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Cell-permeable. A pan-specific ubiquitin isopeptidase inhibitor (IC₅₀ = 45, 37 and 9.8 µM for USP2, USP7 and SENP2 respectively). NSC-632839 does not affect proteasome proteolytic activity. Induces...

A cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Treatment of cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated...

DuP-697 is a potent and selective inhibitor of cyclooxygenase-2 (IC₅₀ values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo...

DuSP10 (Dual specificity protein phosphatase 10) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases (DuSPs) inactivate their target kinases by dephosphorylating...

Dual specificity phosphatase 18, also known as DuSP18, is a member of the dual-specificity phosphatase (DSP) family, which catalyzes dephosphorylation of phosphotyrosine and phosphothreonine residues...

DuSP21 (Dual specificity protein phosphatase 21) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases (DuSPs) inactivate their target kinases by dephosphorylating...

DuSP23, also known as low molecular mass dual specificity phosphatase 3(LDP-3), belongs to the protein-tyrosine phosphatase family. This protein is a protein phosphatase that mediates...

Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural...

3684R | Dvl3 Antibody DataSheet

3684RBP | Dvl3 Blocking Peptide DataSheetAntibody Target: Dvl3 Accession #: EDK97569Gene ID: 13544Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

DY131 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. It displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μMDY131 is a selective agonist at...

DYKDDDDK Tag Antibody Clone IE6 | 3022

3989BP | DYKDDDDK-Tag Blocking Peptide DataSheetAntibody Target: DYKDDDDK-Tag Accession #: N/AGene ID: N/AAppearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

E4700 | DYKDDDDK-Tag Protein Elisa Kit DataSheet

Cell-permeable. A reversible, noncompetitive inhibitor of dynamin that interferes in vitro with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small...

3586R | Dystrophin Antibody DataSheet

Antibody Target: Dystrophin Accession #: NP_004002.2Gene ID: 1756Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2,...

E-64 is an irreversible, cell-permeable, potent, and highly selective cysteine protease inhibitor. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors,...

E-64d is a synthetic analog of E-64 which is a membrane permeable inhibitor of lysosomal and cytosolic cysteine proteases. It inhibits cathepsins B and L in intact lysosomes and cells. It (20-200...

E-7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 (IC₅₀ = 13.5 nM). It possesses significant antitumor growth activity in multiple preclinical tumor models through...

K4189 | E-Cadherin Human Elisa Kit DataSheet

3631 | E-Selectin Antibody DataSheet

3631BP | E-Selectin Blocking Peptide DataSheetAntibody Target: E-Selectin Accession #: P16581Gene ID: 6401Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

E. coli DNA Ligase is an NAD+ dependent enzyme that catalyzes the formation of a phosphodiester bond between cohesive 3′-hydroxyl and 5′-phosphoryl termini of double-stranded DNA (dsDNA)M1217 | E...

E. coli DNA Polymerase I is a DNA-dependent polymerase with intrinsic 3’→5’ and 5’→3’ exonuclease activities. Nick translation is facilitated by this enzyme due to the removal of nucleotides ahead of...

E. Coli Exonuclease I catalyzes the removal of nucleotides from single-stranded DNA in the 3’→5’ direction, releasing deoxyribonucleoside 5'-monophosphates and leaving 5'-terminal dinucleotides...

E. coli Exonuclease III digests duplex DNA in the 3´→5´ direction from nicked DNA, blunt end DNA, 3´-recessed ends, or 3´-overhangs of less than four bases, and yields nucleoside 5´-phosphatesM1223 |...

Carbonic anhydrase (CA) is an enzyme that catalyses rapid conversion of carbon dioxide to bicarbonate and protons (CO2 + H2O HCO3 + H+). Most carbonic anhydrases contain a zinc ion in their active...

D-gluconate kinase, thermosensitive, also known as idnk, D-gluconate kinase, thermosensitive, also known as idnk, is a 187 amino acid protein that belongs to the gluconokinase gntK/gntV family and...

SlyD is a putative folding helper protein from the Escherichia coli cytosol, which consists of an N-terminal prolyl isomerase domain of the FKBP type and a presumably unstructured C-terminal tail. It...

Thioredoxin (Trx) is a low molecular weight redox protein. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. It is involved in the first unique...

Thioredoxin reductases are the only known enzymes to reduce thioredoxin. Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. Both...

Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of the pentose phosphate pathway, a metabolic pathway that supplies reducing energy to cells by maintaining the level of NADPH. G6PD...

E6005 (RVT 501), a selective phosphodiesterase 4 (PDE4) inhibitor, developed for the treatment of atopic dermatitis.E6005 (RVT 501), a selective phosphodiesterase 4 (PDE4) inhibitor, developed for...

3744 | E6AP Antibody DataSheet

E7820 is a small molecule sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule...

EAI-045 is a potent and selective EGFR inhibitor. EAI-045 targets selected drug-resistant EGFR mutants but spares the wild-type receptor. EAI-045 inhibits L858R/T790M-mutant EGFR with low-nanomolar...

Easy One Step RT Kit | M1162

K1351 | EasyRNA™ Bacterial RNA Kit DataSheet

K1373 | EasyRNA™ Blood RNA Mini Kit DataSheet

K1337 | EasyRNA™ Cell/Tissue RNA Mini Kit DataSheet

K1419 | EasyRNA™ Fungal RNA Kit DataSheet

K1374 | EasyRNA™ Plant RNA Mini Kit DataSheet

One Step RT PCR KitM1163 | Easy™ One Step RT Kit-Dye DataSheetSort Name: Easy™ One Step RT Kit-DyeLabel Name: Easy™ One Step RT Kit-DyeTaglines: One Step RT PCR KitProduct Highlights: One Step RT PCR...

The encoded EBA G9 protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. It serves as a prognostic marker for cancers such as adenocarcinomas of the lung...

EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC₅₀ of 4 nM for EZH2(A667G). EBI-2511 displays excellent in vivo efficacy in Pfeiffer tumor Xenograft models in mouse and could...

An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione...

E4687 | EBV-VCA IgA Elisa Kit DataSheet

E4688 | EBV-VCA IgG Elisa Kit DataSheet

E4689 | EBV-VCA IgM Elisa Kit DataSheet

Enoyl Coenzyme A hydratase, short chain 1 mitochondrial, also known as ECHS1, is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Expressed in muscle, liver...

K820 | ECL Western Blotting Substrate Kit DataSheet

3843 | ECM Antibody DataSheet

3843BP | ECM Blocking Peptide DataSheetAntibody Target: ECM Accession #: AAD13396Gene ID: 13601Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

ECOSURF™ EH-9, MegaPure™ Detergent, 10% Solution | B3362Description: ECOSURF™ EH-9 is a biodegradable, next-generation nonionic surfactant with low odor.Alternate Name/Synonyms: Alcohol ethoxylate...

Edaravone is a low-molecular-weight antioxidant drug targeting peroxyl radicals among many types of reactive oxygen species. Most notably, it reduces damage due to ischemia-reperfusion injury in...

3904BP | EDEM1 Blocking Peptide DataSheetAntibody Target: EDEM1Accession #: Q2925U4Gene ID: 192193Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

6633BP | EDEM2 Blocking Peptide DataSheetAntibody Target: EDEM2Accession #: Q9BV94Gene ID: 55741Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3614BP | EDEM3 Blocking Peptide DataSheetAntibody Target: EDEM3Accession #: Q9BZQ6Gene ID: 80267Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

A1056 | EDG4 Antibody (NT) DataSheet

Edicotinib is a potent and selective inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) (IC₅₀ = 3.2 nM) with potential antineoplastic activity. Displays weak affinity for KIT and FLT3...

Edonerpic is a neural plasticity enhancer. It enhances motor function recovery from internal capsule hemorrhage in nonhuman primates. Edonerpic protects against MPTP-induced neurotoxicity by blocking...

Edoxaban tosylate is an antithrombotic agent that directly inhibits Factor Xa (FXa), a key serine protease that converts prothrombin to thrombin in the coagulation cascade.Edoxaban tosylate is an...

A 0.5 M solution of ethylenediaminetetraacetic acid disodium (EDTA) in water (pH 8.0).2103 | EDTA Solution DataSheetSort Name: EDTA SolutionLabel Name: N/ATaglines: 0.5 M EDTA solutionProduct...

Polycomb protein Embryonic Ectoderm Development (EED) is a WD repeat containing member of the Polycomb-group (PcG) family. The EED protein mediates repression of gene activity through histone...

EED-226 is a potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC₅₀ = 23.4 nM). EED-226 binds to the H3K27me3 binding pocket of EED (Embryonic Ectoderm Development) to...

eEF1 promotes the GTP-dependent binding of elongator aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1)...

eEF2 promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.P1316 | eEF2 Rabbit Reticulocytes DataSheetBiomolecule/Target: eEF2Synonyms:...

Eeyarestatin I is an inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the...

Eflornithine (Difluoromethylornithine) is a fluorinated ornithine analog that acts as an irreversible inhibitor of ornithine decarboxylase (ODC). It displays antiangiogenic activity, inhibits...

3489 | EG-VEGF Antibody DataSheet

Human EG-VEGF (Endocrine-gland-derived Vascular endothelial growth factor) induces proliferation, migration and fenestration in capillary endothelial cells derived from endocrine glands. Recombinant...

5022 | EGF Antibody DataSheet

K4022 | EGF human Elisa Kit DataSheet

K4023 | EGF mouse Elisa Kit DataSheet

K4024 | EGF rat Elisa Kit DataSheet

EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally...

EGF (Epidermal Growth Factor) is polypeptide growth factor that stimulates the proliferation of a wide range of epidermal and epithelial cells. Recombinant murine EGF is a 6.0 kDa protein containing...

Epidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal...

3782 | EGFR Antibody DataSheet

K4168 | EGFR/ErbB1 Human Elisa Kit DataSheet

6151 | EGLN1 Antibody DataSheet

6678 | EHHADH Antibody DataSheet

6678BP | EHHADH Blocking Peptide DataSheetAntibody Target: EHHADHAccession #: Q08426Gene ID: 1962Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

6837 | EHMT1 polyclonal antibody DataSheet

6152 | EHMT2 Antibody DataSheet

A selective inhibitor of the cGMP-specific phosphodiesterase (PDE2) (IC₅₀s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet)...

EHop-016 is an analog of NSC-23766 (Cat. No. 1941) that acts as a potent inhibitor of Rac GTPase (IC₅₀ = 1.1 µM for Rac1). The IC₅₀ of 1.1 μM for Rac inhibition by EHop-016 is ∼100-fold lower than...

EI1 is a potent EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively). It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold...

EIDD-2801 is an orally bioavailable prodrug of the potent ribonucleoside analog EIDD-1931. EIDD-2801 displays broad spectrum antiviral activity against influenza virus and multiple coronaviruses,...

eEF2 promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.P1317 | eIF2 Rabbit Reticulocytes DataSheetBiomolecule/Target: eIF2Synonyms:...

eIF3 is the largest translation factor and consists of 12 subunits. Complex organization of eIF3 explains its role in almost all steps of translation initiation, including ribosomal subunit...

Elacridar is a potent P-glycoprotein (P-gp/ABCG1) and breast cancer resistance protein (BCRP) inhibitor . GF120918 increases the bioavailability of cytotoxic anti-tumor drugs, and also leads to...

Elagolix sodium is a human GnRH (Gonadotropin-Releasing Hormone) receptor antagonist with an IC₅₀ and Ki of 0.25 and 3.7 nM, respectively. Elagolix alters the level of pituitary GnRH suppression and,...

A potent, irreversible inhibitor of human neutrophil elastase (HNE). The structure of the enzyme-inhibitor complex reveals crosslinking of the catalytic residues His-57 and Ser-195 by the peptidyl...

A potent, irreversible inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).Elastase Inhibitor, SPCK is a potent, irreversible inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).1921 |...

A useful fluorogenic substrate for neutrophil elastase. Cleavage of this peptide by the enzyme generates a strongly fluorescent AFC that is monitored fluorometrically. λex: 380 nm; λem: 500 nm...

Elastase, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum...

Elastase, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, pro-elastase, and activated in the...

Elastatinal is a potent, selective, and an irreversible elastase inhibitor (Ki = 240 nM). Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes. Displays antiviral...