PLX-4720 | 2813

PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC₅₀ =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.

PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC₅₀ =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.

2813 | PLX-4720 DataSheet

Alternate Name/Synonyms: N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide

Appearance: White solid

Formulation: N/A

CAS Number: 918505-84-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄ClF₂N₃O₃S

Molecular Weight: 413.83

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>80 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive B-raf inhibitor

MDL Number: MFCD14635203

PubChem CID: 24180719

SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F

InChi: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)

InChi Key: YZDJQTHVDDOVHR-UHFFFAOYSA-N