Description
HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells
HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells
Alternate Name/Synonyms: (6R,9S,14aR)-3,6R-dimethyl-9S-(6-((S)-oxiran-2-yl)-6-oxohexyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone; Toxin I (Helminthosporium carbonum)
Appearance: White solid
Formulation: N/A
CAS Number: 83209-65-8
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₃₂N₄O₆
Molecular Weight: 436.5
Cell-Permeable?: Yes
Purity: ≥95%
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A histone deacetylase (HDAC) inhibitor
MDL Number: MFCD00133388
PubChem CID: 23724535
SMILES: O=C(C1CO1)CCCCC[C@@H](C(N2[C@]3([H])CCC2)=O)NC([C@@H](C)NC([C@H](C)NC3=O)=O)=O
InChi: InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1
InChi Key: GNYCTMYOHGBSBI-KVUCBBCISA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |