MMP14 Antibody| F40218-0.08ML/F40218-0.4ML/R31266

MMP14 Antibody| F40218-0.08ML/F40218-0.4ML/R31266 | Gentaur UK, US & Europe Distribution

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Format: Purified

Clone: 133CT15.10.5.1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgM

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Bovine, Pig, Rabbit

Application: WB, IF, ELISA

Application Details: Western blot: 1:100-1:1000, Immunofluorescence: 1:10-1:50

Application Note: Titration of the MMP14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This MMP14 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 470-499 from the human protein was used as the immunogen for this MMP14 antibody.

Storage: Aliquot the MMP14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A