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NME4, also known as nucleoside diphosphate kinase, mitochondrial, belongs to the NDK family. NME4 are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine...

This is the nuclear NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as...

NMNAT2 belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human...

This is the Mitochondrial NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN)...

NMS-1286937 a potent, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC₅₀ = 2 nM) with potential antineoplastic activity. It selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest...

NMS-873 is a potent, selective, allosteric inhibitor of the ATPase VCP/p97 (IC₅₀ = 30 nM). NMS-873 activates the unfolded protein response, interferes with autophagy and induces cancer cell death...

A potent, and selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. It is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). NMS-P118 displays anticancer activity as single agent, as...

6673 | NNMT Antibody DataSheet

NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory...

A useful nitric oxide (NO) donor. NOC-18 spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to...

A microtubule inhibitor; inhibits mitosis. Disrupts microtubules by binding to β‑tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule...

Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values...

5775 | Noggin Antibody DataSheet

Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF- family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally...

K489 | Non-Alcoholic Fatty Liver Disease NAFLD Detection Kit DataSheet

NONO Antibody | 3751

Noopept is a novel proline-containing dipeptide with nootropic and cognition-enhancing activity. Rescues α-synuclein amyloid toxicity in cellular models. Stimulates the expression of NGF and BDNF in...

nor-NOHA acetate is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA. Nor-NOHA is about 40-fold more...

E4360 | Norepinephrine NE Elisa Kit DataSheet

A pharmacologically active metabolite of quetiapine. Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.Norquetiapine...

E4648 | NOS2 / iNOS Human Elisa Kit DataSheet

E4691 | NOS2 / iNOS mouse Elisa Kit DataSheet

E4649 | NOS2 / iNOS Rat Elisa Kit DataSheet

E4650 | NOS3 / eNOS Human Elisa Kit DataSheet

E4651 | NOS3 / eNOS Mouse Elisa Kit DataSheet

E4652 | NOS3 / eNOS Rat Elisa Kit DataSheet

3881 | Notch 1 Antibody DataSheet

3881BP | Notch 1 Blocking Peptide DataSheetAntibody Target: Notch 1 Accession #: NP_032740Gene ID: 18128Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Notch-1 human Elisa Kit | K4763

Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and...

Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and...

Nourseothricin is group of a broad-spectrum antibiotic produced by Streptomyces variants; inhibits protein synthesis by inducing miscoding. Streptothricin antibiotic Nourseothricin (NTC) is used for...

Novo cDNA Supermix | M1169

Novo Transcriptome cDNA Kit | M1167

Novobiocin is a coumarin antibiotic isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase. Its antibacterial activity arises from competitive inhibition of the ATPase...

NovoTM cDNA Kit contains a Moloney-Murine Leukemia Virus Reverse Transcriptase with genetic modifications to abolish RNase H activity to achieve thermal stability. This special mutant enzyme offers...

Reverse TranscriptasesM1174 | Novo™ Reverse Transcriptase DataSheetSort Name: Novo™ Reverse TranscriptaseLabel Name: Novo™ Reverse TranscriptaseTaglines: Reverse TranscriptasesProduct Highlights:...

Two Step RT PCR KitM1161 | Novo™ Two Step RT Kit DataSheetSort Name: Novo™ Two Step RT KitLabel Name: Novo™ Two Step RT KitTaglines: Two Step RT PCR KitProduct Highlights: Two Step RT PCR...

3665 | Noxa Antibody DataSheet

3665BP | Noxa Blocking Peptide DataSheetAntibody Target: Noxa Accession #: AAH32663Gene ID: 5366Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

5384 | NP-1 Antibody DataSheet

Defensins ( and ) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The -defensins which include NP-1, NP-2 and NP-3,...

A 10% soultion of NP-40 in water.2111 | NP-40 (10% in H₂O) DataSheetSort Name: NP-40Label Name: N/ATaglines: 10% NP-40 solutionProduct Highlights: • Alternate Name/Synonyms:...

A non-ionic surfactant, used to solubilize cerebral GABA receptors and for solubilization of proteins and lipids of the scallop gill ciliary membrane and of membranes from breast cancer tumors.NP-40...

3425 | NPM Antibody DataSheet

NQDI-1 is a specific inhibitor of apoptosis signal-regulating kinase 1 (ASK1) (IC₅₀ = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein...

3639 | NQO1 Antibody DataSheet

3639BP | NQO1 Blocking Peptide DataSheetAntibody Target: NQO1Accession #: P15559Gene ID: 1728Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

NQO1 human intracellular Elisa Kit | K4926

NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD (P)H as an electron donor. Thus NQO1 acts as a...

NQTrp is an inhibitor of amyloid β (Aβ) oligomerization and fibrillization, with an IC₅₀ of 50 nM for formation of fibrils from Aβ1-42. It reduces the cytotoxic effect of Aβ oligomers in rat PC12...

NRF2 Human Transcription Factor Activity Assay Kit | E4337

NRG4 belongs to the neuregulin family and contains 1 EGF-like domain. The protein is low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors,...

NS-11021 is a novel KCa1.1 channel activator. At concentrations above 0.3 μM, activates KCa1.1 in a concentration-dependent manner by parallel-shifting the channel activation curves to more negative...

NS-1619 is a calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels in vascular smooth muscle. Induces a concentration-dependent decrease in mitochondrial membrane...

NS-1643 is a hERG (Human ether-a-go-go related gene) K⁺channel activator with EC₅₀ of 10.5 μM. It shows antiarrhythmic activity in vitro and exhibits different molecular mechanisms of action at KV11...

NS-3763 is a selective non-competitive kainate receptor antagonist. It displays selectivity for GLUK5 subunit-containing receptors (IC₅₀ values are 1.6 and > 30 mM for homomeric GLUK5 and GLUK6...

NS6180 is a novel potent and selective KCa3.1 channel inhibitor (IC50= 9nM) prevents T-cell activation and inflammation.NS6180 is a novel potent and selective KCa3.1 channel inhibitor (IC50= 9nM)...

Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis...

NSC 210902 inhibits casein kinase 2 (CK2) with an IC₅₀ value of 1 μM. It competitively inhibits binding of ATP with a Ki value of 0.28 µM. It minimally inhibits protein kinases JNK3, GSK3, Cdk5, MSK1...

A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam 1 (IC₅₀ = 50 μM) without affecting...

NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L). It...

Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human...

NSC-139021 (ERGi-USU) is a highly selective inhibitor for the growth of ERG-positive cancer cells with IC₅₀s ranging from 30 to 400 nM. NSC-139021 displays minimal effect on normal prostate or...

NSC-19630 (MIRA-1) is a cell-permeable inhibitor of Werner syndrome WRN helicase activity (IC₅₀ = 20 µM) over its ATPase and exonuclease activities, but did not affect other DNA helicases [Bloom...

NSC-207895 is a cell-permeable benzofuroxan derivative that acts as a MDMX inhibitor (IC₅₀ = 2.5 µM). Activates p53 and induces apoptosis in cancer cells. Active in vitro and in vivo.NSC-207895 is a...

NSC-23925 is a potent plasma membrane glycoprotein 1(Pgp1) inhibitor. It inhibits Pgp1 and reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 directly inhibits the function...

NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft...

NSC-348884 is a nucleophosmin inhibitor that disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC₅₀ of 1.4-4.0 μM in distinct cancer cell lines.NSC-348884 is a...

NSC-5844 is a bisquinoline molecule that displays C-C chemokine receptor type 1 (CCR1) agonistic properties.NSC-5844 is a bisquinoline molecule that displays C-C chemokine receptor type 1 (CCR1)...

NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC₅₀ of NSC-59984 in most cancer cells is significantly lower than...

NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is...

NSC-663284 is a potent, selective and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC₅₀ = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). Displays > 20-...

Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in...

NSC-697923 is a selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-κB activation inhibitor. Inhibits proliferation and survival...

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 and 318 nM, respectively). It is much less effective against other protein tyrosine...

NSC109116 is an inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), an aldo-keto reductase (AKR) enzyme. AKR1C1 metabolizes progesterone to an inactive form, 20α-hydroxy progesterone...

3541 | NSF Antibody DataSheet

3541BP | NSF Blocking Peptide DataSheetAntibody Target: NSF Accession #: P46460Gene ID: 18195Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

NT-157 | B2087

5306 | NT-3 Antibody DataSheet

NT-3 is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. The active form of human NT-3 is a dimer, formed by two identical 119 amino acid subunits,...

NT-3 is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. Murine NT-3 produced from E. coli contains 119 amino acid and having a molecular mass is...

5309 | NT-4 Antibody DataSheet

Neurotrophin-4 (NT-4/NT-5) is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. The active form of human NT-4 is a dimer, formed by two identical...

NT5C3B, also known 7-methylguanosine phosphate-specific 5'-nucleotidase, includes transferase activity and nucleotide binding. Among its related super-pathways are adenosine nucleotides degradation...

3838BP | NTAL/LAB Blocking Peptide DataSheetAntibody Target: NTAL/LAB Accession #: Q8CGL2Gene ID: 317676Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

A potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC₅₀ = 400 nM). Useful to study the regulation of deoxyribonucleic acid repair by PARP enzyme.NU 1025 is a potent poly(ADP-ribose) polymerase...

NU-7026 is a potent DNA-PK inhibitor (IC₅₀ of 0.23 μM); displays 60-fold selectivity for DNA-PK than PI3K and inactive against both ATM and ATR.NU-7026 is a potent DNA-PK inhibitor (IC₅₀ of 0.23 μM);...

NU-7441 is a potent and selective DNA-PK inhibitor (IC₅₀ = 14 nM). Displays selectivity for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Also enhances CRISPR-Cas9-mediated...

A potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC₅₀ values of 9.5 and 5.4 nM, respectively. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC₅₀ = 1.6 μM), DYRK1A (IC₅₀ = 0.9...

K266 | Nuclear/Cytosol Fractionation Kit DataSheet

Nucleophosmin is a nucleus protein which belongs to the nucleoplasmin family. It is a nucleolar phosphoprotein that shuttles between the nucleus and cytoplasm during the cell cycle. Nucleophosmin /...

6663 | Nucleophosmin Antibody DataSheet

6782 | Nucleostemin/GLN3 Antibody (CT) DataSheet

Nucleozin is an antiviral agent that triggers the aggregation of nucleoprotein (NP) and inhibits its nuclear accumulation. Nucleozin impedes influenza A virus replication in vitrowith a nanomolar...

Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b), p53 pathway activator, and apoptosis inducer.Nutlin-3 is a Mdm2 (mouse...

Nutlin-3b is less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 inhibitor in comparison with more potent opposite (-)-enantiomer Nutlin-3a. Nutlin-3b may be used as negative control for non-MDM2...

NVP-231 is a potent and reversible inhibitor of ceramide kinase (CerK) (IC₅₀ = 12 nM). It displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.NVP-231 is a...

NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase.NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase.B1335 | NVP-AEW541 DataSheetAlternate Name/Synonyms:...