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A highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of...

Damnacanthal is a potent and inhibitor of p56lck tyrosine kinase and inhibits autophosphorylation with IC50 of 17 nM and phosphorylation of exogenous substrates with IC50 of 620 nM in cell free...

Danoprevir (R7227) is a potent and selective inhibitor of Hepatitis C Virus (HCV) NS3/4A protease, a chymotrypsin-like serine protease (IC₅₀ = 0.2 – 3.5 nM). Useful for the treatment of Hepatitis C...

Dantrolene sodium is an inhibitor of Ca²⁺ release from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Acts asa skeletal...

Danusertib (PHA-739358) is a potent pan-aurora kinase inhibitor with IC₅₀ values of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It modestly inhibits Abl, TrkA, c-RET and FGFR1, and weakly...

3261 | DAP1 Antibody DataSheet

5570R | DAP12 Antibody DataSheet

5570RBP | DAP12 Blocking Peptide DataSheetAntibody Target: DAP12 Accession #: AAD09438Gene ID: 22177Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Dapagliflozin is a selective SGLT (sodium-glucose cotransporter) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC₅₀ = 1.1 nM) over SGLT1 (Ki = 390 nM)...

DAPI is a fluorescent, cell-permeable DNA-binding dye preferentially binds to DNA rich in adenine and thymine. DAPI is useful in measuring nuclear DNA content using flow cytometry for sorting...

DAPPD is an antineuroinflammatory agent. DAPPD regulates microglial function, suppresses neuroinflammation, fosters cerebral Aβ clearance, and attenuates cognitive deficits in AD transgenic mouse...

Cell permeable. A potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and...

Daptomycin is a lipopeptide antibacterial antibiotic that exhibits rapid, concentration-dependent bactericidal activity against Gram-positive organisms in vitro. Daptomycin binds to bacterial...

Darapladib (SB-480848), is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor (IC₅₀ of 0.25 nM). It produces sustained inhibition of plasma Lp-PLA2 activity in humans receiving...

Darunavir is an HIV-1 protease inhibitor with an IC₅₀ of 3 nM and cytoxicity of 74.4 μM. It is also also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in...

DASA-58 is a selective activator of pyruvate kinase M2 (PKM2) (AC₅₀ = 38 nM). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated...

Dasatinib is a multi-kinase inhibitor with potent activity against BCR–ABL kinase (IC₅₀

Potent anti-cancer agent whose potential target site may be mitochondrial cytochrome c oxidase. Inhibits RNA and DNA synthesis. Also inhibits eukaryotic topoisomerase I & II. Induces DNA single...

3229 | Daxx Antibody DataSheet

3229BP | Daxx Blocking Peptide DataSheetAntibody Target: Daxx Accession #: Q9UER7Gene ID: 1616Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

DB07268 is a potent and selective JNK1 inhibitor with (IC₅₀ = 9 nM). DB07268 displays some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although DB07268...

Cell- permeable. A potent, selective, reversible, and ATP-competitive p97 inhibitor. DBeQ blocks both ubiquitin-dependent and autophagic protein clearance pathways and rapidly promotes executioner...

dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC₅₀ of 14 nM. dBET6 prompts a collapse of global elongation that phenocopies CDK9 inhibition. Displays...

DBZ is a potent γ-secretase inhibitor that blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC₅₀ = 1.7 nM).DBZ is a...

Dicarbonyl/L-xylulose reductase, also known as DCXR, is an enzyme responsible for the metabolism of xylulose, converting it into xylitol. DCXR was expressed at low levels and was localized...

Dimethylarginine Dimethylaminohydrolase (DDAH) metabolizes asymmetric dimethyl arginine (ADMA) to L-citrulline and dimethylamine, and NG-monomethyl arginine (MMA) to L-citrulline and monomethylamine...

DDP-38003 dihydrochloride is a potent, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM.DDP-38003 dihydrochloride is a potent, orally available...

DDR1-IN-1 is a potent and selective DDR1 inhibitorDDR1-IN-1 is a potent and selective DDR1 inhibitorB1331 | DDR1-IN-1 DataSheetAlternate Name/Synonyms:...

DDR2 is a member of a novel subclass of RTKs containing a distinct extracellular region encompassing a factor VIII-like domain (1) and is thought to be involved in the regulation of cell growth,...

Decernotinib (VX-509) is a potent and selective JAK3 inhibitor (Ki = 2 nM). it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a...

3645A | Decorin Antibody DataSheet

3645BP | Decorin Blocking Peptide DataSheetAntibody Target: DecorinAccession #: AAA52301.1Gene ID: 1634Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3891 | Dectin-1 Antibody DataSheet

3891BP | Dectin-1 Blocking Peptide DataSheetAntibody Target: Dectin-1 Accession #: EAW96155Gene ID: 64581Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

A synthetic substrate of cytochrome and mitochondrial permeability transition pore (MPTP) inhibitor.Decylubiquinone is a synthetic substrate of cytochrome and mitochondrial permeability transition...

3313 | DEDAF Antibody DataSheet

Alpha defensins are a family of mammalian defensin peptides. In general, defensins are small cysteine-rich cationic proteins found in both vertebrates and invertebrates. These mixed alpha defensins...

Deferasirox is an orally bioavailable tridentate iron chelator. It is selective for iron (Fe(III)) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III). Deferasirox decreases iron levels...

An iron chelator used for the treatment of acute iron intoxication and of chronic iron overload due to transfusion-dependent anemias. Has been shown to have anti-proliferative effects on vascular...

Deflazacort is a glucocorticoid that displays anti-inflammatory and immunosuppressive properties.Deflazacort is a glucocorticoid that displays anti-inflammatory and immunosuppressive properties.B2023...

A small-molecule inhibitor of the mammalian target of rapamycin (mTOR). Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and...

E4636 | Dehydroepiandrosterone DHEA Elisa Kit DataSheet

DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM.DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM.B1680 | DEL-22379 DataSheetAlternate Name/Synonyms: DEL-22379; DEL22379;...

Delafloxacin (ABT-492) is a fluoroquinolone antibiotic that displays high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and...

Delamanid is a new antituberculosis drug that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.Delamanid...

Delphinidin is a natural plant pigment. It serves as the precursor of certain anthocyanins. It is used as an anthocyanin standard.The pigment is found in grapes, cranberries, and some flowers. It is...

Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in...

E4670 | Dengue Virus IgG Elisa Kit DataSheet

E4671 | Dengue Virus IgM Elisa Kit DataSheet

E4500 | Deoxyribonuclease-1 DNase1 Human Elisa Kit DataSheet

Deoxyribonucleic acid (DNA) is a long double-helical molecule containing genetic information. DNA is a double-stranded (ds) molecule. Each strand is composed of an ordered combination of four...

DEPC is a non-specific inhibitor of Ribonucleases (RNases). To reduce degradation of RNA in experiments, water is treated with DEPC. A concentration of 0.1 % DEPC is used to reduce RNase...

K808 | Deproteinizing Sample Preparation Kit DataSheet

K823 | Deproteinizing Sample Preparation Kit II DataSheet

A fungal metabolite that acts as a potent HDAC inhibitor (IC50 = 4.7 µM for HDAC1). It reverts ras- and src-transformed NIH3T3 cells to a flat phenotype (1 µg/ml).Depudecin is a fungal metabolite...

Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and specific cyclooxygenase-2 (COX-2) inhibitor. Used in dogs to treat pain associated with osteoarthritis, or to...

Derazantinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. It binds to and potently inhibits the activity of FGFR...

Desipramine HCl is a tricyclic antidepressant that is a selective inhibitor of norepinephrine transporter with Ki values of 4 nM, 61 nM and 78.72 μM for Norepinephrine Transporter (NET), Serotonin...

K4190 | Desmin Human Elisa Kit DataSheet

Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It may be associated with the pathogenesis of...

Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. Destruxins show insecticidal, anti-viral, and phytotoxic properties. Destruxin A suppresses the Drosophila...

Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. It shows insecticidal and anti-cancer properties. It induces a concentration-dependent antiproliferative...

K485 | Deubiquitinase Activity Assay Kit Fluorometric DataSheet

An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC₅₀ = 5 nM). Enhances active cation...

Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid anti-inflammatory agent dexamethasone (Cat. No. 1042). Recently, it has been shown that in patients hospitalized with...

Dexmedetomidine is an imidazole derivate and an active d-isomer of medetomidine. Medetomidine is a racemate of the stereoisomers levomedetomidine and dexmedetomidine. Dexmedetomidine is a potent...

Dexpramipexole dihydrochloride is a neuroprotectant that may slow the progression of ALS by keeping the power on in deteriorating motor nerves. Dexpramipexole maintains mitochondrial function in...

Dexrazoxane | B3369Description: Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. Dexrazoxane could chelate iron to decrease the generation of ROS, thus preventing...

Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM)...

3049 | DFF40 Antibody DataSheet

3048 | DFF45 Antibody DataSheet

DFHBI is a cell-permeable non-fluorescent small molecule derived from the GFP chromophore. Upon binding to the “Spinach™” aptamer, DFHBI is converted to a highly fluorescent state that can be...

DFHBI-1T is a mimic of green fluorescent protein (GFP) fluorophore for imaging RNA in living cells. Fluorescence is activated by binding to Spinach2 or Broccoli aptamers. Displays peak excitation...

Mimic of red fluorescent protein (RFP) fluorophore for imaging RNA in living cells. Upon binding to the Corn™ aptamer, DFHO is converted to a highly fluorescent state that can be detected at the...

DG051 is a novel small-molecule inhibitor of leukotriene A4 hydrolase (LTA4H), the protein made by one of the genes in the leukotriene pathway that has been shown to link to risk of heart attack,...

3845BP | DGAT1 Blocking Peptide DataSheetAntibody Target: DGAT1 Accession #: EAW82128Gene ID: 8694Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate...

K7428 | DHEA-S human Elisa Kit DataSheet

’s DiaEasy™ dialyzer (1 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 10 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (12-14 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 10 ml. They can also be used for several other purposes as shown below. The...

’s DiaEasy™ dialyzer (3.5 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 10 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (6-8 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 10 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (10, 15 20 ml) floating racks are designed to support our DiaEasy™ Dialyzer tubes of 10, 15 and 20 ml volumes (Figure 1). Each of these racks can hold one tube. These floating...

’s DiaEasy™ dialyzer (1 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 15 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (12-14 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 15 ml. They can also be used for several other purposes as shown below. The...

’s DiaEasy™ dialyzer (3.5 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 15 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (6-8 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 15 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (1 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 20 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (12-14 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 20 ml. They can also be used for several other purposes as shown below. The...

’s DiaEasy™ dialyzer (3.5 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 20 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (6-8 kDa MWCO) can be used primarily for dialysis or buffer exchanges of sample volumes upto 20 ml. They can also be used for several other purposes as shown below. The DiaEasy™...

’s DiaEasy™ dialyzer (250 µl) floating racks are designed to support our DiaEasy™ Dialyzer tubes of 250 µl volume. Each of these racks can hold upto 4 tubes.1020 | DiaEasy™ Dialyzer (250 µl) Floating...

’s DiaEasy™ dialyzer (12-14 kDa MWCO) can combines two modes of action, 1) dialysis or buffer exchange at sample volumes between 10-250 µl and 2) electro-elution of macromolecules from polyacrylamide...

’s DiaEasy™ dialyzer (25 kDa MWCO) can combines two modes of action, 1) dialysis or buffer exchange at sample volumes between 10-250 µl and 2) electro-elution of macromolecules from polyacrylamide or...

’s DiaEasy™ dialyzer (6-8 kDa MWCO) can combines two modes of action, 1) dialysis or buffer exchange at sample volumes between 10-250 µl and 2) electro-elution of macromolecules from polyacrylamide...

’s DiaEasy™ dialyzer (250 µl) supporting trays are designed to support our DiaEasy™ Dialyzer tubes of 250 µl volume during the process of electro-elution of any protein, protein-protein, or protein-...

’s DiaEasy™ dialyzer (3 ml) floating racks are designed to support our DiaEasy™ Dialyzer tubes of 3 ml volume. Each of these racks can hold upto 4 tubes.1016 | DiaEasy™ Dialyzer (3 ml) Floating racks...

’s DiaEasy™ dialyzer (12-14 kDa MWCO) can combines two modes of action, 1) dialysis or buffer exchange at sample volumes between 0.1-3 ml and 2) electro-elution of macromolecules from polyacrylamide...

’s DiaEasy™ dialyzer (25 kDa MWCO) can combines two modes of action, 1) dialysis or buffer exchange at sample volumes between 0.1-3 ml and 2) electro-elution of macromolecules from polyacrylamide or...

’s DiaEasy™ dialyzer (3.5 kDa MWCO) can combines two modes of action, 1) dialysis or buffer exchange at sample volumes between 0.1-3 ml and 2) electro-elution of macromolecules from polyacrylamide or...