IRF9 Antibody| F41756-0.08ML/F41756-0.4ML

IRF9 Antibody| F41756-0.08ML/F41756-0.4ML | Gentaur UK, US & Europe Distribution

Background: IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: N/A

Application: WB, IHC, IF, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50

Application Note: Titration of the IRF9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This IRF9 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 75-104 from the human protein was used as the immunogen for this IRF9 antibody.

Storage: Aliquot the IRF9 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A