Description
WHI-P154 is a potent JAK3 inhibitor (IC₅₀ of 1.8 μM). It displays no activity against JAK1 or JAK2. Also inhibits EGFR, Src, Abl, VEGFR and MAPK, and prevents Stat3, but not Stat5 phosphorylation. Induces differentiation of neural progenitor cells
WHI-P154 is a potent JAK3 inhibitor (IC₅₀ of 1.8 μM). It displays no activity against JAK1 or JAK2. Also inhibits EGFR, Src, Abl, VEGFR and MAPK, and prevents Stat3, but not Stat5 phosphorylation. Induces differentiation of neural progenitor cells
Alternate Name/Synonyms: 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 211555-04-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₄BrN₃O₃
Molecular Weight: 376.2
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>35 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent JAK3 inhibitor
MDL Number: N/A
PubChem CID: 3795
SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC
InChi: InChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)
InChi Key: CBIAKDAYHRWZCU-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |