Cathepsin L (Active), Human Liver | 7539

Cathepsin L (Active), Human Liver | 7539

Description: Cathepsin L is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Substrates for Cathepsin L include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L has been implicated in myofibril necrosis in some muscle diseases, and in the renal tubular response to proteinuira. Levels of Cathepsin L is a strong predictor of relapse and survival following primary breast tumor treatment. Recently, Cathepsin L has been shown to cleave the S1 subunit of the SARS-CoV-2 spike protein, which allows viral intry into the cell.

Biomolecule/Target:

Synonyms: Cathepsin L1; Major Excreted Protein; CTSL; CTSL1

Alternates names:

Taglines: Plays a major role in intracellular protein catabolism

NCBI Gene ID #: 1514

NCBI Gene Symbol: Human

Accession #: P07711

Recombinant: False

Source: Human liver

Purity by SDS-PAGE:

Assay:

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method): Greater than 1 unit per mg of protein, where one unit is defined as the amount of enzyme needed to hydrolyze one micromole of Z-Phe-Arg-AFC per minute at 25 C using 400 mM sodium acetate, pH 5.5. with 4 mM EDTA and 8 mM DTT as the activation buffer in the presence of Brij detergent.

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 25 to 29 kDa

Concentration:

Appearance: Sterile Filtered colorless solution

Physical form description: Frozen

Reconstitution Instructions:

Amino acid sequence:

Handling: Centrifuge the vial prior to opening.

Usage: