Human CellExp™ LRRC32 / GARP, Fc Tag, Human Recombinant | P1207

Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.

P1207 | Human CellExp LRRC32 / GARP Fc Tag Human Recombinant DataSheet

Biomolecule/Target: LRRC32

Synonyms: GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant

Alternates names: IDL

Taglines: Binds to TGF-beta to suppress naïve T cell proliferation.

NCBI Gene ID #: 4035

NCBI Gene Symbol: LRP1

Gene Source: N/A

Accession #: Q07954

Recombinant: Yes

Source: Human plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/g

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized Latent TGFB1, N-His at 5 g/mL (100 L/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 g/mL.

Unit Definition: N/A

Molecular Weight: 5.0-10,000.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: N/A