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Elbasvir is a potent inhibitor of Hepatitis C virus (HCV), non-structural protein 5A (NS5A). It is active against many HCV genotypes with EC₅₀ values in the picomolar range (0.0003 nM-3.4 nM). It is...

Elcatonin is a Calcitonin derivative which is transformed from eel´s calcitonin by changing the S-S bond into the stable C-N bond. It inhibits the absorption and autolysis of bones, thus leads to...

Elesclomol is a novel anticancer agent that displays oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. The mechanism underlying the proapoptotic activity of...

Elevenostat (JB3-22), is a small molecule hydroxamic acid derivative that acts as a HDAC11-selective inhibitor. Reporter assays using a luciferase-linked Foxp3 promoter shows that HDAC11 decreases...

Eliglustat is a potent and specific inhibitor of glucosylceramide synthase. Eliglustat is a new promising substrate reduction therapy (SRT) for Gaucher disease (GD). Eliglustat works by inhibiting...

3387 | Elk-1 Ab DataSheet

Ellagic acid is a potent anti-oxidant that displays anti-cancer and anti-mutagenic properties. It inhibits CK2 (casein kinase 2) selectively with IC₅₀ values of 40 nM. It moderately inhibits...

Ellipticine is a naturally occurring plant alkaloid that acts as a DNA intercalating agent and DNA topoisomerase II inhibitor. Ellipticine is also shown to block p53 protein phosphorylation...

ELR-510444 is a potent microtube disruptor with potential anticancer activity. It displays potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of...

Eltoprazine is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Kis = 40, 52, and 81 nM, respectively). Reduces 5-HIAA levels in the striatum and displays antiaggressive behavior...

Eltrombopag is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet...

Elvitegravir is a novel HIV-1 integrase inhibitor that blocks strand transfer by the viral enzyme. It displays an IC₅₀ of 7.2 nM in the strand transfer assay, and shows an EC₅₀ of 0.9 nM in an acute...

Endothelial-Monocyte Activating Polypeptide-II (EMAP-II) is a tumor derived cytokine that is an anti-angiogenic factor in tumor Vascular development, and strongly inhibits tumor growth. Recombinant...

A synthetic peptide that irreversibly inhibits EMAP II (Endothelial Monocyte-Activated Polypeptide II) activity released during apoptosis. The inhibitor is designed as a methyl ester to facilitate...

Emavusertib | B3378Description: Emavusertib is an orally bioavailable, reversible inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4), with potential antineoplastic, immunomodulating and...

An inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein)An inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein)B1600 | Embelin DataSheetAlternate Name/Synonyms:...

EMD-1214063 | B1297

Emeramide, also known as BDTH2, is a mercury chelator and an antioxidant, for the treatment of mercury poisoning. The molecule consists of two thiol groups and linked via a pair of amide groups...

An alkaloid derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA...

A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome...

EML-425 is a potent, reversible and non-competitive dual CBP and p300 inhibitor (IC₅₀ values are 1.1 and 2.9 μM, respectively). EML425 induced a marked and time-dependent reduction in the acetylation...

Cell-permeable. A naturally occurring anthraquinone that displays a range of biological activities including anti-inflammatory, anti-tumor and neuroprotective effects. Acts as a potent p56lck...

3923 | EMP-3 Antibody DataSheet

3923BP | EMP-3 Blocking Peptide DataSheetAntibody Target: EMP-3 Accession #: NP_001416Gene ID: 2014Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Empagliflozin is a potent and selective SGLT-2 (sodium glucose co-transporter-2) inhibitor (IC₅₀ of 3.1 nM); displays >300-fold selectivity over SGLT-1, 4, 5 and 6. Antidiabetic agent.Empagliflozin...

3652 | EMR2 Antibody DataSheet

3652BP | EMR2 Blocking Peptide DataSheetAntibody Target: EMR2Accession #: A0JNV7Gene ID: 30817Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

Emricasan (PF-03491390) is an irreversible pan-caspase inhibitor. In a mouse model of α-Fas-induced acute liver injury, the orally-administered caspase inhibitor Emricasan was retained in the liver...

Emtricitabine is a cytidine analog that acts as an inhibitor of reverse transcriptase, preventing replication of HIV-1 (EC50 = 10-20 nM) and hepatitis B (EC50 = 10-40 nM). It is activated through...

ENA-78 (Epithelial Neutrophil Activating Peptide-78) is a recently discovered chemoattractant and activator for neutrophils, belonging to the IL-8 subgroup of the C-X-C family of chemokines. The...

Enalapril is a potent angiotensin converting-Enzyme (ACE) inhibitor used to treat for hypertension and heart failure. As a prodrug, enalapril is converted by de-esterification into its active form...

Encorafenib (LGX818) is a potent mutated BRafV600E inhibitor (IC₅₀ = 0.3 nM) with potential antineoplastic activity. Displays little activity against wild-type B-Raf or a panel of 100 other kinases...

3336R | EndoG Antibody DataSheet

3336RBP | EndoG Blocking Peptide DataSheetAntibody Target: EndoG Accession #: NP_001030110.1Gene ID: 362100Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found...

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found...

5799 | Endostatin Antibody DataSheet

Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin...

Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin...

3657 | Endothelial Lipase Antibody DataSheet

3657BP | Endothelial Lipase Blocking Peptide DataSheetAntibody Target: Endothelial LipaseAccession #: Q9Y5X9Gene ID: 9388Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5...

K536 | Endothelin Converting Enzyme 1 Activity Assay Kit Fluorometric DataSheet

K7429 | Endothelin-1 Elisa Kit DataSheet

Endoxifen is the metabolite of Tamoxifen (Cat. No.1551) and Estrogen receptor α (ERα) ligand. Endoxifen is responsible for the effectiveness of tamoxifen in ER-positive breast cancer. Potent...

Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS. It binds to the first heptad-repeat (HR1) in the gp41 subunit of the viral envelope glycoprotein and...

K130 | Enhanced Apoptotic DNA Ladder Detection Kit DataSheet

The recombinant EGFP is expressed and purified from transformed E. coli using a method that ensures high purity and maximal GFP fluorescence. Endotoxin has been removed, so the protein is suitable...

ENMD-2076 is a selective inhibitor of Aurora A and Flt3 with IC₅₀ values of 14 and 1.86 nM, respectively. Displays 5-fold selectivity for Aurora A than over Aurora B and less potent to VEGFR2/KDR and...

K691 | Enolase Activity Colorimetric/Fluorometric Assay Kit DataSheet

3426R | eNOS Antibody DataSheet

Antibody Target: eNOS Accession #: Gene ID: Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1%...

E4277 | Enrofloxacin ENR Elisa Kit DataSheet

Enrofloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase. Enrofloxacin displays high bioavailability in most species and rapid absorption after oral,...

Ensartinib (X-396), is a potent, small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Ensartinib has been active in animal...

Entacapone is a potent catechol O-methyl transferase (COMT) inhibitor with IC₅₀ values of 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT, respectively...

Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing...

Enterokinase (EC 3.4.21.9) is a serine protease involved in the activation of trypsinogen to trypsin, which in turn results in the activation of various digestive enzymes. It recognizes a highly...

Enteropeptidase substrate is a useful fluorogenic substrate for determining the activity of the enzyme enteropeptidase/enterokinase. This enzyme recognizes a highly specific amino acid sequence...

K758 | Enteropeptidase/Enterokinase Activity Fluorometric Assay Kit DataSheet

K760 | Enteropeptidase/Enterokinase Cleavage Kit DataSheet

K759 | Enteropeptidase/Enterokinase Inhibitor Screening Kit Fluorometric DataSheet

Entrectinib is an inhibitor of TrkA (IC₅₀ = 1.7 nM), TrkB (IC₅₀ = 0.1 nM), and TrkC (IC₅₀ = 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC₅₀ = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC₅₀ = 1.6...

Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM). Enz suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases...

Eosinophil Peroxidase Human Eosinophils | 4103

Eotaxin-2 also known as MPIF-2 is a CC chemokine characterized by its high chemotactic selectivity for eosinophils. ’s human eotaxin-2 is 8.8 kDa protein containing 78 amino acid residues.4497 |...

Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including...

Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including...

5029 | Eotaxin/CCL11 Antibody DataSheet

Eotaxin is a recently discovered chemokine characterized by its high chemotactic selectivity for eosinophils. The position of the four cystein residues in Eotaxin places it in the C-C family of...

Murine eotaxin shares many of the biological and physical characteristics of human eotaxin. The chemokine exhibits a high chemotactic selectivity for eosinophils and belongs to the C-C family of...

E4352 | Ep-CAM Human Elisa Kit DataSheet

Epalrestat is an aldose reductase inhibitor (IC₅₀ = 10 nM (rat lens) and 25 nM (human placenta). It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. May be used to...

Human epidermal growth factor (EGF) is also known as HOMG4 and URG, and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding...

EPGN is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. EPGN is produced in numerous tissues, including the testis, liver, heart and in certain tumor cells. EPGN is...

Epiregulin is part of the EGF family. Epiregulin functions as a ligand of EGFR, as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors...

Cell-permeable. An anthracycline antitumor antibiotic. A stereoisomer of doxorubicin (Cat. No. 1527-5) that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting...

6969 | EPO Antibody DataSheet

Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid...

Recombinant Human Erythropoietin-α produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology is a single, polypeptide chain containing 165 amino acids and having a predicted...

Recombinant Human Erythropoietin- is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology is a single, polypeptide chain containing 165 amino acids and having a predicted...

A macrolide anticancer agent. Similar to paclitaxel (Cat. No. 1567-25), epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to...

Epothilone D is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the...

Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent...

Eptapirone (also known as F11440 ), is a potent and selective 5HT1A receptor agonist showing anxiolytic and antidepressant properties.Eptapirone (also known as F11440 ), is a potent and selective...

A glycoprotein (GP) IIa/IIIb inhibitor. Eptifibatide inhibits platelet aggregation by reversibly binding to the platelet receptor glycoprotein (GP) IIb/IIIa of human platelets, thus preventing the...

EPZ015666 is a potent, selective PRMT5 inhibitor (Ki of 5 nM); displays >20,000-fold selectivity over other PMTs. EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50,...

A potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM). EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and...

A potent and selective inhibitor of histone methyltransferase EZH2. EPZ-6438 specifically inhibits cellular H3K27 methylation leading to selective apoptotic killing of SMARCB1 mutant MRT cells. It...

A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little...

EPZ011989 is a potent EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an...

EPZ015866 (GSK591) is a potent selective inhibitor of the arginine methyltransferase PRMT5/MEP50 complex thus stopping the methylation of histone H4 with IC₅₀ of 11 nM. It also maintains superior...

Estrogen receptor beta (ERβ) is a member of the family of estrogen receptors and the superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain...

ER Transcription Factor Activity Assay Kit (Colorimetric) | K2105-100Description: Estrogens including estrone, estradiol, estriol, and estretrol belong to the family of organic compounds known as...

ER-Hunt Green is a cell-permeable, live-cell stain that is selective for the endoplasmic reticulum (ER). Glibenclamide (glyburide) binds to the sulphonylurea receptors of ATP-sensitive K⁺ channels...

ER-Hunt Red is cell-permeable, live-cell stain that is selective for the endoplasmic reticulum (ER). Glibenclamide (glyburide) binds to the sulphonylurea receptors of ATP-sensitive K⁺ channels which...

3255 | ERAB/HCD2 Antibody DataSheet

3255BP | ERAB/HCD2 Blocking Peptide DataSheetAntibody Target: ERAB/HCD2Accession #: O70351Gene ID: 63864Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Erastin is a selective antitumor agent that displays greater lethality in human tumour cells harbouring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent...

ErbB4, also known as Her4, is a member of the tyrosine kinase receptors (RTK) and the epidermal growth factor receptor (EGFR) subfamily, and appears to play important roles in differentiation,...

Erdafitinib is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. It inhibits FGFR1/2/3/4 with IC₅₀s of 1.2, 2...