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A potent, reversible, small molecule inhibitor of kinesin spindle protein (KSP), a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through...

SB-742457 is a highly selective 5-HT6 receptor antagonist with potential cognition, memory and learning-enhancing effects; displays >100-fold selectivity over other receptors. in anxiolytic and...

SB-743921 hydrochloride is potent kinesin spindle protein (KSP) inhibitor (Ki = 0.1 nM). Displays almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4, and CENP-E. Induces cell mitotic arrest...

SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 with IC50 of 13, 73, and 56 nM, respectively. SB1317 may be useful for the treatment of cancer that crosses the blood brain barrier and acts by...

A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I₅₀ = 23 nM) and FLT3 (IC₅₀ = 22 nM). SB1518 displays potent anti-proliferative effects on myeloid and lymphoid cell lines...

SB239063 is a potent and selective p38 MAPK inhibitor with an IC50 of 44 nM against p38α MAPK while exhibited no activity against the γ- and δ-kinase isoforms.SB239063 is a potent and selective p38...

SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), lowering cholesterol levels in mice.SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin...

SBE13 HCl is a potent and selective PLK1 (Polo-like kinase 1) inhibitor (IC₅₀ = 200 pM). Displays activity against PLK2 and PLK3 at higher concentrations (IC₅₀ values of 66 µM and 875 nM,...

SBHA is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC₅₀ = 0.25 μM) and HDAC3 (IC₅₀ = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or...

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965...

SBI-115 is a potent TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.SBI-115 is a potent TGR5 (GPCR19) antagonist. SBI-115 decreases...

SBI-797812 is a novel nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to...

3986 | SBP-Tag Antibody DataSheet

3986BP | SBP-Tag Blocking Peptide DataSheetAntibody Target: SBP-Tag Accession #: N/AGene ID: N/AAppearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties...

A reversible, competitive inhibitor of IKK2 (IC₅₀ = 11.2 µM). Does not inhibit other IKK isoforms, or other kinases. Displays dose-dependent inhibition of the transcription of NK-κB dependent genes...

SC-75741 | B3361Description: SC-75741 is a potent NF-κB inhibitor (EC50 = 200 nM) that efficiently blocks influenza virus propagation. The mechanism of SC-75741 action involves impaired DNA binding...

SC-79 is an Akt activator. Binds to the pleckstrin homology (PH) domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by...

Cell-permeable. An allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin...

3875BP | SCD Blocking Peptide DataSheetAntibody Target: SCDAccession #: NP_114029Gene ID: 83792Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1,

The Semaphorins are a large family of phylogenetically conserved proteins that play a pivotal role in maintaining homeostasis in the immune system. Twenty members of this family have been identified...

CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted...

CD23, the low affinity receptor for IgE, belongs to the C-type lectin structural family and plays a role in the regulation of IgE synthesis and IgE mediated activities. It is found both as a...

CD27 Ligand, a type II transmembrane protein, is a member of the TNF superfamily. It is expressed on activated T and B lymphocytes as well as NK cells. CD27L and its receptor (CD27) regulate the...

CD30 ligand (CD30L) is a type-II membrane-associated glycoprotein protein belonging to the TNF superfamily and is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds...

CD34 is a highly glycosylated type I membrane protein that is selectively expressed on hematopoietic stem cells and vascular endothelium. It has been widely used as a molecular marker for the...

5328 | SCF Antibody DataSheet

Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors...

Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors...

Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors...

K4183 | SCFR/c-Kit Human Elisa Kit DataSheet

SCGF alpha and beta are hematopoietic growth factor that exerts their activity at early stages of hematopoiesis. The SCGFs are non-glycosylated species-specific cytokines that can support growth of...

SCGF alpha and beta are hematopoietic growth factor that exerts their activity at early stages of hematopoiesis. The SCGFs are non-glycosylated species-specific cytokines that can support growth of...

SCH-28080 is a potent H+, K+-ATPase inhibitor (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo.SCH-28080 is...

SCH-529074 is a small molecule activator of mutant p53. It binds specifically to the p53 DBD (DNA binding domain) in a saturable manner with an affinity of 1-2 µM. Binding restores wild type function...

SCH-58261 is the adenosine (A2A) receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.SCH-58261 is the adenosine (A2A) receptor...

SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.B1682 |...

Glutathione S-transferase (GST) represents a major group of detoxification enzymes. It acts by catalyzing the reaction of glutathione with an acceptor molecule to form an S-substituted glutathione...

An antibiotic Isolated from fungus Penicillium sp. Cholesteryl ester transfer protein (CETP) activity inhibitor (IC₅₀ = 19.4 µM). Weak antagonist of human endothelin receptor A (ETA) and B (ETB). A...

SCR7 pyrazine is a potent inhibitor of nonhomologous endjoining (NHEJ) mediated by DNA ligase IV. Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro.SCR7 pyrazine is a...

’s Screw Caps are molded of high-purity, low metal-content polypropylene copolymer resin. The Screw caps are pressure-tested together at 7.5 psig for safe air shipment. M1353 | Screw Caps...

A Negative control compound for the histone deacetylase (HDAC) inhibitor Scriptaid (Cat. No. 1605-1).script is a negative control compound for the histone deacetylase (HDAC) inhibitor Scriptaid (Cat...

A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-β/Smad4) in both stable and transient receptor assays in a concentration-dependent manner...

SD208 is a potent, ATP-competitive transforming growth factor-β receptor 1 (TGF-βR1) kinase inhibitor (IC₅₀ = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common...

SDF-1 alpha and beta are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem...

Human Stromal Cell-Derived Factor-1 (SDF-1) is a recently discovered protein belonging to the -chemokine (C-X-C) family of cytokines. Human SDF-1 is an 8.0 kDa protein containing 68 amino acids...

Stromal Cell-Derived Factor-1 (SDF-1) is a recently discovered protein belonging to the -chemokine (C-X-C) family of cytokines. Recombinant murine SDF-1 is a 7.9 kDa protein containing 68 amino acids...

5387 | SDF-1alpha Antibody DataSheet

Stromal cell-derived factor-1 is a stromal derived CXC chemokine. It signals through CXCR4 receptor. Recombinant Human SDF-1 is an 8.5 kDa protein containing 72 amino acid residues.4390 | SDF-1beta...

Stromal cell-derived factor-1 is a stromal derived CXC chemokine. It signals through CXCR4 receptor. Recombinant murine SDF-1 is an 8.5 kDa protein containing 72 amino acid residues.4391 | SDF-1beta...

5390 | SDF-1beta Antibody DataSheet

5390BP | SDF-1beta Blocking Peptide DataSheetAntibody Target: SDF-1beta Accession #: P48061Gene ID: 6387Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Stromal Derived Growth Factor-1beta (SDF-1beta), also called CXCL12, is one of two splice variants made by a wide variety of cells when stimulated by inflammatory cytokines such as, TNF, IL-1 or LPS...

SDF-1 alpha and beta are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem...

6691 | SDF1 alpha Antibody DataSheet

A 10% solution of sodium dodecylsulfate (SDS) in water.2102 | SDS Solution DataSheetSort Name: SDS SolutionLabel Name: N/ATaglines: 10% SDS solutionProduct Highlights: • Alternate Name/Synonyms:...

A1054BP | Secretin Blocking Peptide DataSheetAntibody Target: SCTAccession #: P09683Gene ID: 6343Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in PBS (pH 7.2)...

A1054 | Secretin Polyclonal Antibody DataSheet

Human Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the production of gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes...

3871 | SEK1/MKK4/JKK1 Antibody DataSheet

3871BP | SEK1/MKK4/JKK1 Blocking Peptide DataSheetAntibody Target: SEK1/MKK4/JKK1Accession #: EDL10407Gene ID: 26398Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml)...

Bovine serum albumin (BSA) is a common endocytic cargo, which typically ends up being degraded by proteases in the lysosome. Our Self-Quenched BODIPY FL Conjugate of BSA (Green) is a derivative of...

Gelatin consists of a heterogeneous mixture of high molecular weight proteins derived from collagen. These proteins can be cleaved by different cellular enzymes. Self-Quenched BODIPY conjugate of...

Selonsertib is a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the...

Selpercatinib is a RET kinase inhibitor with IC₅₀ values ranging from 1 nM to 4 nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven...

A potent γ-secretase inhibitor (IC₅₀ = 10.9 nM, 12.1 nM and 12.0 nM for Aβ42, Aβ40 and Aβ38, respectively). Semagacestat has shown to reduce the rate of formation of amyloid-β in vitro and in vivo...

Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R). It is a glucagon-like peptide-1 (GLP-1) analogue approved for the treatment of type 2 diabetes mellitus. It has two amino acid...

Semaphorins are a large group of structurally related secreted, GPI-anchored and transmembrane cell signaling molecules. There are 8 major classifications (1-7) of Semaphorins characterized by the...

K320 | Senescence Detection Kit DataSheet

K991 | Senescence Detection Kit Fluorometric DataSheet

Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker (IC₅₀ = 11 nM). Senicapoc (ICA-17043) could be a potential drug for the prevention and treatment of hemolysis-associated...

Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117...

E4294 | Serotonin Elisa Kit DataSheet

3906 | Serpin A6 Antibody DataSheet

3906BP | Serpin A6 Blocking Peptide DataSheetAntibody Target: Serpin A6 Accession #: NP_001009663Gene ID: 299270Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. They are the largest and most diverse family of serine protease...

A selective serotonin reuptake inhibitor and an antidepressant. Sertraline suppresses platelet function and displays antiplatelet and endothelium protective functions. It relieves depression and...

E4307 | Serum amyloid P-component APCS Human Elisa Kit DataSheet

Sesamolin is a furofuran lignan extracted from sesame seeds. It displays beneficial biological properties such as antioxidant, anti-mutagenic, anti-aging and anti-inflammatory activities. Also known...

6841 | Set9 polyclonal antibody DataSheet

6842 | Setd1a polyclonal antibody DataSheet

6843 | Setd1b polyclonal antibody DataSheet

3197 | SETD3 Antibody DataSheet

3197BP | SETD3 Blocking peptide DataSheetAntibody Target: SETD3Accession #: Q86TU7Gene ID: 84193Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

6844 | SETD8 polyclonal antibody DataSheet

6155 | SETDB1 Antibody DataSheet

SF-2523 is a potent and highly selective inhibitor of PI3K and BRD4 with IC₅₀ values of 16 and 241 nM for PI3Kα and BD1, respectively.SF-2523 is a potent and highly selective inhibitor of PI3K and...

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular...

Mouse SF20 is a bone marrow stroma-derived growth factor. SF20 is expressed in the bone marrow, spleen stroma cells, resting mononuclear cells, resting CD8+ and CD19+ cells and activated CD8+ T cells...

Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells. Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells. FasL has the...

Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism...

SFTPD, as known as Surfactant pulmonary-associated protein D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the...

SGC-CBP30 is a potent and selective CREBBP/EP300 bromodomain inhibitor with IC values of 21-69 and 38 nM for CREBBP and EP300 bromodomains, respectively. SGC-CBP30 has little activity against other...

A potent and selective DOT1L inhibitor (IC₅₀ = 0. 3 nM in a radioactive enzyme assay); >100-fold selective for other histone methyltransferases (HMTs). SGC0946 also potently reduces H3K79...

SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a...

SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with...

SGI-1776 is a potent and ATP-competitive Pim kinase inhibitor (IC₅₀’s = 7, 363, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively). SGI-1776 also inhibits FLT3 (IC₅₀ = 44 nM). Induces apoptosis in...

SGI-7079 is a potent and selective Axl inhibitor with potential anticancer activity. SGI-7079 significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC₅₀ of 0.43 or 0.16 μM,...

3459 | SGK Antibody DataSheet