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Pimobendan is a calcium sensitizer and a selective inhibitor of phosphodiesterase III (PDE3) with positive inotropic and vasodilator effects. Pimobendan has been studied for treating heart failure...

Cell-permeable. An antipsychotic drug and D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor. A Stat5 inhibitor; decreases Stat5 tyrosine phosphorylation, but does...

Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM,...

3929BP | PINK1 Blocking Peptide DataSheetAntibody Target: PINK1 Accession #: EDL13261Gene ID: 68943Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of...

Cell-permeable. A thiazolidinedione (TZD) derivative that acts as a selective peroxisome proliferator-activated receptor gamma (PPARγ) agonist (EC₅₀ = 0.69 μM). An antidiabetic agent; improves...

Piperine is the primary pungent alkaloid isolated from the fruit of black peppercorns. It displays a variety of therapeutic activities such as anti-oxidant, anti-inflammatory, immunomodulatory,...

A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in...

Piperlonguminine is a known alkaloid amide from peppers, including Piper divaricatum. Acts as a potent anticancer agent. Displays inhibitory effect on alpha-melanocyte-stimulating hormone...

Pirarubicin is an analog of doxorubicin, that acts as an antineoplastic drug. Pirarubicin is transported into cells via a sodium-dependent nucleoside transporter. It is used to intercalate DNA and...

Pirfenidone is a small molecule antifibrotic agent. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines...

Pitavastatin calcium is a synthetic inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase, (Ki = 1.7 nM). It lowers both total cholesterol and low density lipoprotein (LDL)...

An analog of Mitoxantrone (Cat. No. 1885-50, 250) that displays antitumor properties with fewer toxic effects on cardiac tissue. Acts as a topoisomerase II poison and intercalating agent.Pixantrone...

A potent, water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC₅₀ = 20 nM). Inhibits peroxynitrite-induced cell necrosis and displays significant, dose-dependent anti-inflammatory effects in...

Cell-permeable. A Selective peripheral benzodiazepine antagonist. Enhances apoptosis and induces mitochondria cytochrome c release. Inhibits insulin secretion induced by glucose. Also displays...

3115 | PKA Antibody DataSheet

3115BP | PKA Blocking Peptide DataSheetAntibody Target: PKAAccession #: P05132 Gene ID: 18747Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

PKA C- (PKAcg) is a third isoform of the catalytic subunit of cAMP-dependent protein kinase. It was isolated from a human testis cDNA library and was clearly derived from a gene distinct from C- and...

Most of the effects of cAMP are mediated through the phosphorylation of target proteins on serine or threonine residues by the cAMP-dependent protein kinase (AMPK). The inactive holoenzyme of AMPK is...

Most of the effects of cAMP are mediated through the phosphorylation of target proteins on serine or threonine residues by the cAMP-dependent protein kinase (PKA). The inactive holoenzyme of AMPK is...

3450 | PKC Antibody DataSheet

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide...

3450BP | PKC Blocking Peptide DataSheetAntibody Target: PKCAccession #: EDL17279.1Gene ID: 18751Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Protein kinase C delta (PKC delta) is a member of the protein kinase C (PKC) family of serine-threonine kinases. It is a 79 kd protein kinase that shows strict dependence on the presence of...

PKC is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse...

PKC is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKC showed greatest homology to PKC zeta, with 72% identity overall rising to 84% in the...

Cell-permeable. A derivative of Staurosporine (Cat. No. 1048) that inhibits a variety of serine/threonine and tyrosine kinases including protein kinase C (PKC) IC₅₀ = 50 nM), cyclic AMP-dependent...

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide...

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide...

PKC eta is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse...

Protein kinase Cmu (PKCmu) is a novel member of the protein kinase C (PKC) family that differs from the other isoenzymes in structural and enzymatic properties. It is characterized by the presence of...

PKCnu, also known as PKD3, is a members of the protein kinase C (PKC) family of serine/threonine kinases that play critical roles in the regulation of cellular differentiation and proliferation in...

PKC (PKC zeta) is an atypical isoform of the PKC family. PKC is found in both particulate and soluble fractions and cannot be activated by phorbol ester. Treatment of cells with phorbol ester which...

PKD2 is a novel phorbol ester- and growth factor-stimulated serine/threonine kinase that contains two cysteine-rich motifs at the N terminus, a pleckstrin homology domain, and a catalytic domain (1)...

PKF118-310 | B3373Description: PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. It disrupts binding of β-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM). ...

3452 | PKG Antibody DataSheet

3452BP | PKG Blocking Peptide DataSheetAntibody Target: PKG Accession #: ABQ59040Gene ID: 5592Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

PKI-402 is a reversible, potent dual inhibitor of PI3K/mTOR with IC50 values of 2 nM/7 nM/16 nM/14 nM and 3 nM for PI3Kα/β/γ/δ and mTOR, respectively.PKI-402 is a reversible, potent dual inhibitor of...

PKI-402 is a potent dual inhibitor of PI3K/mTOR with IC50 values of 2 nM/7 nM/16 nM/14 nM and 3 nM for PI3Kα/β/γ/δ and mTOR, respectively. PKI-402 is a potent dual inhibitor of PI3K/mTOR with IC50...

PKM2 inhibitor is a potent pyruvate kinase M2 (PKM2) inhibitor (IC₅₀ = 2.95 μM).PKM2 inhibitor is a potent pyruvate kinase M2 (PKM2) inhibitor (IC₅₀ = 2.95 μM).B2593 | PKM2 Inhibitor...

5869 | Placental Lactogen Antibody DataSheet

Placental Lactogen is a polypeptide hormone that is produced by the Syncytiotrophoblasts of the Placenta, also known as chorionic somatomammotropin. It has both Growth Hormone and Prolactin...

Human placental lactogen (HPL), also called human chorionic somatomammotropin, is a polypeptide placental hormone. Its structure and function is similar to that of growth hormone. It modifies the...

Plant Advance Pcr Kit | M1144

K296 | Plant Tissue Extraction Kit DataSheet

K316 | Plant Tissue Genomic DNA Isolation Kit DataSheet

K997 | Plasma Kallikrein Activity Assay Kit Colorimetric DataSheet

K989 | Plasma Kallikrein Inhibitor Screening Kit Colorimetric DataSheet

K1445 | Plasmid DNA extraction and purification kit DataSheet

K1319 | Plasmid ezFilter Maxi Kit DataSheet

K1322 | Plasmid ezFilter Mega10 Kit DataSheet

K1320 | Plasmid ezFilter Mega3 Kit DataSheet

K1321 | Plasmid ezFilter Mega6 Kit DataSheet

K1316 | Plasmid ezFilter Midi Kit I Centrifuge DataSheet

K1317 | Plasmid ezFilter Midi Kit II Centrifuge DataSheet

K1314 | Plasmid Midi Kit I DataSheet

K1315 | Plasmid Midi Kit II DataSheet

K529 | Plasmid Miniprep Kit DataSheet

K1312 | Plasmid Miniprep Kit I DataSheet

K1313 | Plasmid Miniprep Kit II DataSheet

K381 | Plasmin Activity Assay Kit Fluorometric DataSheet

6964 | Plasmin Antibody DataSheet

K382 | Plasmin Inhibitor Screening Kit Fluorometric DataSheet

Plasmin is a serine protease which cleaves polypeptide chains after arginyl and Iysyl residues. In addition to cleavage of fibrin, plasmin also catalyzes activation and/or degradation of compounds of...

A chromogenic plasmin substrate. Plasmin cleaves p-nitroanilide (pNA) releasing p-nitroanilne that can be quantified using a spectrophotometer or a microtiter plate reader at ~ 405 nm.Plasmin...

Plasmin functions in fibrinolysis, fibrinogenolysis, as well as in the complement cascade. This protease has been prepared by using streptokinase to activate human plasma plasminogen.4089 | Plasmin...

7014 | Plasminogen Antibody DataSheet

E4641 | Plasminogen PLG Human Elisa Kit DataSheet

E4642 | Plasminogen PLG Rat Elisa Kit DataSheet

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation...

E4631 | Platelet Activating Factor PAF Elisa Kit DataSheet

3587 | PLC gamma 2 Antibody DataSheet

3587RBP | PLC gamma 2 Blocking Peptide DataSheetAntibody Target: PLC gamma 2 Accession #: P16885Gene ID: 5336Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in...

3710BP | PLC gamma Blocking Peptide DataSheetAntibody Target: PLC gamma Accession #: AAH18646Gene ID: 5336Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Human Pleiotrophin (PTN) also called HARP (Heparin affin regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN (Pleiotrophin) and MK (midkine) are structural...

Plerixafor is a hematopoietic stem cell (HSC) mobilizer. It is used to stimulate the release of stem cells from the bone marrow into the blood in patients with non-Hodgkin lymphoma and multiple...

5743 | PlGF Antibody DataSheet

PLGF (also called Placenta Growth Factor, PIGF, PGF) is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PLGF is expressed in placental tissues, colon and mammary...

5739 | PlGF-1 Antibody DataSheet

PLGF (also called Placenta Growth Factor, PIGF, PGF) is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PLGF is expressed in placental tissues, colon and mammary...

PLGF-2 is produced in E. coli as a homodimer containing 2 x 153 amino acids and having a total molecular mass of 36 kDa.4741 | PLGF-2 human recombinant DataSheetBiomolecule/Target: N/ASynonyms:...

PlGF-3 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PlGF-3 is expressed exclusively in the placenta. It signals through the VEGFR-1/FLT1 receptor, and...

Plinabulin (NPI-2358) is a vascular disrupting agent (VDA). Plinabulin binds to the colchicine binding site of β-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network...

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) (IC50 = 2.6 µM). PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM.PLpro inhibitor is a...

K593 | PLTP Activity Fluorometric Assay Kit II DataSheet

3595 | PLTP Antibody DataSheet

3595BP | PLTP Blocking Peptide DataSheetAntibody Target: PLTP Accession #: P55058Gene ID: 5360Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties...

Pluripotin (SC1) regulates mouse embryonic stem cell (ESC) self-renewal. It was shown that SC1 is sufficient for sustaining long-term self-renewal of mouse ES cells in an undifferentiated state in...

A selective inhibitor of steroyl-CoA desaturase 1 (SCD1), the key enzyme in oleic acid biosynthesis. PluriSIn 1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs (human...

Pluronic® F-127 is a non-ionic detergent useful for isolation of membrane proteins. It has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological...

Pluronic® F-127 is a non-ionic detergent useful for isolation of membrane proteins. It has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological...

PLX3397 is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. PLX3397 binds to and inhibits phosphorylation of stem cell factor...

Cell-permeable. A potent, selective and ATP-competitive, inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. PLX-40432 selectively binds to the ATP-binding site of BRAF(V600E)...

PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC₅₀ =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent...

PLX-51107 is a potent inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon administration, PLX51107 binds to the acetylated lysine recognition motifs...

PLX7904 is a potent and selective paradox-breaker RAF inhibitor. PLX7904 efficiently inhibits activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant...

PLX5622 is an inhibitor of colony-stimulating factor 1 receptor (CSF1R) tyrosine kinase with a Ki of 5.9 nM. It causes sustained and specific elimination of microglia. As a result of microglial...

PM20D1 Activity Assay Kit (Colorimetric) | K2107-100Description: Peptidase M20 domain containing 1 (PM20D1), also known as N-fatty-acyl-amino acid synthase/hydrolase, is a secreted enzyme that...

3455BP | PMS2 Blocking Peptide DataSheetAntibody Target: PMS2 Accession #: P54278Gene ID: 5395Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.5 mg/ml) in PBS, pH 7.2, 30%...