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GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM for Akt1, Akt2, and Akt3 respectively.GSK-2110183 is a potent, selective, and...

GSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC₅₀ of 0.8 nM, compared to wild...

Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ),...

GSK-2190915 sodium is a potent and selective FLAP (5-Lipoxygenase-activating protein) inhibitor (IC₅₀ of 2.6 nM); displays good selectivity over CYP3A4, 2C9, and 2D6. In an acute inflammation...

GSK-2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS (human Fatty Acid Synthase).GSK-2194069 is a potent and specific inhibitor of the β-ketoacyl reductase...

GSK-2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) (IC₅₀ = 10 nM). It does not suppress activity on other 96 kinases, including Aurora,...

GSK-2606414 is a potent and selective inhibitor of protein kinase R-like ER kinase (PERK) with IC₅₀ value of 0.4 nM. Displays >1000-fold selectivity for PERK over HR1 and PKR. GSK-2606414 inhibits...

GSK-2656157 is a potent, selective and ATP-competitive inhibitor of PERK (protein kinase R-like ER kinase) enzyme activity with an IC₅₀ of 0.9 nM; displays high selectivity for PERK against a panel...

GSK-269962 is a potent and selective Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). It displays >30-fold selectivity for ROCK against a...

GSK-269962 is a potent Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a...

GSK-2801 is a potent, selective and cell-permeable inhibitor of the BAZ2 family of bromodomain containing proteins. GSK-2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257...

GSK-2814338 is a potent Lp-PLA2 inhibitor useful for the treatment of atherosclerosis and Alzheimer's diseaseGSK-2814338 is a potent Lp-PLA2 inhibitor useful for the treatment of atherosclerosis and...

GSK-2879552 is a potent, selective, mechanism-based inactivator of Lysine Specific Demethylase 1 (LSD1)/ CoRepressor for Element-1-Silencing Transcription factor (CoREST) activity. GSK-2879552 binds...

GSK-2982772 is a potent and ATP-competitive receptor-interacting protein-1 (RIP1) kinase inhibitor (IC₅₀ = 1 nM).GSK-2982772 is a potent and ATP-competitive receptor-interacting protein-1 (RIP1)...

GSK-2983559 is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase.GSK-2983559 is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase.B2709 |...

Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5...

Glycogen synthase kinase-3 (GSK-3) is a serine/theronine kinase that was first characterized by its role in intermediary metabolism. In mammals, serine kinase is encoded by two related genes called...

GSK-3039294 is a potent small molecule inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils for the depletion of serum amyloid-P (SAP) component from the circulation.GSK-3039294 is...

GSK-3117391 is a potent histone deacetylase (HDAC) inhibitorGSK-3117391 is a potent histone deacetylase (HDAC) inhibitorB2375 | GSK-3117391 DataSheetAlternate Name/Synonyms:...

GSK-3326595 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 6.2 nM) that induces cell death in a broad range of solid and hematologic tumor cell lines. It...

GSK-3368715 is a potent, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4),...

GSK3484862 (GSKMI-714) is a selective, reversible, non-covalent DNMT1 (DNA Methyltransferase 1) inhibitor. Potently inhibits the methyltransferase activity of DNMT1, but not DNMT family members...

GSK-3787 is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) (plC₅₀ = 6.6). It covalently binds to Cys 249 in the PPARδ binding site.GSK-3787 is...

6676 | GSK-3? Antibody DataSheet

3493 | GSK-3a Antibody DataSheet

GSK-3 is one of the Akt substrates. It can be phosphorylated by Akt at Ser21 of GSK-3 or Ser9 of GSK-3. The phosphorylation of GSK negatively regulates its kinase activity. The recombinant GSK-3...

3494 | GSK-3b Antibody DataSheet

3494BP | GSK-3b Blocking Peptide DataSheetAntibody Target: GSK-3b Accession #: NP_002084 Gene ID: 2932Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2mg/ml) in phosphate...

A potent inhibitor of GSK-3β (Glycogen synthase kinase-3β) (IC₅₀ = 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate stem cell...

GSK-4112 is a selective agonist for REV-ERBα (EC₅₀ = 0.4 μM). At 10 μM, GSK-4112 can reset the circadian rhythm in a phasic manner by inhibiting expression of the circadian target gene bmal1 and...

GSK-484 is a potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK-484...

GSK-503 is a potent EZH2 inhibitor with potential anticancer activity. Increased activity of the epigenetic modifier EZH2 has been associated with different cancers. In a melanoma mouse model,...

GSK-583 is a highly potent and selective Inhibitor of RIP2 Kinase (IC₅₀ = 5 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation...

GSK-5959 is a potent and selective BRPF1 (BR140 or Peregrin) bromodomain inhibitor (IC₅₀ = 80 nM). GSK-5959 displays >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1...

GSK-626616 is a potent and selective DYRK inhibitor (IC₅₀ = 0.7 nM); inhibits other members of the DYRK family, e.g., DYRK1A and DYRK2, with similar potency. Displays ~20-fold selectivity over casein...

GSK-650394 is a potent inhibitor of serum- and glucocorticoid-regulated kinase (IC₅₀s = 62 and 103 nM for SGK1 and SGK2, respectively). It demonstrates greater than 30-fold selectivity for SGK1 over...

An ATP-competitive pan-Akt kinase inhibitor. Inhibits Akt kinase isoforms 1, 2, 3 with IC₅₀ values of 2, 13, and 9 nM, respectively. Inhibited proliferation and induced apoptosis in a subset of tumor...

GSK923295 is an allosteric inhibitor of CENP-E kinesin motor ATPase activity. It inhibits CENP-E microtubule-stimulated ATPase activity with a Ki of 3.2 ± 0.2 nM. It inhibits the growth of tumor cell...

GSK-961081 is a bi-functional molecule with both muscarinic antagonism and β2-agonism (MABA) properties. GSK-961081 displays high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3...

GSK-J1 is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ...

A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including...

GSK-J2 (sodium salt) is an isomer of GSK-J1. GSK-1 is a selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX, with an IC₅₀ of 60 nM for human JMJD3 in vitro. GSK-J2 poorly inhibits...

GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced...

Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (Cat. No. 2260-1, 5) (IC₅₀> 50 μM in vitro. When administered to human primary macrophages,...

GSK-J5 is an isomer of GSK-J4 and a prodrug for negative control GSK-J2. GSK-J2 is a negative control for GSK-J1, which is an inhibitor of the H3K27 histone demethylases JMJD3 and UTX. GSK-J5 did not...

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 2HCl irreversibly inhibits LSD1 with IC₅₀ value of 16 nM and is > 1000 fold selective over LSD2, MAO-A...

A potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 is highly selective against other methyltransferases and...

GSK-1278863 is a novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (HIF-PHI). Hypoxia-inducible factor−prolyl hydroxylase inhibitors stimulate endogenous EPO synthesis and induce effective...

GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12.5 nM. GSK1325756 displays anti-inflammatory effects in various preclinical and clinical models.GSK1325756 is a...

A potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.GSK1349572 is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that...

GSK137647A is a a selective agonist of FFA4 (GPR120) (pEC₅₀s = 6.3, 6.2, and 6.1 at human, mouse, and rat receptors, respectively). It is selective for GPR120 over a panel of 61 other targets,...

GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.B1628 |...

A potent, selective, reversible and ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) and Insulin Receptor (IR) with IC₅₀s of 27 and 25 nM, respectively.GSK1904529A is a...

GSK2190915 (Fiboflapon) is a potent FLAP (5-lipoxygenase-activating protein) inhibitor (IC₅₀ = 2.9 nM).GSK2190915 (Fiboflapon) is a potent FLAP (5-lipoxygenase-activating protein) inhibitor (IC₅₀ = 2...

GSK2256098 (GTPL7939) is a focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity. FAK is normally activated by integrin binding to extra cellular matrix...

GSK2292767 | B1660

GSK2330672 is a highly selective, potent, nonabsorbable ASBT(Apical Sodium dependent bile acid transporter) inhibitor (IC₅₀ = 42 nM). It lowers glucose in an animal model of type 2 diabetes...

GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows...

GSK2636771 is a potent, PI3Kβ-selective inhibitor, sensitive to PTEN cell lines.GSK2636771 is a potent, PI3Kβ-selective inhibitor, sensitive to PTEN cell lines.2793 | GSK2636771 DataSheetAlternate...

GSK2830371 is an allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor (IC₅₀ of 6 nM). It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition. Due to...

GSK-2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).GSK-2981278 is a highly potent and selective inverse agonist of...

A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation...

GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the...

A potent, selective and ATP-competitive inhibitor of Polo Like Kinase 1 (PLK1) (Ki = 2 nM). Displays >100-fold selectivity for PLK1 over PLK2 and PLK3. Shows anti-proliferative activity against...

Carrier of nitric oxide, relaxing smooth muscles and inhibiting platelet activation.GSNO is a carrier of nitric oxide, relaxing smooth muscles and inhibiting platelet activation.1580 | GSNO...

K263 | GST Colorimetric Activity Assay Kit DataSheet

K260 | GST Fluorometric Activity Assay Kit DataSheet

Effective inhibition of Glutathione S-transferase (GST) at the concentration of 2-20 µM.GST Inhibitor-1 (Cibacron Blue 3G-A, Sodium Salt) is an effective inhibition of Glutathione S-transferase (GST)...

An effective Glutathione S-transferase(GST) inhibitor at 2-100 µMGST Inhibitor-2 (Ethacrynic acid) is an effective Glutathione S-transferase(GST) inhibitor at 2-100 µM1556 | GST Inhibitor-2...

E4690 | GST Tag Elisa Kit DataSheet

Glutathione S-transferase is an enzyme in Bombyx mori (Silk moth) encoded by the GSTd2 gene. GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation...

3997 | GST-Tag Antibody DataSheet

A1021 | GST-Tag Monoclonal Antibody DataSheet

GSTA4, also known as glutathione S-transferase A4, belongs to the GST superfamily. This enzyme is involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic...

GSTK1 is a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification process. This protein catalyzes the conjugation of the thiol group...

Glutathione S-transferase mu 3, also known as GSTM3, is member of the glutathione s-transferase (GST) family of proteins. There are eight families of GST proteins, namely alpha, kappa, mu, omega, pi,...

Glutathione S-transferase mu 5, also known as GSTM5, is member of the glutathione s-transferase (GST) family of proteins. There are eight families of GST proteins, namely alpha, kappa, mu, omega, pi,...

GSTO1, also known as p28 or GSTTLp28, is a protein that localizes to the cytoplasm and contains both an Nterminal and a C-terminal GST domain. In mouse, the encoded protein acts as a small stress...

A1003 | GSTP1 Antibody DataSheet

GSTP2 also known as Glutathione S-transferase P2. Glutathione S-transferases are multifunctional enzymes involved in the protection of cellular components against anti-cancer drugs or peroxidative...

E4546 | GTPase KRas KRAS Human Elisa Kit DataSheet

Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with anti-hypertensive activity. It shows Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand...

A solution (6 M) of Guanidine Hydrochloride in de-ionized water.Guanidine hydrochloride (6 M) is a sterile-filtered solutionB1013 | Guanidine hydrochloride (6 M) solution DataSheetAlternate...

6654 | Guanosine Antibody DataSheet

GUK1, also known as GMK, belongs to the guanylate kinase family. This protein exists as a monomer that catalyzes the ATP-dependent conversion of GMP to GDP, thereby playing an essential role in the...

GV-58 is a Roscovitine (Cat. No. 1950) derivative that acts as a selective N- and P/Q-type Ca²⁺-channel agonist. These Ca2²⁺-channels regulate transmitter release in synapses. Potential lead compound...

GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-α-mediated sphingomyelin...

GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) with pEC₅₀ of 7.32; 100-fold selective against GPR120. Inactive against a range of other GPCRs, kinases,...

A Potent, selective and irreversible PPARɣ antagonist. Blocks the PPARɣ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.GW 9662 is a potent, selective and irreversible...

GW 0742 is a potent and selective PPARδ agonist (EC₅₀ = 1.1 nM) that displays 1,000-fold selectivity over other human PPAR subtypes. Therapeutically has shown to have effect on pulmonary damage,...

GW-311616 hydrochloride is a potent and selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine...

GW-3965 hydrochloride is a non-steroidal liver X receptor agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα...

GW-4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC₅₀ = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves...

GW-441756 is potent and specific inhibitor of Trk A (tropomyosin-related kinase A) tyrosine kinase (IC₅₀ = 2 nM). This inhibition of TrkA reduces cell proliferation and enhances the effects of...

Cell-permeable. A potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective...

GW-6471 is a potent PPARα antagonist (IC₅₀ = 240 nM). It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor. GW-6471...

GW-7647 is a potent, selective agonist of human and murine PPARα. It activates human PPARα, PPARγ, and PPARδ with EC₅₀ values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay...

Cell-permeable. A potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor and c-kit,...

GW-806742X is a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, as well as a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of...

GW1100 is an antagonist for the free fatty acid receptor FFAR1 (GPR40). It inhibits GPR40-mediated Ca2+ elevations stimulated by GW 9508 (agonist for GPR40 and GPR120) and linoleic acid with pIC₅₀...