NEDD8 Antibody| F42040-0.08ML/F42040-0.4ML/R32590

NEDD8 Antibody| F42040-0.08ML/F42040-0.4ML/R32590 | Gentaur UK, US & Europe Distribution

Background: NEDD8 is a ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Bovine, Rabbit

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100

Application Note: Titration of the NEDD8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This NEDD8 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 1-32 from the human protein was used as the immunogen for this NEDD8 antibody.

Storage: Aliquot the NEDD8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A