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A flavonoid compound that displays antioxidant, anti-inflammatory and anti-tumor properties. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1...

LW6 is a potent HIF-1 inhibitor (IC₅₀ = 4.4 μM). It promotes proteasomal degradation of HIF-1α via upregulation of von-Hippel-Landau (VHL) without affecting the activity of prolyl hydroxylase (PHD)...

LX-2343 is a neuroprotective agent for the treatment of Alzheimer's disease. LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance...

LX-4211 is a potent dual sodium-glucose cotransporter (SGLT)1 and SGLT2 inhibitor and an anti-diabetic agent. Sotagliflozin significantly improves glycemic control, without increasing the rate of...

3641 | LXR Antibody DataSheet

3641BP | LXR Blocking Peptide DataSheetAntibody Target: LXR Accession #: Q13133Gene ID: 10062Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

LXR-623 is a potent and selective LXR (liver X receptor) agonist. Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and...

LXS-196 is an orally available protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Upon oral administration, LXS-196 binds to and inhibits PKC, which...

A specific and cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 1.40 µM).LY 294002 is a specific and cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI...

LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.B1734 | LY 303511...

LY-2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 1.5 NM for GSK-3α and 0.9 nM for GSK-3β). LY-2090314 plays an important role in many...

LY-2109761 is a highly potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor with Ki of 38 nM and 300 nM respectively. It has been used to study the role of TGF-β signaling in...

LY-2157299 is a potent and selective TGFβ receptor I (TβRI) inhibitor (IC₅₀ = 56 nM). LY-2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. It also shows dose dependent...

LY-2409881 is a potent and selective inhibitor of IκB kinase β (IKK2; IC50 = 30 nM). It inhibits IKK1 and other common kinases only at ≥10-fold higher concentrations. LY2-409881 inhibits...

LY-2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY-2510924 binds to the chemokine receptor...

LY-2584702 is a potent, ATP-competitive inhibitor of p70S6K signaling, with potential antineoplastic activity. LY-2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation...

LY-2603618 is a potent, selective and ATP-dependent inhibitor of checkpoint kinase 1 (Chk1) (IC₅₀ = 7 nM). It inhibits Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation...

LY2784544 is a potent, selective and ATP-competitive JAK2 inhibitor (IC₅₀ = 3 nM). effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. LY2784544 effectively inhibits...

LY-2795050 is a potent and selective κ-opioid Receptor (KOR) antagonist (IC₅₀ = 0.72 nM). Has the potential as a PET tracer to image KOR in vivo.LY-2795050 is a potent and selective κ-opioid Receptor...

LY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC₅₀ of 2 nM and 10 nM, respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates...

LY-2874455 is a potent, FGF/FGFR inhibitor. Exhibits potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in...

LY-2940680 binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling pathway. Displays anticancer properties.LY-2940680 binds to the Smoothened (Smo) receptor and potently...

LY-310762 is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 249 nM for guinea pig receptors). It is selective for 5-HT1D over the 5-HT1B receptor, where it inhibits binding...

LY-3200882 is a potent and ATP-competitive inhibitor of TGF-β receptor type 1 (TGF-βRI). It inhibits TGF-β-induced SMAD phosphorylation in vitro and in vivo and exhibits antitumor activity in the...

An isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Inhibits both the PKCβI (IC₅₀ = 4.7 nM) and PKCβII (IC₅₀ = 5.9 nM) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of...

LY-3381916 is a potent, selective and brain permeant IDO1 (Indoleamine 2,3-Dioxygenase1) inhibitor. LY-3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation...

LY341495 is a potent, brain-permeable, and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC₅₀s = 21 and 14 nM, respectively, for human isoforms)...

LY411575 is a potent, cell-permeable γ-secretase inhibitor (IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC₅₀ of 0.39 nM. Notch inhibition using LY-411575...

LY-83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC₅₀ value of 2 µM. Also blocks the release of...

LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, but does not alter p38 MAPK activation.LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of...

LY2608204 is a potent activator of glucokinase (GK) with EC₅₀ of 42 nM. Potential antidiabetic agent to treat type 2 diabetes.LY2608204 is a potent activator of glucokinase (GK) with EC₅₀ of 42 nM...

LY2811376 is a BACE1 inhibitor with marked Ab-lowering effects in animal models.LY2811376 is a BACE1 inhibitor with marked Ab-lowering effects in animal models.B1606 | LY2811376 DataSheetAlternate...

Cell-permeable. A potent and selective β-secretase (BACE-1) inhibitor (IC₅₀ = 20 nM for recombinant hBACE1). Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A...

LY3023414 is a small molecule that has been shown in vitro to be a selective ATP-competitive inhibitor of PI3Kα and mTOR, DNA-PK, and other class I PI3K family members.LY3023414 is a small molecule...

LY315920 is a potent, and selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) (IC₅₀ = 9± 1 nM). Potential anti-inflammatory agent.LY315920 is a potent, and...

LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage...

LY404187 is a selective, potent and centrally active positive allosteric modulator of AMPA receptors. It preferentially acts at recombinant human homomeric GluR2 and GluR4 versus GluR1 and GluR3 AMPA...

A potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism...

Lycorine is a naturally occurring alkaloid found in plants in the Amaryllidaceae family; it displays antifungal, anti-parasitic, and anticancer activities. Acts as a selective inhibitor of peptidyl...

Lymphoprep™ is a ready-made, sterile, endotoxin-tested, separation medium for isolating human mononuclear cells (lymphocytes and monocytes), especially from blood. Relatively low buoyant...

5376 | Lymphotactin Antibody DataSheet

Lymphotactin is part of the C family chemokines that exhibit chemotactic activity toward lymphocytes but not toward monocytes or neutrophils. Recombinant Human lymphotactin is a 10 kDa protein...

Lyn is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck and the v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization...

Lys01 trihydrochloride (Lys05) is a potent, water-soluble lysosomal autophagy inhibitor with IC₅₀ values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.Lys01...

Lysine-specific Demethylase Inhibitor (1C) inhibits Lysine-specific demethylase 1 (LSD1). LSD1 removes methyl groups from histones. The inhibitor LSD 1C increased H3K4me1 and H3K4me2, without...

K735 | Lysophosphatidylcholine Assay Kit Colorimetric/Fluorometric DataSheet

K458 | Lysosomal Cytotoxicity Dual Staining Kit Cell-Based DataSheet

K448 | Lysosomal Intracellular Activity Assay Kit DataSheet

K187 | Lysosomal α-Glucosidase GAA Activity Assay Kit Fluorometric DataSheet

K235 | Lysosome Purification Kit DataSheet

K236 | Lysozyme Activity Assay Kit Fluorometric DataSheet

A1110 | Lysozyme Antibody DataSheet

K4243 | Lysozyme Elisa Kit DataSheet

K237 | Lysozyme Inhibitor Screening Kit DataSheet

Lysozyme is a glycoside hydrolase which hydrolyzes 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in...

K928 | Lysyl Oxidase Activity Assay Kit Fluorometric DataSheet

M-3814 Nedisertib | B2217

5237 | M-CSF Antibody DataSheet

Macrophage Colony stimulating Factor (M-CSF) is produced by various cell types, including fibroblasts, microphages, and endothelial cells. M-CSF is involved in both the development and function of...

Macrophage Colony stimulating Factor (M-CSF) is produced by various cell types, including fibroblasts, microphages, and endothelial cells. M-CSF is involved in both the development and function of...

An amide analog of Trichostatin A (Cat.# 1606-1) that potently Inhibits histone deacetylases (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HDAC). Induces differentiation and inhibits...

Macitentan is an orally active endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH).Macitentan is an orally active endothelin receptor antagonist...

Macrosphelide A is a macrolide antibiotic. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It inhibits the...

3765 | MAD1 Antibody DataSheet

3766 | MAD2 Antibody DataSheet

Madrasin is a potent and cell-permeable pre-mRNA splicing inhibitor. It interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.Madrasin is a...

Maduramicin is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is commonly used in veterinary medicine as an anti-coccidial agent. It is cytotoxic...

04820 | MAGE-1 human recombinant DataSheetBiomolecule/Target: N/ASynonyms: Melanoma-associated antigen 1, MAGE-1 antigen, Antigen MZ2-E, Cancer/testis antigen 1,1, CT1,1, MAGEA1, MAGE1, MAGE1A,...

Melanoma-associated antigen 3, also known MAGEA3, is a member of the MAGE gene family, which comprises 12 known genes, of which 6 are expressed in tumors. The MAGE genes were initially isolated from...

Provided as a stock solution for making various biological buffers and salt solutions2105 | Magnesium Chloride (MgCl₂) DataSheetSort Name: Magnesium Chloride (MgCl₂)Label Name: N/ATaglines: 1M MgCl2...

K385 | Magnesium Colorimetric Assay Kit DataSheet

’s Magnetic Beads for DNA Purification are paramagnetic particles coated with carboxyl groups that can reversibly bind to DNA. The magnetic beads are formulated to specifically bind to DNA and remove...

’s Magnetic Separation Rack is used to capture and separate magnetic beads used in magnetic beads based purification techniques. The rack captures magnetic beads which may be bound to DNA, viruses or...

The powerful Magnetic Separator allows efficient magnetic separation using 1.5 ml, 15 ml, and 50 ml centrifuge tubes. The magnetic separator uses permanent, extremely strong, rare earth magnets...

MAK-683 is a potent EED (embryonic ectoderm development protein) inhibitor and an allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. MAK683...

3134 | MAK10 antibody DataSheet

3134BP | MAK10 Blocking Peptide DataSheetAntibody Target: MAK10Accession #: Q6DKG0Gene ID: 64472Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

K637 | Malate Colorimetric Assay Kit DataSheet

K654 | Malate Dehydrogenase Activity Colorimetric Assay Kit DataSheet

Maleimide Activated Alkaline Phosphatase is commonly used to facilitate the conjugation of alkaline phosphatase to proteins, peptides and ligands containing sulfhydryl (-SH) groups for using it as an...

Maleimide Activated BSA commonly used as a carrier protein for haptens (small molecules/low molecular weight molecules and peptides) in order to enable the immune response. BSA is the most popular...

Maleimide Activated Horseradish Peroxidase (HRP) is commonly used to facilitate the conjugation of HRP to proteins, peptides and ligands that contain sulfhydryl (-SH) groups for use as an...

Maleimide Activated KLH commonly used as a carrier protein for haptens (small molecules/low molecular weight molecules and peptides) in order to enable the immune response. KLH is the most popular...

Maleimide Activated OVA commonly used as a carrier protein for haptens (small molecules/low molecular weight molecules and peptides) in order to enable the immune response to the small molecules. ’s...

Maleimide Activated Streptavidin is commonly used to facilitate the conjugation of streptavidin to proteins, peptides and ligands containing sulfhydryl (-SH) groups for using it as an enzyme-linked...

Malformin A is a cyclopentapeptide fungal metabolite that displays diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits...

MALT1 inhibitor MI-2 is a potent inhibitor of the paracaspase MALT1 (Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) (IC₅₀ = 5.84 μM). MI-2 binds directly to MALT1 and irreversibly...

K618 | Maltose and Glucose Colorimetric/Fluorometric Assay Kit DataSheet

6715 | Maltose Binding Protein - Tag (MBP-Tag) Antibody (Clone 17D07) DataSheet

K628 | Maltose Colorimetric/Fluorometric Assay Kit DataSheet

Mambalgin-1 is a peptide toxin originally isolated from the venom of Black Mamba (Dendroaspis polylepis polylepis). Acts as an analgesic. Mambalgin-1 is able to abolish pain through inhibition of...

K269 | Mammalian Cell Extraction Kit DataSheet

K967 | Mammalian Cell Genomic DNA Isolation Kit DataSheet

K288 | Mammalian Mitochondria Isolation Kit For Tissue & Cultured Cells DataSheet

An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect...

MAO-A/MAO-B inhibitor is a coumarin derivative which inhibits monoamine oxidases MAO-A and MAO-B with an IC₅₀ of 235 ± 18.52 nM and 165 ± 7.04 nΜ, respectively.MAO-A/MAO-B inhibitor is a coumarin...

3694 | MAP-1 Antibody DataSheet

3694BP | MAP-1 Blocking Peptide DataSheetAntibody Target: MAP-1 Accession #: Q9ERH6Gene ID: 64113Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3100 | MAPKAPK-2 Antibody DataSheet

3100BP | MAPKAPK-2 Blocking Peptide DataSheetAntibody Target: MAPKAPK-2 Accession #: P49137Gene ID: 9261Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...