Description
PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC₅₀ =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.
PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC₅₀ =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.
Alternate Name/Synonyms: N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide
Appearance: White solid
Formulation: N/A
CAS Number: 918505-84-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₄ClF₂N₃O₃S
Molecular Weight: 413.83
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>80 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP-competitive B-raf inhibitor
MDL Number: MFCD14635203
PubChem CID: 24180719
SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
InChi: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
InChi Key: YZDJQTHVDDOVHR-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |