BMPR1B Antibody| F41873-0.08ML/F41873-0.4ML/R31125

BMPR1B Antibody| F41873-0.08ML/F41873-0.4ML/R31125 | Gentaur UK, US & Europe Distribution

Background: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50

Application Note: Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This BMPR1B antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 134-162 from the human protein was used as the immunogen for this BMPR1B antibody.

Storage: Aliquot the BMPR1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A