HC Toxin | 2728

HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells

HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells

2728 | HC Toxin DataSheet

Alternate Name/Synonyms: (6R,​9S,​14aR)-​3,​6R-​dimethyl-​9S-​(6-​((S)-​oxiran-​2-​yl)-​6-​oxohexyl)decahydropyrrolo[1,​2-​a][1,​4,​7,​10]tetraazacyclododecine-​1,​4,​7,​10-​tetranone; Toxin I (Helminthosporium carbonum)

Appearance: White solid

Formulation: N/A

CAS Number: 83209-65-8

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₃₂N₄O₆

Molecular Weight: 436.5

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A histone deacetylase (HDAC) inhibitor

MDL Number: MFCD00133388

PubChem CID: 23724535

SMILES: O=C(C1CO1)CCCCC[C@@H](C(N2[C@]3([H])CCC2)=O)NC([C@@H](C)NC([C@H](C)NC3=O)=O)=O

InChi: InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1

InChi Key: GNYCTMYOHGBSBI-KVUCBBCISA-N