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K204 | Intracellular Hydrogen Peroxide Detection Kit cell-based DataSheet

K674 | Invertase Activity Colorimetric Assay Kit DataSheet

Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption...

Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption...

Cell-permeable. A histone demethylase (HDM) JMJD nhibitor. Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC₅₀s = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 µM for JMJD3, JMJD1A,...

IOX-2 is a potent, cell-permeable and selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC₅₀ = 21 nM). It displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and...

IOX3 (FG-2216) is a potent, orally bioavailable HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.9 µM for PDH2 enzyme. It has been shown to reversibly stimulate erythropoietin secretion at 100...

5200 | IP-10 Antibody DataSheet

Human IP-10 is an 8.5 kDa protein produced by several cell types during the delayed type hypersensitivity response. IP-10 acts as a chemoattractant towards monocytes, lymphocytes, and certain T cells...

Murine IP-10 is an 8.7 kDa protein produced by several cell types during the delayed type hypersensitivity response. IP-10 acts as a chemoattractant towards monocytes, lymphocytes, and certain T...

IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM). It does not, however, inhibit the activity of...

A cell-permeable indole derivative that acts as an antioxidant and mitochondrial metabolism modifier. IPAM binds to the rate-limiting component of oxidative phosphorylation in complex I of the...

IPG-1 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator for measuring changes at most intracellular K⁺ concentrations. It is a small, synthetic fluorochrome which incorporates a...

IPG-1 is a small, synthetic fluorochrome which incorporates a K⁺-binding moiety. When K⁺ binds, the quenching is relieved and the fluorescence dramatically increases. IPG-1 has Ex/Em: 525 nm/545 nm...

IPG-2 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

IPG-2 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

IPG-4 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

IPG-4 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

PI-145 is a potent inhibitor of phosphoinositide-3-kinase (PI3K)-d and PI3K-γ isoforms with potential immunomodulating and antineoplastic activities. IPI-145 prevents the activation of the...

IPI-549 is a potent and selective PI3Kγ Inhibitor (IC₅₀ of 16 nM). It displays no significant inhibition for a panel of 468 mutant and non-mutant protein and lipid kinases (including Class II PI3K...

Ipragliflozin is a potent inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC₅₀ = 7.4 nM for human SGLT2 in vitro) that increases excretion of glucose.Iipragliflozin is found to promote...

Dioxane free. Induces β-galactosidase activity in many bacteria. Functioning as a lac analog, IPTG induces β -galactosidase activity by binding to and inhibiting the lac repressor.and altering its...

Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents β-catenin from switching coactivator usage from CBP to...

IQ-1S is a potent and selective JNK3 inhibitor (IC₅₀ values are 390, 360 and 87 nM for JNK1, 2 and 3 respectively).IQ-1S is a potent and selective JNK3 inhibitor (IC₅₀ values are 390, 360 and 87 nM...

IQA is an indoloquinazoline derivative that acts as a selective and reversible casein kinase (CK2) inhibitor with an IC₅₀ of 390 nM with 100 µM ATP. It inhibits CK2 in an ATP- and GTP-competitive...

IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC₅₀ values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC₅₀ values >10 µM in a...

3580 | IRAK-4 Antibody DataSheet

IRF1, Interferon regulatory factor 1, is a member of the interferon regulatory transcription factor (IRF) family which regulates gene expression critical to immune response, hematopoiesis and...

Interferon regulatory factor (IRF) 2 is a member of the interferon regulatory transcription factor family. IRF-2 is generally regarded as an oncoprotein. Structure of IRF1 and IRF2 are similar...

3877 | IRF3 Antibody DataSheet

Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct...

An anticancer agent. This is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.Irinotecan Hydrochloride is an...

6635 | Irisin Antibody DataSheet

K4761 | Irisin Competitive Elisa Kit DataSheet

Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling...

Dp44MT is a cell-permeable iron chelator. This di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand displays potent and selective antiproliferative properties in neoplastic cells and...

K390 | Iron Colorimetric Assay Kit DataSheet

3424 | IRS-1 Antibody DataSheet

3424BP | IRS-1 Blocking Peptide DataSheetAntibody Target: IRS-1 Accession #: P35568Gene ID: 3667Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Irsogladine maleate is a potent phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. It facilitates gap junction intercellular communication through muscarinic...

ISCK03 is a cell-permeable Stem-Cell Factor/c-Kit Inhibitor that inhibits c-kit activity (IC₅₀ 90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells.ISCK03 is...

K656 | Isocitrate Colorimetric Assay Kit DataSheet

Mutations of the cytosolic IDH 1 are a common feature in primary human brain cancers. Arginine 132 (R132) of IDH is highly conserved among different isoforms of IDH and is most commonly mutated to...

K756 | Isocitrate Dehydrogenase Activity Colorimetric Assay Kit DataSheet

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants. Displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against...

Isopeptidase T is a ubiquitin-specific processing protease (UBP) that specifically disassembles free K48-linked polyubiquitin chains into ubiquitin monomers. There are two human isopeptidase T...

Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the UBPs hydrolyze isopeptide bonds between ubiquitin and the substrate protein or within polyubiquitin chains...

K698 | Isopropanol Dehydrogenase Activity Assay Kit Colorimetric DataSheet

The strong cell wall of S. aureus Protein A strain provides an excellent anchor for active Protein A molecules. After fix and kill, the cells become fine solid particles with active protein A...

Isorhamnetin | B3364Description: Isorhamnetin is a natural flavonol aglycone that displays antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM). It also competitively inhibits the...

Isorhapontigenin | B3385Description: Isorhapontigenin is a polyphenolic compound found in Chinese herbs and grapes that displays anti-inflammatory effects. Isorhapontigenin induces autophagy and...

Isoxanthohumol is a naturally occurring polyphenol isolated from hops that displays antioxidant, anti-inflammatory, and anti-angiogenic properties. It modulates angiogenesis and inflammation via...

Cell-permeable. A potent and selective voltage-gated L-type calcium channel blocker. Displays antiatherosclerotic effects and improves endothelium-mediated nitric oxide-dependent vasodilation...

Istradefylline is an adenosine receptor 2A (A2A) antagonist with a Ki value of 2.2 nM in a radioligand binding assay. Oral administration of Istradefylline reverses motor disability without inducing...

ISX9 promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory. Induces robust neuronal differentiation in adult...

An inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Inhibits the growth of bacteria expressing isocitrate lyase. A phosphofructokinase (PFKII)...

ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2),...

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). It enhances differentiation of cancer stem-like cells detected by the decrease of sphere formation and proliferation from...

ITF2357 is an orally active, hydroxamic-containing pan-histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1...

A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that...

Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses...

Ivabradine hydrochloride is a highly selective open channel blocker that targets the mixed Na⁺/K⁺ inward “funny current” (If) carried by hyperpolarization-activated cyclic nucleotide gated (HCN)...

Ivacaftor (VX-770) is a potent, cell-permeable small molecule potentiator of cystic fibrosis transmembrane conductance regulator (CFTR). It increases the forskolin-induced CFTR-mediated epithelial...

Ivachtin is a potent, reversible and non-competitive inhibitor of caspase-3 (IC₅₀ = 23 nM) that displays 10-100 fold selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T...

IVD (Isovaleryl Coenzyme A dehydrogenase) is a mitochondrial matrix enzyme that belongs to the acyl-CoA dehydrogenase family. IVD is a homotetrameric flavoenzyme which catalyzes the conversion of...

Ivermectin is an antiparasitic agent. It acts as a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.Ivermectin...

Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC₅₀ = 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the...

An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt...

IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for...

Ixazomib (MLN-2238), is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL-2238 is a biologically active form of MLN9708. MLN-2238 has an improved pharmacodynamic profile...

J 147 is a potent neuroprotective and neurotrophic compound that protects against neurotoxicity in cortical neurons in vitro (EC₅₀ = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases...

5005 | Jacalin Antibody DataSheet

Jacalin is isolated from Jackfruit seeds and purified by affinity chromatography. It is a glycoprotein with two non-covalently bound subunits (14.6 and 17.1 kDa) and belongs to the family of...

Jacalin, an alpha-D-galactose binding lectin extracted from Jackfruit seeds, binds with high specificity to human IgA1 and other o-glycoproteins such as mucin or glycopeptides. ’s high-quality...

Jade Express™ Mix | M1109

Jade Express™ Mix-iCycler | M1110

Jade Express™ Mix-Low ROX | M1111

Jade Express™ Mix-ROX | M1112

Jade Master Mix | M1105

Jade miRNA™ Mix | M1117

Jade miRNA™ Mix-iCycler | M1118

Jade miRNA™ Mix-Low ROX | M1119

Jade miRNA™ Mix-ROX | M1120

Jade Mix-iCycler | M1106

Jade Mix-Low ROX | M1107

Jade Mix-ROX | M1108

Jade Smart™ Mix | M1113

Jade Smart™ Mix-iCycler | M1114

Jade Smart™ Mix-Low ROX | M1115

Jade Smart™ Mix-ROX | M1116

's Jade™ qPCR MasterMix provides a convenient, reliable and robust setup for performing quantitative real-time analysis of DNA samples. This ready-to-use 2X qPCR MasterMix contains ’s...

Jade™ QRT Kit | M1175

Jade™ QRT Kit-iCycler | M1176

Jade™ QRT Kit-Low ROX | M1177

Jade™ QRT Kit-ROX | M1178

3101 | Jagged 1 Antibody DataSheet

3101BP | Jagged 1 Blocking Peptide DataSheetAntibody Target: Jagged 1Accession #: Q63722Gene ID: 29146Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly...

6854 | Jarid1b polyclonal antibody DataSheet

6855 | Jarid1c polyclonal antibody DataSheet