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Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently inhibits Th1 and Th2 differentiation and to a lesser extent...

Filipin III is a polyene macrolide antibiotic isolated from Streptomyces filipinensis. It may be used in a double staining procedure for the detection of lipoproteins. Binds specifically to...

FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS)...

FTY720 can be phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). IC₅₀ of (S)- and (R)-...

FIPI is a potent and selective phospholipase D (PLD) inhibitor. FIPI inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC₅₀ = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell...

FIPI is a potent phospholipase D (PLD) inhibitor. FIPI inhibits both PLD1 (IC₅₀ = 25 nM) and PLD2 (IC₅₀ = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and...

Fire Start DNA Polymerase | M1149

Fire Start Pcr Mix | M1141

Fire Start Pcr Mix-Dye | M1142

's FireTaq™ DNA Polymerase™ is a strategically-engineered, next generation Taq Polymerase that has rapid expansion rates, robust performance and contains a proprietary antibody that blocks polymerase...

Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and selective cyclooxygenase (COX)-2 inhibitor with an IC₅₀ of 0.13 uM. Displays 58-fold selectivity for COX-2 vs...

3491 | Fis1 Antibody DataSheet

3491BP | Fis1 Blocking Peptide DataSheetAntibody Target: Fis1 Accession #: Q9Y3D6Gene ID: 51024Appearance: Colorless liquidConcentration: 1.0mg/mlFormulation: 50 µg (1 mg/ml) Fis1 peptide in...

3491R | Fis1 Polyclonal Antibody DataSheet

FITC-D(OMe)E(OMe)VD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase inhibitor D(OMe)E(OMe)VD(OMe)-FMK that acts as an in situ marker for detection of...

FITC-IE(OMe)TD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase-8 inhibitor IE(OMe)TD(OMe)-FMK that acts as an in situ marker for detection of caspase-8 in...

FITC-LE(OMe)HD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase-9 inhibitor LE(OMe)HD(OMe)-FMK that acts as an in situ marker for detection of caspase-9 in...

Tyramide signal amplification is an enzyme-catalyzed deposition of tyramide on or near a protein or nucleic acid in situ. The enzyme horseradish peroxidase (HRP) converts the labelled tyramide...

FITC-VAD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable pan-caspase inhibitor VAD(OMe)-FMK that acts as an in situ marker for detection of caspase in living cells...

FITC-VD(OMe)VAD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase-2 inhibitor VD(OMe)VAD(OMe)-FMK that acts as an in situ marker for detection of caspase-2 in...

K1425 | Fite's Stain Kit DataSheet

FITM is a potent mGlu1 inhibitor. It displays high affinity and selectivity for mGlu1 over mGlu5.FITM is a potent mGlu1 inhibitor. It displays high affinity and selectivity for mGlu1 over mGlu5.B1859...

A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12),...

Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an...

A natural prodrug that inhibits Class I histone deacetylases (HDACs) (IC₅₀ values are: 36, 47, 510 and 14000 nM for HDAC1, HDAC2, HDAC4 and HDAC6, respectively). Displays potent anticancer activities...

3635 | FKBP12 Antibody DataSheet

3635BP | FKBP12 Blocking Peptide DataSheetAntibody Target: FKBP12Accession #: P26883Gene ID: 14225Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3666 | FKBP38 Antibody DataSheet

3666BP | FKBP38 Blocking Peptide DataSheetAntibody Target: FKBP38 Accession #: AY225340Gene ID: 14232Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3880 | FKBP52/Hsp56 Antibody DataSheet

3880BP | FKBP52/Hsp56 Blocking Peptide DataSheetAntibody Target: FKBP52/Hsp56 Accession #: NP_034349Gene ID: 14228Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

A1030 | Flag-Tag Monoclonal Antibody DataSheet

Cell-permeable. Flavopiridol is a synthetic flavonoid compound used as an anticancer agent. It is a serine/threonine kinase inhibitor that broadly targets cyclin-dependent kinases (CDKs), including...

A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other...

Flt3-Ligand belongs to a small group of growth factors that regulate proliferation of early hematopoietic cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant form is the...

The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain...

5085R | Flt3 Ligand Antibody DataSheet

Human flt3-Ligand (flk2-ligand) stimulates the proliferation and colony formation of certain bone marrow precursor cells including CD34+ cells. Recombinant human flt3-ligand is a soluble 17.6 kDa...

Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection...

Flucytosine, a fluorinated pyrimidine analog that displays antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. Flucytosine inhibits...

A chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine...

Fluo-4 is a widely used green fluorescent, intracellular calcium (Ca²⁺) indicator. Fluo-4 AM is the membrane permeable form of the calcium indicator. Masking the negative charge using non-polar,...

offers low price and high-quality Fluorescent Dye Labeled siRNA Oligos. All our siRNA oligos undergo vigorous process monitoring and strict quality control. Length and labeling are systematically...

K817 | Fluorescent Protein Antibody Set DataSheet

100 µg of each of the six fluorescent proteins including the Enhanced Green fluorescent protein (EGFP), dsRed and mCherry Red fluorescent proteins, Blue fluorescent protein (BFP), Yellow fluorescent...

ANQ is a highly sensitive, selective and turn-on sensor for Lead (II) and Aluminium (III). The detection limit for Pb²⁺ is 2.08 x 10-9 mol/L-1). Useful for detection of intracellular Pb²⁺/Al³⁺ within...

’s FluorLast™ Mounting Media is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. This unique formula prevents rapid photobleaching of FITC, Texas Red, AMCA, Cy2, Cy3,...

’s FluorLast™ with anti-fading agent 1, 4-Diazobicyclo-(2,2,2-octane (DABCO™) is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. This unique formula prevents rapid...

’s FluorLast™ with DAPI & anti-fading agent 1, 4-Diazobicyclo-(2,2,2-octane (DABCO™) is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. This unique formula prevents...

’s FluorLast™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. This unique formula prevents rapid photobleaching of FITC, Texas Red, AMCA, Cy2, Cy3, Cy5,...

K4205 | Fluoroquinolones Elisa Kit DataSheet

Fluvastatin sodium is a potent and selective HMG-CoA reductase inhibitor. It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits increases in serum...

Fluvastatin is a potent and selective HMG-CoA reductase inhibitor. It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits increases in serum...

Fluvoxamine is an inhibitor of 5-hydroxytryptamine (5-HT) re-uptake. It inhibits the uptake of 5-hydroxytryptamine in guinea-pig blood platelets with a pI₅₀ (the negative logarithm of the molar...

The reagent can be used as a negative control for FMK-labeled caspase inhibitors.Z-FA-FMK is a useul negative control for FMK-labeled caspase inhibitors.1122 | FMK Negative Control DataSheetAlternate...

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from...

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from...

K7425 | Follicle Stimulating Hormone [FSH] human Elisa Kit DataSheet

5708 | Follistatin Antibody DataSheet

Follistatin belongs to a group of structurally-diverse diffusible proteins that binds to TGF- ligands and inhibit their activity by hindering access to signaling receptors. This naturally occurring...

Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide...

E4532 | Folylpolyglutamate Synthase FPGS Human Elisa Kit DataSheet

Foretinib is an ATP-competitive multi-kinase inhibitor that suppresses the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In...

K653 | Formate Colorimetric Assay Kit DataSheet

Formestane is a steroidal aromatase inhibitor. It binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral...

Formoterol is a ß2-adrenergic agonist, and a long-term bronchodilator. It demonstrates a 330-fold selectivity for β2 over β1 receptors. Formoterol is used to manage asthma and in the treatment of...

Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP.Forskolin is an activator of adenylate cyclase leading to an increase in the intracellular concentration...

Fosaprepitant is a prodrug of Aprepitant (Cat. No. 9531) that acts as a selective, high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. After biologically activated to...

Fosinopril is the ester prodrug of fosinoprilat, an angiotensin converting enzyme (ACE) inhibitor. In vivo, fosinopril is rapidly hydrolyzed to fosinoprilat in the gastrointestinal mucosa and liver...

A potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor (IC₅₀ = 41 nM). Inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell...

Fostriecin is a potent inhibitor of the serine/threonine protein phosphatases PP2A and PP4 with IC₅₀ value of 3.2 and 3 nM, respectively. It also displays weak inhibition of topoisomerase II having...

Fotemustine is a third generation nitrosourea, chloroethylating agent with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine,...

3892 | FoxH1 Antibody DataSheet

3892BP | FoxH1 Blocking Peptide DataSheetAntibody Target: FoxH1Accession #: AAD14683Gene ID: 14106Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3742 | FoxL2 Antibody DataSheet

3742BP | FoxL2 Blocking Peptide DataSheetAntibody Target: FoxL2 Accession #: P27548 Gene ID: 668Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

Fork-head transcriptional factor forkhead box L2 (FOXL2) is a transcriptional regulator and a member of the large family of Forkhead Box (Fox) domain transcription factors. FOXL2 gene provides...

3673 | FOXO3a Antibody DataSheet

3673BP | FOXO3a Blocking Peptide DataSheetAntibody Target: FOXO3a Accession #: O43524Gene ID: 2309Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3709 | FOXP3 Antibody DataSheet

3709BP | FOXP3 Blocking Peptide DataSheetAntibody Target: FOXP3 Accession #: NP_473380Gene ID: 20371Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

K4224 | FOXP3 Human Elisa Kit DataSheet

FPH1 also known as Functional Proliferation Hit 1 induces functional proliferation of hepatocytes in vitro. It promotes the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps)...

FPH2 (BRD-9424) is a potent promoter of differentiation of iPS-derived hepatocytes. FPH2 induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes...

FPS-ZM1 is a high-affinity, brain-permeable, RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can...

FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1...

5088 | Fractalkine Antibody DataSheet

Human Fractalkine is a member of the newly discovered CX3C family of chemokines which contain both chemokine and mucin domain. Human Fractalkine is an 8.5 kDa protein containing 76 amino acid...

K270 | FractionPREP Cell Fractionation Kit DataSheet

FRAX597 is a potent group I PAK (p21-activated kinase) inhibitor (IC₅₀ values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Displays significant inhibition of YES1, RET, CSF1R and TEK at 100...

K612 | Free Fatty Acid Quantification Colorimetric/Fluorometric Kit DataSheet

K634 | Free Glycerol Colorimetric Assay Kit II DataSheet

K630 | Free Glycerol Colorimetric/Fluorometric Assay Kit DataSheet

FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in...

3836 | FRS2 Antibody DataSheet

3836BP | FRS2 Blocking Peptide DataSheetAntibody Target: FRS2 Accession #: NP_006645.3Gene ID: 10818Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

K450 | Fructosamine Assay Kit Colorimetric DataSheet

The conversion of fructose 1,6-bisphosphate to fructose 6 phosphate by fructose 1,6-bisphosphatase is the rate-limiting step during gluconeogenesis. The enzyme plays a role in regulating glucose...

K439 | Fructose Assay Kit Colorimetric DataSheet

K619 | Fructose Colorimetric/Fluorometric Assay Kit DataSheet