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A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays highefficacy against human and murine MLL-fusion leukemic cell lines, through...

I-BET276 is a potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC₅₀ = 41 nM), BRD3 (IC₅₀ = 31 nM), and BRD4 (IC₅₀ = 22 nM).I-BET276 is a potent, and...

I-BET762 (GSK525762) is a highly potent, selective and cell-permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 (IC₅₀ of ~35 nM). It inhibits myeloma cell...

I-BRD9 is an inhibitor and chemical probe for BRD9 bromodomain. BRD9 (bromodomain-containing protein 9) is a part of the chromatin remodeling SWI/SNF BAF complex. Bromodomain "reader" modules...

I-CBP112 is a selective CBP/EP300 bromodomain inhibitor (IC₅₀ values of 170 nM, 170 nM, 151 nM and 625 nM for CREBBP(Alphascreen), CREBBP(BLI), CREBBP(ITC) and EP300(ITC),respectively). Selective for...

i-CRT3 is a small cell-permeable oxazole derivative that acts as an inhibitor of both Wnt and β-catenin-responsive transcription.i-CRT3 is a small cell-permeable oxazole derivative that acts as an...

Human Interferon-inducible T cells chemoattractant (I-TAC) is a novel non-ELR CXC chemokine. ’s human I-TAC is a 8.3 kDa protein, containing 73 amino acid residues including the four highly...

IACS-010759 is a potent and selective Oxidative Phosphorylation Inhibitor (IC₅₀ < 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in...

Iberdomide is a celebron modulator that displays an IC₅₀ of 60 nM in TR-FRET cereblon binding assay. Cereblon is a substrate receptor in the CRL4 ubiquitin ligase complex. Iberdomide is potentially...

Iberin is a natural isothiocyanate from cruciferous plants. It is a hydrolysis product of glucosinolate. It induces the expression of phase II detoxification enzymes, quinone reductase (QR) and...

Cell-permeable. A nonspecific phosphodiesterase inhibitor (IC₅₀ values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively).IBMX is a nonspecific phosphodiesterase inhibitor...

Ibudilast is a phosphodiesterase inhibitorIbudilast is a phosphodiesterase inhibitorB1327 | Ibudilast DataSheetAlternate Name/Synonyms:...

Ibutamoren is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue. It mimicks the growth hormone (GH)-stimulating...

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = ~1 µM for CK1δ and CK1ɛ and 16 µM for CK1α). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn...

Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110δ (IC₅₀ = 60 nM). Inhibits p110α and p110β only at higher concentrations (>1 µM). IC87114 does not inhibit...

3422R | ICAM-1 Antibody DataSheet

3422RBP | ICAM-1 Blocking Peptide DataSheetAntibody Target: ICAM-1Accession #: BAF84666Gene ID: 25464Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

K7161 | ICAM-1 human Elisa Kit DataSheet

K7162 | ICAM-1 mouse Elisa Kit DataSheet

K7163 | ICAM-1 rat Elisa Kit DataSheet

ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human...

3926BP | ICAM-2 Blocking Peptide DataSheetAntibody Target: ICAM-2 Accession #: P35330Gene ID: 15896Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

ICAM-3/CD50, also known as CD50 (Cluster of Differentiation 50), is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain...

ICAM2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the...

Icariin is the active component of the Chinese medicinal plant E. brevicornum that acts as an inhibitor of human phosphodiesterase 5 (PDE5) (IC₅₀ = 5.9 μM). Icariin also promotes the growth and...

Icatibant acetate is a potent and specific synthetic peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively. It inhibits bradykinin-induced contractions...

A specific inhibitor of Wnt/β-catenin signaling pathway. It down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein (CBP). ICG-001...

A1081 | ICOS / CD278 Antibody DataSheet

K4247 | ICOS ligand Mouse Elisa Kit DataSheet

Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors...

Icotininb is a potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC₅₀ of 5 nM. It blocks EGFR-mediated intracellular tyrosine phosphorylation IC₅₀ of 45 nM in the...

ICR-1 is a red fluorescent calcium (Ca2+) indicator for intracellular Ca2+ measurements. It provides deeper tissue penetration and dramatic background reduction in tissues that have high...

iCRT14 is a potent potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC₅₀ = 40.3 nM). It inhibits the interaction between...

ID-8 is a cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells in vitro. At 10 μM it stimulates proliferation in serum-free media at a steady rate for...

Cell-permeable. Directs differentiation of embryonic stem cells (ESCs) into the endodermal lineage (EC₅₀ = 125 nM). Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-β-signaling...

A benzoquinone analog of coenzyme Q10 that serves as a cofactor in the electron transport chain in mitochondria. Idebenone acts as a potent lipid antioxidant that prevents the generation of free...

IDF-11774 is a potent hypoxia-inducible factor (HIF)-1 inhibitor (IC₅₀ = 3.65 μM)IDF-11774 is a potent hypoxia-inducible factor (HIF)-1 inhibitor (IC₅₀ = 3.65 μM)B2436 | IDF-11774 DataSheetAlternate...

K493 | IDH1 R132H Mutant Inhibitor Screening Kit Colorimetric DataSheet

IDO pathway inhibitor is a methylated tryptophan with anti-immunosuppressive activity. 1-Methyl-D-tryptophan inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino...

IDO-IN-2 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 0.068 µM).IDO-IN-2 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 0.068 µM).B2496 | IDO-IN-2...

IDO1 Inhibitor I is a potent IDO1 inhibitor that displays IC₅₀ values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively. It is inactive against tryptophan...

IDO1 is an indoleamine 2,3-dioxygenase - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan...

5595 | IFN alpha 2b Antibody DataSheet

5595R | IFN alpha Antibody DataSheet

5116 | IFN gamma Antibody DataSheet

IFN- is a type I interferon, which can be induced by virus-infected leukocytes. Members of the type I interferon family, which includes IFN-, IFN-, and IFN-, signal through IFNAR-1/IFNAR-2 receptor...

IFN -1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an...

IFN -1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an...

IFN-1 is a lymphoid factor that possesses potent anti-viral activity. Human IFN- is a 19.3 kDa protein containing 166 amino acid residues.4596 | IFN-alpha 1 human recombinant...

6681 | IFN-alpha 2a Antibody DataSheet

Recombinant human IFN- 2a is a single, non-glycosylated, polypeptide chain with a molecular mass 19.4 kDa containing 166 amino acid residues.4594 | IFN-alpha 2a human recombinant...

IFN- 2b is a lymphoid factor that possesses potent anti-viral activity. Human IFN- 2b is a 19.3 kDa protein containing 165 amino acid residues.4595 | IFN-alpha 2b human recombinant...

Recombinant Human IFN- 1b produced from E.Coli is a single, non-glycosylated human Interferon- 1b polypeptide chain containing 165 amino acids and having a molecular mass of 18.51 kDa. The...

E4593 | IFN-gamma Mouse Elisa Kit DataSheet

IFN- is a lymphoid factor that possesses potent anti-viral activity. It has also been shown that INF-g stimulates microphages and NK cells. Recombinant human IFN- is a 16.9 kDa protein containing 144...

IFN- is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN- receptors are present in most immune cells, which respond to IFN- signaling by increasing...

IFN- is a lymphoid factor that possesses potent anti-viral activity. It has also been shown to stimulate macrophages and NK cells. Rat IFN-is a 15.6 kDa protein containing 135 amino acid residues...

IFN-γ human Elisa Kit | K4773

IFNE (Human) ELISA Kit | E5061-100Description: Interferon epsilon (IFNE) is type I interferon which stands out through its unusual expression profile and differing regulation compared to classic type...

Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. Like...

iFSP1 inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. iFSP1 (3 μM) sensitizes a variety of human cancer cell lines to the ferroptosis inducer...

A 10% solution of the nonionic surfactant IGEPAL® CA-630 in water. Specially processed to remove the aldehydes and peroxides. Lacks the UV absorbance that causes interference in spectophotometric...

IGF-1 human Elisa Kit | K4775

5717 | IGF-BP1 Antibody DataSheet

Human IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, decidual, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after...

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and...

5720 | IGF-BP3 Antibody DataSheet

Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In...

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis,...

5723 | IGF-BP5 Antibody DataSheet

Human IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by Vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of...

IGFBP6 contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth...

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and...

5119 | IGF-I Antibody DataSheet

Human IGF-1 (insulin-like Growth Factor-1, IGF1, MGF, Somatomedin) is a hormone similar in molecular structure to insulin. It is a polypeptide growth factor that stimulates the proliferation of a...

IGF-I (insulin-like Growth Factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Murine IGF-I is a 7.6...

IGF-I (insulin-like Growth Factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Rat IGF-I is a 7.69...

5122 | IGF-II Antibody DataSheet

IGF-II (insulin-like Growth Factor-II) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types. Human IGF-II is a 7.5 kDa protein containing 67 amino acid...

7020 | IGFBP5 Antibody DataSheet

IITZ-01 is a potent potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine (Cat. No.1825); enhances autophagosome accumulation but inhibits...

3315 | IkBalpha Antibody (Clone 6A055) DataSheet

3252 | IkBalpha Antibody DataSheet

A benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC₅₀ = 40 nM); displays >125-fold selectivity over IKK-α and IKK-β.IKK-ε Kinase Inhibitor II is a benzimidazole...

IKK-16 is a potent and selective inhibitor of IκB kinase (IKK) with IC₅₀ values from 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. It is effective in cells and in animals and has...

3185 | IKKalpha/IKK-1 Antibody DataSheet

5125 | IL-1 alpha Antibody DataSheet

IL-1 is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses. ’s Human IL-1 is an 18.0 kDa protein containing 159 amino acid residues.4125 | IL-1 alpha human...

Recombinant mouse Interleukin-1 alpha (IL-1α) produced in E. coli is a non-glycosylated polypeptide chain containing 156 amino acids and has a molecular weight of 18 kDa. Murine IL-1α is a potent...

Interleukin-1 (IL-1 is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses. Rat IL-1 is a 17.7 kDa protein containing 155 amino acid residues.4127 | IL-1 alpha...

5128 | IL-1 beta Antibody DataSheet

IL-1 is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses including the activation of B and T cells. Recombinant human IL-1 is a 17.0 kDa protein containing...

IL-1 is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 and IL-1 binds to the same receptor and...

IL-1 is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 and IL-1 binds to the same receptor and...

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of...

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of...

6638 | IL-10 Antibody DataSheet

K4167 | IL-10 Human Elisa Kit DataSheet

IL-10 (Interleukin-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF), is an 18.6 kDa protein containing 161 amino acid residues. It shares over 80% sequence homology with the...

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of...