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PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 displays more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. PF-04217903...

PF-04418948 is a potent EP2 receptor antagonist with an IC₅₀ of 16 nM for human EP2 receptors. It also displays greater selectivity for EP2 receptors over EP1, 3, 4, DPI and CRTH2 receptors. It...

PF-04447943 is a potent, brain-penetrant and selective inhibitor of PDE9 (Phosphodiesterase 9) (Ki of 2.8, 4.5 and 18 nM for human, rhesus and rat recombinant PDE9 respectively). Displays high...

PF-04449913 is a potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC₅₀ of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and...

PF-04554878 is potent, ATP-competitive, focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. PF-04554878 inhibits FAK phosphorylation at the Tyr397 site...

PF-04620110 is a potent and selective Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) inhibitor with (IC₅₀ = 19 nM).PF-04620110 is a potent and selective Acyl-CoA:diacylglycerol acyltransferase-1...

A potent, ATP-competitive PI3K/mTOR dual inhibitor with broad antitumor activity. PF-04691502 potently inhibits recombinant class I PI3K and mTOR in biochemical assays and suppresses transformation...

PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112). It binds both Hsp90α and Hsp90β with an IC50 value of 30 nM. PF-04929113, is rapidly absorbed and converted into the active...

PF-04965842 (Abrocitinib) is a potent, selective, orally bioavailable JAK1 inhibitor (IC₅₀ = 29 nM). It displays excellent selectivity for JAK1 versus other JAK family enzymes.PF-04965842...

Potent and selective inhibitor of CYP3A (IC50 = 30 nM (CYP3A4), 17 μM (CYP3A5) and 70 μM (CYP3A7).Potent and selective inhibitor of CYP3A (IC50 = 30 nM (CYP3A4), 17 μM (CYP3A5) and 70 μM (CYP3A7)...

PF-05212384 is a potent, selective and ATP-competitive dual inhibitor of PI 3-kinase/mTOR (IC₅₀ values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over...

PF-06291874 is a glucagon receptor antagonist potentially useful for patients with type 2 diabetes mellitus.PF-06291874 is a glucagon receptor antagonist potentially useful for patients with type 2...

PF-06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Displays minimal off-target effects on a panel of...

PF-06447475 is a highly potent, selective, brain-permeable, and in vivo active LRRK2 (Leucine rich repeat kinase 2) kinase inhibitor. Could be potentially useful in the treatment of Parkinson’s...

PF-06463922 is a potent, selective, brain-penetrant, and high affinity ALK (Anaplastic lymphoma kinase) and ROS1 (c-Ros oncogene 1) inhibitor displaying >100-fold selectivity for ROS1 over panel of...

PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4).PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4).B1558 | PF-06650833...

PF-06821497 is a potent and selective EZH2 (Enhancer of Zeste Homolog 2) inhibitor, inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM). Displays robust tumor...

PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 μM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced...

PF-3084014 (Nirogacestat) is a potent and selective gamma-secretase inhibitor (IC₅₀ of 6.2 nM). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.PF-3084014 (Nirogacestat) is a potent and...

PF-3274167 is a potent, selective, and high-affinity non-peptide oxytocin receptor (OTR) antagonist (Ki of 9.5 nM).PF-3274167 is a potent, selective, and high-affinity non-peptide oxytocin receptor...

PF-3716556 is a selective H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Highly selective for H+,K+-ATPase in vitro; inhibits gastric acid secretion, displays no activity...

PF-3758309 is a potent small molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth...

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the -granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis...

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor with IC₅₀ values 2 and 11 nM respectively.PF-431396 is dual focal adhesion kinase (FAK) and...

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with a Ki of 20 nM and IC₅₀ of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in...

PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest...

PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits PI3Kalpha (Ki=0.6 nM) and mTOR (Ki=1440 nM).PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216...

F-562271 is an ATP-competitive, reversible inhibitor of FAK (IC₅₀ = 1.5 nM). It displays 10-fold reduced potency for PYK2 (IC₅₀ = 14 nM) and >100-fold selectivity against other protein kinases...

PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC₅₀ = 4 nM). PF-573,228 inhibits FAK phosphorylation on Tyr(397) with an IC₅₀ of 30-100 nM. Displays 50 - 250-fold...

PF-670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other kinases. Inhibits PER...

PF-8380 is a potent and specific inhibitor of Autotaxin (ATX) (IC₅₀ = 2.8 nM). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin. Autotaxin (ATX) is a...

PF-9366 is an allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform (IC₅₀ = 420 nM). PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production...

PF299804 (Dacomitinib) is a potent, irreversible pan-HER inhibitor with IC₅₀’s of 6, 46, and 74 nM for ErbB1(HER1), ErbB2 (HER2), and ErbB4 (HER4), respectively. PF299804 inhibits ErbB1...

PF74 is a HIV-1 inhibitor that targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells. PF74 acts at an early stage of HIV-1...

PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC₅₀...

PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor (IC₅₀ ~2 nM). It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets...

PFI-3 is a potent and selective polybromo 1 (PB1) and SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) inhibitor (Kd values are 48 and 89 nM...

PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Displays >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. BRPF1...

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC₅₀ = 137 nM for human recombinant PFKFB3). Upon administration, PFK-158 binds to and inhibits the activity...

’s Pfu DNA Polymerase, combined with optimized buffer for high-fidelity and yield, provides the most accurate and consistent performance in PCR. ’s enzyme demonstrates up to 20 folds greater accuracy...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

3934BP | PGC-1 alpha Blocking Peptide DataSheetAntibody Target: PGC-1 alphaAccession #: NP_032930.1Gene ID: 19017Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

3934 | PGC-1alpha Antibody DataSheet

Phosphoglycerate kinase 1 (PGK1) is an X-linked enzyme that plays a key role in the glycolytic pathway. The gene encoding the erythrocyte enzyme PGK1 and it seems that PGK-1 acts as a polymerase...

PGK2 is a testis-specific form of phosphoglycerate kinase. Initially assumed to be a pseudogene, this protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion...

Phosphoglycolate phosphatase, also known as PGP, is detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The catalytic activity of PGP is...

PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β.PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective...

PHA-665752 is a potent, selective and ATP-competitive inhibitor of MET kinase (IC₅₀ values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively...

PHA-680632 is potent inhibitor of Aurora kinases A, B, and C with IC₅₀ values of of 27 nM, 135 nM and 120 nM, respectively. It displays weaker selectivity for FGFR1, FLT3, LCK, PLK1, STLK2, and...

PHA-767491 is a potent and selective ATP-competitive dual cdc7/cdk9 inhibitor.PHA-767491 is a potent and selective ATP-competitive dual cdc7/cdk9 inhibitor.B1639 | PHA-767491(HCl) DataSheetAlternate...

6858 | PHC2 polyclonal antibody DataSheet

An anti-diabetic drug of the biguanide class. Increases AMPK activity without increasing AMP/ATP. Also acts as a mitochondrial complex I inhibitor.Phenformin hydrochloride is an anti-diabetic drug of...

K527 | Phenolic Compounds Assay Kit Colorimetric DataSheet

K481 | Phenylalanine Assay Kit Colorimetric DataSheet

K572 | Phenylalanine Fluorometric Assay Kit DataSheet

6850 | PHF8 polyclonal antibody DataSheet

Phi29 DNA Polymerase is a highly processive polymerase which exhibits a strong strand-displacement function. M1239 | Phi29 DNA Polymerase DataSheetSort Name: Phi29 DNA PolymeraseLabel Name: Phi29 DNA...

PhiKan083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. PhiKan083 slows rate of thermal...

Phleomycin is an antibiotic produced by Streptomyces verticullus and is structurally related to Bleomycin. Used as a selective agent in transformation experiments with mammalian cells, plant cells...

Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC₅₀ = 28 and 14 µM, respectively), restricting the rapid transport...

Phlorizin is a competitive inhibitor of SGLT1 (sodium glucose co-transporter 1) and SGLT2 (sodium glucose co-transporter 2); this reduces renal glucose transport, lowering the amount of glucose in...

This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter...

K420 | Phosphate Assay Kit Fluorometric DataSheet

10 X concentrate of PBS, which can be used for cell culture.2113 | Phosphate Buffered Saline (PBS) DataSheetSort Name: Phosphate Buffered Saline (PBS)Label Name: N/ATaglines: 1 X PBSProduct...

K410 | Phosphate Colorimetric Assay Kit DataSheet

K576 | Phosphatidylcholine Colorimetric/Fluorometric Assay Kit DataSheet

K499 | Phosphatidylethanolamine Assay Kit Fluorometric DataSheet

K488 | Phosphatidylglycerol Assay Kit Fluorometric DataSheet

K565 | Phosphatidylserine Assay Kit Fluorometric DataSheet

A1219 | Phospho Alpha-synuclein (Tyr125) Antibody DataSheet

A1222 | Phospho CREB (Ser129) Antibody DataSheet

A1220 | Phospho GAP43 (Ser41) Antibody DataSheet

3612 | Phospho (Ser19) Tyrosine Hydroxylase Antibody DataSheet

3613 | Phospho (Ser31) Tyrosine Hydroxylase Antibody DataSheet

Phospho Tyr1472 NMDA NR2B Antibody | 3616

3257 | Phospho-Akt Antibody DataSheet

Phospho-Akt Ser473 Elisa Kit | K4211

A1245 | Phospho-Akt1 (Ser246) Antibody DataSheet

A1041 | Phospho-AKT1 (Ser473) Polyclonal Antibody DataSheet

A1036 | Phospho-AKT1 (Tyr474) polyconal Antibody DataSheet

A1246 | Phospho-Akt2 (Ser474) Antibody DataSheet

A1044 | Phospho-ALIX polyconal Antibody DataSheet

A1714 | Phospho-ALOX5 (Ser523) Antibody DataSheet

A1248 | Phospho-AMPK?1 (Ser182) Antibody DataSheet

A1247 | Phospho-AMPK?1 (Ser496) Antibody DataSheet

A1156 | Phospho-ANAPC1 (Ser688) Antibody DataSheet

A1249 | Phospho-AP-1 (Ser63) Antibody DataSheet

A1251 | Phospho-ASK 1 (Ser83) Antibody DataSheet

A1241 | Phospho-ASK1 (Ser83) Antibody DataSheet