxic, antifungal, anti-inflammatory, and antiprotozoal properties. Acts as a TGF-β signaling pathway inhibitor as well as inducible nitric oxide synthase...

offers low price and high-quality negative siRNA controls for human and mouse cells RNAi experiments. A negative control should be always included in a complete siRNA experiment. During the siRNA...

offers low price and high-quality positive siRNA controls for RNAi experiments. The siRNA positive control helps to ensure that the transfection, RNA extraction and detection methods are reliable...

offers low price and high quality Custom siRNA Oligos. All our siRNA oligos undergo vigorous process monitoring and strict quality control. Length and labeling are systematically controlled by PAGE...

CVT-10216 is a potent, selective, and reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT-10216 has been reported to...

CVT-313 is a potent and selective inhibitor of CDK2 (cyclin dependent kinase 2) arresting cell growth with IC₅₀ ranging from 1.25 to 20 µM. The Inhibition is competitive with respect to ATP (Ki = 95...

CW069 is an allosteric inhibitor of the microtubule motor protein HSET that induces multipolar mitoses only in cells containing supernumerary centrosomes.CW069 is an allosteric inhibitor of the...

CWHM-12 a potent small molecule inhibitor of αV integrins with IC₅₀s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8. It displays less potency on αvβ5 (IC₅₀ = 61 nM) and on inhibition on αIIbβ3/α2β1/α10β1...

A selective, ATP-competitive, Casein kinase -2 (CK2) inhibitor (Ki = 0.38 nM). Displays potent anti-tumor activity in several cancer cell lines.CX-4945 is a selective, ATP-competitive, Casein kinase...

CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC₅₀s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect...

CX-6258 is a potent pan-Pim kinases inhibitor (IC₅₀ values of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively). CX-6258 exhibits in vitro synergy with chemotherapeutics and robust in...

5537R | CX3CR1/RBS11 Antibody DataSheet

5537RBP | CX3CR1/RBS11 Blocking Peptide DataSheetAntibody Target: CX3CR1/RBS11 Accession #: NP_598218.1Gene ID: 171056Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5...

Human Chemokine (C-X-C motif) ligand 10(CXCL10),also known as Interferon gamma-inducible protein-10 (IP-10), is a non-ELR chemokine secreted by various cell types including monocytes, endothelial...

CXCL12/SDF-1 alpha human Elisa Kit | K4387

Human Chemokine (C-X-C motif) ligand 14(hCXCL14),also known as breast and kidney-expressed chemokine (BRAK), MIP-2 gamma, kidney-expressed chemokine (KEC), and B cell and monocyte-activating...

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune...

Chemokine (C-X-C motif) ligand 17, also known as CXCL17, is a small cytokine belonging to the CXC chemokine family. CXCL17 is a 119 amino acid secreted protein that plays a role in angiogenesis...

CXCL2 is a small cytokine belonging to the CXC chemokine family that is also known as Chemokine (C-X-C motif) ligand 2, and macrophage inflammatory protein 2-alpha (MIP2-alpha). CXCL2 is secreted by...

CXCL4 is a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is...

A1066 | CXCR-7 Polyclonal Antibody DataSheet

CXCR4 Antibody | 5224

5541BP | CXCR4 Blocking Peptide DataSheetAntibody Target: CXCR4 Accession #: O08565Gene ID: 60628Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

K4194 | CXCR4 Human Elisa Kit DataSheet

3419 | CXCR5 Antibody DataSheet

3419BP | CXCR5 Blocking Peptide DataSheetAntibody Target: CXCR5 Accession #: P32302Gene ID: 643Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

CY-09 is a potent and specific NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation.CY-09 is a potent and...

The recombinant CFP (Cyan Fluorescent Protein) is expressed and purified from transformed E. coli using a method that ensures high purity and maximal CFP fluorescence. Endotoxin has been removed, so...

Cyantraniliprole (HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.Cyantraniliprole...

CYC116 is a potent inhibitor of Aurora A and B with Ki value of 8 nM and 9.2 nM, respectively. It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases,...

Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and...

6932 | Cyclin E1 Antibody DataSheet

6933 | Cyclin F Antibody DataSheet

6934 | Cyclin G1 Antibody DataSheet

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the...

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the...