CD45 Antibody| F44586-0.08ML/F44586-0.4ML/R30674

CD45 Antibody| F44586-0.08ML/F44586-0.4ML/R30674 | Gentaur UK, US & Europe Distribution

Background: CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. The CD45 gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, FACS, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50, Flow Cytometry: 1:10-1:50

Application Note: Titration of the CD45 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This CD45 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 1245-1275 from the human protein was used as the immunogen for this CD45 antibody.

Storage: Aliquot the CD45 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A