H-89 Dihydrochloride | 1768

A cell-permeable, ATP-competitive inhibitor of Protein Kinase A (PKA) (IC₅₀ = 50 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII with IC₅₀ values of 120 nM, 80 nM and 270 nM respectively.

H-89 is a cell-permeable, ATP-competitive inhibitor of Protein Kinase A (PKA) (IC₅₀ = 50 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII with IC₅₀ values of 120 nM, 80 nM and 270 nM respectively.

1768 | H-89 Dihydrochloride DataSheet

Alternate Name/Synonyms: N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-Isoquinolinesulfonamide dihydrochloride

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 127243-85-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₀BrN₃O₂S.2HCl

Molecular Weight: 519.28

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (200 mg/ml) and H₂O (25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A protein kinase A (PKA) inhibitor

MDL Number: MFCD11045926

PubChem CID: 5702541

SMILES: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br.Cl.Cl

InChi: InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;;

InChi Key: GELOGQJVGPIKAM-WTVBWJGASA-N