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Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase. It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM,...

Lapatinib is a potent inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM), ErbB-4 kinase (Ki = 347 nM). Lapatinib can restore tamoxifen sensitivity in tamoxifen-resistant, ER-positive...

A free base form of Lapatinib Ditosylate (Cat. No. 1624-25, 100).Lapatinib, Free base is a free base form of Lapatinib Ditosylate (Cat. No. 1624-25, 100).2138 | Lapatinib, Free base...

LAQ824 (Dacinostat) is a potent HDAC inhibitor (IC₅₀ = 32 nM) that displays significant activity against multiple myeloma.LAQ824 (Dacinostat) is a potent HDAC inhibitor (IC₅₀ = 32 nM) that displays...

A potent immunomodulator. Also displays anti-inflammatory properties.Laquinimod is a potent immunomodulator. Also displays anti-inflammatory properties.2332 | Laquinimod DataSheetAlternate...

Laq™ DNA Polymerase is the thermostable DNA polymerase of Pyroccus glycovorans from the East Pacific Rise. It amplifies Long DNA products with high Accurate and Quick polymerization rate in DNA...

Lasalocid A Sodium | B1587

Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan...

Lasofoxifene is a unique, non-steroidal selective estrogen receptor modulator (SERM). It selectively binds to human ERα with an IC₅₀ value of 1.5 nM and inhibits bone loss in ovariectomized rats. Has...

3830 | LASS5 Antibody DataSheet

3830BP | LASS5 Blocking Peptide DataSheetAntibody Target: LASS5Accession #: AAH33558.1Gene ID: 91012Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) Lass5 peptide in...

Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug of the free acid, that acts as a potent agonist of the FP receptor in...

A cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes...

A cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes...

A potent, third-generation, selective inhibitor of certain forms of the epidermal growth factor receptor (EGFR) with activating mutations, with potential antineoplastic activity. Upon administration,...

’s Lennox LB Broth is used in molecular genetic studies. It is a nutritionally rich media for the growth and maintenance of cultures of recombinant strain of E. coli. The inclusion of casein peptone...

’s LB Miller Broth is used in molecular genetic studies, as well as maintaining and propagating E. coli in molecular and microbiology procedures. The inclusion of casein peptone and yeast extract...

LB-100 is a potent protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. LB-100 is a potent protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.85...

Natural LBP is a 58 kDa glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNF). It acts as opsonin...

Natural LBP is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNF). It acts as opsonin...

3233 | LC3 (APG8) Antibody (Clone 166AT1234) DataSheet

3235 | LC3 (APG8A) (Isoform A specific) Antibody DataSheet

6948 | LC3 (APG8A) (NT) Antibody DataSheet

6946 | LC3 (APG8B) (NT) Antibody DataSheet

6950 | LC3 (APG8C) Antibody DataSheet

6947 | LC3A (Cleaved) Antibody DataSheet

6949 | LC3B (Cleaved) Antibody DataSheet

3498 | Lck Antibody DataSheet

3498BP | Lck Blocking Peptide DataSheetAntibody Target: LckAccession #: P06239Gene ID: 3932Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

Lck (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the...

A SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP)A SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP)B1601 | LCL161 DataSheetAlternate...

LDE-225 diphosphate is the phosphate analog of Smoothened (Smo) antagonist LDE-225 (Cat. No. 2892).LDE-225 diphosphate is the phosphate analog of Smoothened (Smo) antagonist LDE-225 (Cat. No. 2892)...

LDE225 is a potent and selective antagonist of Smoothened (Smo) with IC₅₀ values of 2.5 nM and 1.3 nM for human and mouse Hedgehog, respectively. LDE-225 induces dose-related inhibition of Hh and...

3842 | LDH Antibody DataSheet

K311 | LDH-Cytotoxicity Colorimetric Assay Kit DataSheet

K313 | LDH-Cytotoxicity Colorimetric Assay Kit II DataSheet

6736 | LDHA Antibody (Center) DataSheet

6735 | LDHA Antibody (CT) DataSheet

6737 | LDHAL6B Antibody (NT) DataSheet

LDK-378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 200 pM). It displays weaker inhibition against IGF-1R, InsR, and STK22D (IC50s = 8, 7, and 23 nM, respectively), and...

K436 | LDL Uptake Assay Kit Cell-Based DataSheet

3839BP | LDLR Blocking Peptide DataSheetAntibody Target: LDLR Accession #: P01130Gene ID: 3949Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

LDN-192960 dihydrochloride is an inhibitor of Haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. It...

LDN-193189 inhibits transcriptional activity of the (Bone Morphogenetic Protein) BMP type I receptors known as activin receptor-like kinases (ALKs). It inhibits ALK2 and ALK3 with IC₅₀ values of 5 nM...

LDN-193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the...

LDN-212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Displays selectivity for ALK2 over ALK4 and ALK5 in...

Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins...

Cell-permeable. LDN193189 is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 functions...

A 10 mM (5 mg in 1.13 ml) solution of LDN193189 (Cat. No. 1995-5) in anhydrous DMSO.EZSolution™ LDN193189 is a 10 mM (5 mg in 1.13 ml) solution of LDN193189 (Cat. No. 1995-5) in anhydrous DMSO.2092 |...

Ledipasvir is a potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Upon oral administration and after...

Leelamine is a diterpene molecule that displays weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a...

Cell-permeable. An immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for...

Leniolisib is a potent and selective PI3Kδ inhibitor with an IC₀ of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively; shows 30-fold cellular...

K1306 | Lentivirus Maxi Purification Kit DataSheet

K1305 | Lentivirus Mini Purification Kit DataSheet

Lenvatinib is a potent inhibitor of multiple receptor tyrosine kinases, with IC₅₀ values of 22 nM, 4 nM, 5.2 nM, 39 nM and 35 nM on VEGFR-1, VEGFR-2, VEGFR-3, PDGFRβ and RET, respectively. It...

5366 | Leptin Antibody DataSheet

E4653 | Leptin Human ELISA Kit DataSheet

E4654 | Leptin Mouse Elisa Kit DataSheet

E4655 | Leptin Rat Elisa Kit DataSheet

5582 | Leptin Receptor Antibody DataSheet

Leptin receptor (LEPR), also known as OB-R and B219, is a single transmembrane-domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high...

A 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback...

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate...

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate...

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate...

A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein...

Lersivirine is a non-nucleoside, next generation reverse transcriptase inhibitor (IC50 = 118 nM for the wild-type HIV-1 enzyme). It inhibits a panel of 14 single-point mutant HIV-1 reverse...

Lesinurad (RDEA-594) sodium is a selective uric acid reabsorption inhibitor (SURI). Lesinurad sodium also inhibits the uric acid transporter URAT1 and Kidney transporter OAT with IC50/Km of 4.3 μM/0...

An indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC₅₀ values of 3, 1, and

Letrozole is a third-generation nonsteroidal cell-permeable aromatase inhibitor (IC₅₀ = 2 nM). It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of...

A potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems...

K534 | Leucine Aminopeptidase LAP Activity Assay Kit Fluorometric DataSheet

LRG1 binds cytochrome c, an initiator/amplifier of programmed cell death (apoptosis), and by binding cytochrome c, is thought to play a role in cell survival. LRG1 is a biomarker associated with...

A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse...

A microbial product. A reversible inhibitor of serine and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B.Leupeptin, hemisulfate is a reversible inhibitor of serine and cysteine...

Synthetic Human Leuprolide is a single, non-glycosylated, polypeptide chain containing 9 amino acids and having a molecular mass of 1209 Dalton.4787 | Leuprolide DataSheetBiomolecule/Target:...

Lexibulin is an orally available inhibitor of microtubule polymerization with an IC₅₀ of 3 µM. It blocks cell cycle at the G2-M phase, which leads to cell death. It is cytotoxic to various cell lines...

LF3 is a potent inhibitor of canonical Wnt signaling pathway (IC₅₀ < 2 µM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in...

FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK). It has also been shown to inhibit Polo-like kinase (PLK) (IC₅₀ = 61 µM...

LGD-4033 | B2403

LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models,...

LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent...

Licochalcone A is a natural chalcone isolated originally from roots and rhizomes of licorice (Glycyrrhiza spp.). It has anti-inflammatory properties, supporting its use as a skin lightening agent...

Licogliflozin is a dual inhibitor of Sodium/glucose cotransporters SGLT1 and SGLT2 with a higher selectivity for SGLT2 (in vitro IC₅₀ values of 20.6 and 0.58 nM, respectively). It causes a reduction...

5216 | LIF Antibody DataSheet

Leukemia Inhibitory Factor (LIF) is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has several functions such as...

Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has...

Lifitegrast is a LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is...

K4203 | LIFR Human Elisa Kit DataSheet

5607 | LIGHT Antibody DataSheet

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTR, or bind to a decoy receptor, DcR3. It is expressed in...

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTR, or bind to a decoy receptor, DcR3. It is expressed in...

LIMK1 Antibody | 3433

3584 | LIMK2 Antibody DataSheet

LIMKi 3 is a potent, and cell-permeable inhibitor of LIMK1 (IC₅₀ = 7 nM) and LIMK2 (IC₅₀ = 8 nM) and inhibits coflin phosphorylation in MDA-MB-231 breast cancer cells without affecting tubulin...

3091 | Lin28 antibody DataSheet

3091BP | Lin28 Blocking Peptide DataSheetAntibody Target: Lin28Accession #: N/AGene ID: N/AAppearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

LIN28 is an RNA-binding protein that regulates the maturation of the let-7 microRNAs through its two distinct cold shock and zinc-knuckle domains. LIN28 inhibitor LI71 binds the cold shock domain of...

Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an...