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HMW kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a cofactor in the activation of factor XI, XII, and prekallikrein...

LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW...

KIRA-6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC₅₀ = 0.6 µM) and blocks oligomerization. It has been shown to...

Kirromycin belongs to elfermycin group of antibiotics that inhibits as a protein biosynthesis inhibitor. It is shown to interfere with the peptide transfer reaction by acting on elongation factor Tu...

3590 | KiSS-1 Antibody DataSheet

3590BP | KiSS-1 Blocking Peptide DataSheetAntibody Target: KiSS-1 Accession #: NP_839991Gene ID: 280287Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

KKL-35 is a potent trans-translation inhibitor that displays broad-spectrum antibiotic activity. KKL-35 inhibits trans-translation, and subsequent cell growth in a broad spectrum of bacterial strains...

KL001 is a cryptochrome protein (CRY) stabilizer. It blocks ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. Represses glucagon-induced hepatic...

3089 | KLF4 antibody DataSheet

3089BP | KLF4 Blocking Peptide DataSheetAntibody Target: KLF4Accession #: Q923V7 Gene ID: 114505Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

5300 | KLF4 mAntibody (4G6E11) DataSheet

A1053 | KLH Polyclonal Antibody DataSheet

Prostate-specific antigen, also known as Gamma-seminoprotein, Kallikrein-3, kallikrein-related peptidase 3, SemenoGelase, KLK3 and PSA, is a secreted protein which belongs to thepeptidase S1 family...

Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is...

Killer cell lectin-like receptor subfamily B member 1, also known as KLRB1, plays an inhibitory role on natural killer (NK) cells cytotoxicity. Natural killer (NK) cells are lymphocytes that mediate...

NKG2-C type II integral membrane protein, also known as KLRC2, plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The group,...

KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation...

KLRG1 belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes that can...

KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface...

KM-11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It increases the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5...

Cell-permeable. KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect...

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).KN-92 is an...

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).KN-92 is an...

Cell-permeable. KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or...

Cell-permeable. A Potent and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaM kinase II) (IC₅₀ = 0.37 μM).KN-93, Water-Soluble is a potent and selective inhibitor of...

Kobe0065 is a small-molecule inhibitor of Ras with Ki value of 46 μM for the binding of H-Ras.GTP to c-Raf-1Kobe0065 is a small-molecule inhibitor of Ras with Ki value of 46 μM for the binding of...

Kobe2602 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki...

KR-33493 is a potent FAS-associated factor 1 (FAF1) inhibitor with potential applications in treatment of Parkinson’s Disease.KR-33493 is a potent FAS-associated factor 1 (FAF1) inhibitor with...

KRIBB11 is a Heat shock factor (HSF) inhibitor (IC₅₀ = 1.2 μM). KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of...

KRN-633 is a cell-permeable, reversible, and ATP-competitive inhibitor of VEGFR kinase activity (IC₅₀ values of 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively). At higher...

KS-176 is a potent and specific inhibitor of Breast Cancer Resistance Protein (BCRP) / ATP-binding cassette sub-family G member 2 (ABCG2). Displays no inhibitory activity against P-gp or MRP1.KS-176...

A derivative of the protein kinase inhibitor K252a (Cat. No. 2013). Acts as a potent, selective, ATP-competitive inhibitor of protein kinase A (PKA) (Ki = 60 nM). Has no effect on PKC, PKG and MLCK...

Cell-permeable. KT5823 is a derivative of K-252a (Cat. No. 2013) that acts as a selective inhibitor of Protein kinase G (PKG) (Ki = 0.234 µM). Inhibits other kinases at much higher concentrations...

KU-0060648 | B1115

Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases...

KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. It displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase...

KW-2478 is a potent non-ansamycin heat-shock protein 90 (HspP90) inhibitor (IC₅₀ = 3.8 nM). Displays potent anticancer activity.KW-2478 is a potent non-ansamycin heat-shock protein 90 (HspP90)...

KX-392 is a potent oral non-ATP competitive inhibitor of Src kinase and tubulin polymerization. KX2-391 shows steep dose-response curves against Huh7 (GI₅₀ = 9 nM), PLC/PRF/5 (GI₅₀ = 13 nM), Hep3B...

Promotes cardiac differentiation of human pluripotent stem cells (hPSCs) and human embryonic stem cells (hESCs) into cardiomyocytes. KY02111 promotes differentiation by inhibiting WNT signaling in...

E4629 | Kynurenine KYN Elisa Kit DataSheet

Norepinephrine is a catecholamine hormone that functions as an adrenergic neurotransmitter. It increases heart rate, blood pressure, alertness and triggers the release of glucose. The levels of...

L-189 is a DNA ligase I, III and IV inhibitor (IC₅₀ values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki= 5 μM for DNA ligase I). L-189 inhibits base excision repair (BER) and...

L-67 is a competitive human DNA ligase inhibitor, that inhibits DNA ligases I and III with IC₅₀ values of 10 μM and 10 μM. L-67 significantly increases the cytotoxicity of DNA damaging agents. L-67...

L-755,507 is a partial agonist of β3-adrenergic receptors (EC₅₀ = 0.43 nM). It displays >440-fold selectivity for β3- over β1- and β2-adrenoceptors (EC₅₀s = 580 and >10,000 nM, respectively)...

L-778123 hydrochloride is a potent inhibitor of FPTase and GGPTase-I with an IC₅₀ of 2 nM and 98 nM, respectively, in enzyme inhibition determination.L-778123 hydrochloride is a potent inhibitor of...

L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.L-779450 is a potent, ATP-competitive...

L-838, 417 is a subtype-selective GABAA receptor partial agonist. It selectively binds to α1, α2, α3 and α5 subunits (Kivalues are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy...

K639 | L-Amino Acid Quantitation Colorimetric/Fluorometric Kit DataSheet

K749 | L-Arginine Assay Kit Colorimetric DataSheet

Also known as Vitamin C, Ascorbic acid functions as a powerful antioxidant, particularly in regards to reactive oxygen species (ROS). It functions as an enzymatic cofactor for multiple enzymes,...

L-Asparaginase is an enzyme that depletes L-Asparagine "an important nutrient for cancer cells" resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E.coli,...

L-Buthionine-(S,R)-Sulfoximine is a potent, fast acting, irreversible inhibitor of gamma-glutamylcysteine synthetase the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative...

K642 | L-Carnitine Colorimetric/Fluorometric Assay Kit DataSheet

L-DON is a glutamine antagonist produced naturally by Streptomyces; it inhibits several glutamine-dependent enzyme pathways as well as acts as an inhibitor of the mitochondrial enzyme, glutaminase...

L-JNK Peptide Inhibitor competitively blocks the interaction between JNK and c-Jun, thereby inhibiting the signaling events downstream of JNK, like c-Jun, ATF-2 and ELK1 phosphorylation. To convert...

E4571 | L-lactate dehydrogenase A chain LDHA Human Elisa Kit DataSheet

LodA is a novel enzyme (EC 1.4.3.20) that catalyzes the chemical reaction:L-lysine + O2 + H2O↔ 6-amino-2-oxohexanoate + NH3 + H2O2. It has antibacterial activity against a wide spectrum of...

Methionine gamma-lyase (EC 4.4.1.11) from Pseudomonas putida is a PLP-dependent enzyme which plays a central role in sulfur amino acid metabolism. METase catalyzes the , -elimination of methionine to...

A1015 | L-Methionine y-Lase Polyclonal Antibody DataSheet

A pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for...

A competitive, irreversible and non-selective inhibitor of all three NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively...

L-Propargylglycine (PAG) is an inhibitor of cystathionine γ-lyase (CSE). Cystathionine γ-lyase catalyzes H2S synthesis and is a potential target for modulating H2S levels under pathophysiological...

3632 | L-Selectin/CD62L Antibody DataSheet

3632BP | L-Selectin/CD62L Blocking Peptide DataSheetAntibody Target: L-Selectin/CD62L Accession #: P14151Gene ID: 6402Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2...

A potent antioxidant that enhances the activity of glutathione peroxidase in endothelial cells. It induces p53-mediated cell cycle arrest and apoptosis in human colon cancer cells.L-Selenomethionine...

L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder...

L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is...

6857 | L3MBTL1 polyclonal antibody DataSheet

offers miRNA negative control for miRNA experiments. The miRNA Negative Control has no homology to any known microRNA or mRNA sequences and thus ensures the specificity of the experiment.M1264 |...

’s miRNA Inhibitor Neg Control is designed to use as a negative control in miRNA inhibitor experiments. It is a random sequence that has been tested and validated to have no effects on miRNA function...

offers low price and high-quality Labeled negative siRNA controls for human and mouse cells RNAi experiments. The labeled the negative control can be easily observed under fluorescent microscope to...

offers low price and high quality Pre-designedFluorescent Dye Labeled siRNA Oligo Set for the customers who intend to ensure the inhibition efficiency in siRNA experiments. The customer needs to...

offers low price and high quality Pre-designedFluorescent Dye Labeled siRNA Oligo Set for the customers who intend to ensure the inhibition efficiency in siRNA experiments. The customer needs to...

offers miRNA mimics, which are RNA oligonucleotides designed to mimic endogenous mature microRNAs (miRNAs) for use in miRNA function research. Each microRNA mimics includes one strand that is...

Labetalol is a competitive antagonist of β- and α-adrenergic receptors. It is used as an antihypertensive agent. It also shows antioxidant acitivity with an IC₅₀ of 16.5 mg/L in...

Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby...

Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby...

7006 | Lactalbumin Antibody DataSheet

-Lactalbumin is an important whey protein in cow's milk, and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the...

K627 | Lactate Colorimetric Assay Kit II DataSheet

K607 | Lactate Colorimetric/Fluorometric Assay Kit DataSheet

Lactate Dehydrogenase Activity Colorimetric Assay Kit | K726

E4341 | Lactate human Elisa Kit DataSheet

Lactoferrin is a glycoprotein present in exocrine secretions and in the secondary granules of polymorphonuclear neutrophils. It is the iron binding protein in milk. Lactoferrin is known to regulate...

Lactoferrin is a glycoprotein present in exocrine secretions and in the secondary granules of polymorphonuclear neutrophils. Lactoferrin is known to regulate intestinal iron absorption, and to...

K624 | Lactose Colorimetric/Fluorometric Assay Kit DataSheet

LAG-1 is CC chemokine receptor (beta chemokine receptors) that signals through the CCR5 receptor. LAG-1 is identical to MIP-1 (ACT II isotype) except for two amino acid substitutions; arginine for...

E4552 | LAG3 Human Elisa Kit DataSheet

3267 | Lamin A Antibody DataSheet

3267BP | Lamin A Blocking Peptide DataSheetAntibody Target: Lamin A Accession #: BC033088Gene ID: 4000Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3807 | Lamin B1 Antibody DataSheet

3807BP | Lamin B1 Blocking Peptide DataSheetAntibody Target: Lamin B1 Accession #: P14733Gene ID: 16906Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC₅₀ values of 10, 62, and 96 μM, respectively. Also blocks heterologously expressed...

5077 | LAMP-1 Antibody (Center) DataSheet

5078 | LAMP-2 Antibody (CT) DataSheet

3900BP | LAMP2 Blocking Peptide DataSheetAntibody Target: LAMP2 Accession #: BAC33265Gene ID: 16784Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Lanatoside C is a cardiac glycoside, used in the treatment of congestive heart failure and cardiac arrhythmia. Lanatoside C suppresses colorectal cancer cell growth by inducing mitochondrial...

Lanifibranor is a novel pan-PPAR (peroxisome proliferator-activated receptors) agonist.Lanifibranor is a novel pan-PPAR (peroxisome proliferator-activated receptors) agonist.B1996 | Lanifibranor...

Lanraplenib is a potent and selective second generation SYK inhibitor (IC50=9.5 nM). Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding...

Lanreotide is a synthetic polypeptide analogue of somatostatin that resembles the native hormone in its ability to suppress levels and activity of growth hormone, insulin, glucagon and many other...