Angiostatin K1-3, human recombinant | 4920

Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED =70 nM) relative to kringles 1-4 (ED = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.

4920 | Angiostatin K1-3 human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Angiostatin K1-3, Angiostatin Kringles 1-3

Alternates names: Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen

Taglines: A specific inhibitor of endothelial cell growth and angiogenesis

NCBI Gene ID #:

NCBI Gene Symbol: TNFSF13B

Gene Source: Human

Accession #: D4AAC1

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: 0.55×10 Units/mg.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 20.7 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from a 0.2 m filtered solution of 20 mM Sodium Acetate, pH 5.5 and 4% mannitol.

Reconstitution Instructions: Reconstitute in sterile HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A