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6856 | JARID2 polyclonal antibody DataSheet

A cell- permeable, non-fluorescent F-actin probe. Displays antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization, Jasplakinolide competes with phallotoxins...

Jatrorrhizine is a a novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb coptidis rhizome. Protects neuronal-like cells against H₂O₂-induced toxicity. JAT also displays...

JC-1 is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher...

Murine JE (also known as Macrophage/Monocyte Chemotactic Protein) is a 13.8 kDa protein containing 125 amino acid residues. It plays an important role in the inflammatory response of blood monocytes...

Cell-permeable. Structurally similar to cyclopamine (Cat. No. 1578). Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in...

JFD00244 is an inhibitor of SIRT2. SIRT2 is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. A major substrate of SIRT2 is α-tubulin. JFD00244 inhibits SIRT2 with an IC₅₀ of 56.7 µM...

JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation...

JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits...

3784 | JIK Antibody DataSheet

3664 | JIP-1 Antibody DataSheet

3664BP | JIP-1 Blocking Peptide DataSheetAntibody Target: JIP-1 Accession #: Q9WVI9Gene ID: 19099Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC₅₀ = 210 nM).JK...

3736 | JLP Antibody DataSheet

Cell-permeable. A slow-release prodrug version of Ro 61-8048 (Cat. No. 1912-5, 25), an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to...

3439BP | JMJ1DC Blocking peptide DataSheetAntibody Target: JMJ1DCAccession #: Q15652Gene ID: 221037Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3273 | JMJD1A Antibody DataSheet

3273BP | JMJD1A Blocking Peptide DataSheetAntibody Target: JMJD1AAccession #: Q9Y4C1Gene ID: 55818Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3439 | JMJD1C Antibody DataSheet

6108 | JMJD2A Antibody DataSheet

6851 | JMJD2a polyclonal antibody DataSheet

6852 | JMJD2b polyclonal antibody DataSheet

6853 | JMJD2c polyclonal antibody DataSheet

6109 | JMJD6 Antibody DataSheet

JNJ-10198409 is a potent, cell-permeable, ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell...

Cell-permeable. A potent , selective and reversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC₅₀ = 12 nM. Displays100-fold...

JNJ-17203212 is a reversible and potent antagonist of transient receptor potential vanilloid 1 (TRPV1) with pKi values of 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively. It Inhibits...

JNJ-26481585 is a second-generation pyrimidyl-hydroxamic acid histone deacetylase (HDAC) inhibitor with high cellular potency towards Class I and II HDACs. It displays potent antineoplastic...

A novel p53-activating tryptamine derivative that acts as a HDM2 (Human Double Minute-2) antagonist with potential antineoplastic activity. JNJ-26854165 inhibits the binding of the HDM2–p53 complex...

JNJ-27018966 is an orally active μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, with powerful antidiarrheal and analgesic activity. It is believed to act locally in the enteric...

JNJ-31020028 is a selective brain -penetrant small molecule antagonist of the neuropeptide Y2 (NPY2) receptor.JNJ-31020028 is a selective brain -penetrant small molecule antagonist of the...

JNJ-38877605 is a potent c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (IC₅₀ values of 4 nM and 50 nM for c-MET enzyme and Phospho-MET respectively). Displays...

JNJ-42041935 is a HIF-PHD (Hypoxia-inducible factor- prolyl hydroxylase) inhibitor. JNJ-42041935 is a selective, 2-OG (2-oxoglutarate) competitive, and reversible inhibitor of PHD enzymes (pKis = 7...

JNJ-47965567 is a potent and selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux. JNJ-47965567...

JNJ-64619178 is a selective and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 of 0.14 nM). It inhibits the growth of various cancer cells in vitro and reduces tumor...

JNJ-7706621 is a potent inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases with IC₅₀ values of 9 nM, 4 nM, 11 nM and 15 nM for CDK1, 2 and Aurora A, B, respectively. In vitro assays shows...

Jurkat cells are cultured in RPMI medium supplement with 10% FBS. The cells were grown to late growing phase. Anisomycin is added to the medium to a final concentration 10 µg/ml ( cat# 1549-10,...

K431 | JNK Activity Assay Kit, KinaseSTAR DataSheet

K430 | JNK Activity Screening Kit, KinaseSTAR DataSheet

3701 | JNK Antibody DataSheet

3701BP | JNK Blocking Peptide DataSheetAntibody Target: JNK Accession #: P45983Gene ID: 5599Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

The cell Lysate prepared from uninduced Jurkat cells can be used as a negative control for JNK activity assays in conjunction with ’s JNK Activity Assay Kit (K430-40 or K431-40). We recommend using...

JNK-IN-7 is a selective JNK inhibitor with IC50 values of 1.54 nM, 1.99 nM, 0.75 nM to JNK1, JNK2, JNK3, respectively. It also inhibits phosphorylation of c-Jun, which is a direct substrate of JNK...

JNK-IN-8 is a potent and irreversible JNK inhibitor that inhibits the phosphorylation of c-Jun. It inhibits JNK1, JNK2 and JNK4 with IC₅₀ values of of 4.7 nM, 18.7 nM and 1 nM, respectively.JNK-IN-8...

JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation...

JTE-607 is a multiple cytokine inhibitor. It inhibits cytokine production specifically in human peripheral blood mononuclear cells without causing immunosuppression. It inhibits tumor necrosis...

JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E,...

PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal...

The cytosolic extract was prepared from Jurkat cells induced with 2 µM camptothecin. The extract can be used as a positive control for caspase activity assays or for Western blotting. We recommend...

The cytosolic extract prepared from uninduced Jurkat cells can be used as a control for caspase activity assays or for Western blotting. We recommend using 100-200 µg per assay for caspase activity...

Jurkat cells were treated with 2 mM camptothecin for 6 hours. Cell lysate was prepared by homogenization in modified RIPA buffer (150 mM NaCl, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic...

The Jurkat cell lysate was prepared by homogenization in modified RIPA buffer (150 mM NaCl, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl flouride, 1% Triton...

JW55 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the β-catenin...

6206 | JWH-250, Synthetic Cannabinoid Antibody DataSheet

JZL-184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain...

JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) (IC₅₀ = 2 nM) and fatty acid amide hydrolase (FAAH) (IC₅₀ = 4 nM), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol...

K-604 is an inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1). The IC₅₀ values of K-604 for human ACAT-1 and ACAT-2 are 0.45 μM and 102.85 μM respectively, showing that K-604 is 229-fold...

K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α. K7174 also ameliorated anemia...

K-777 is a potent and irreversible cysteine protease inhibitor. Also acts as a potent cysteine protease cruzain (cruzipain) inhibitor. Active against Trypanosoma cruzi the causative agent of Chagas'...

A potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5...

Increasingly, researchers are focusing on the role poly-ubiquitin chains linked through K11. This post-translational modification has been linked to the ERAD cycle as a signal, similar to K48...

Increasingly, researchers are focusing on the role poly-ubiquitin chains linked through K11. This post-translational modification has been linked to the ERAD cycle as a signal, similar to K48...

Increasingly, researchers are focusing on the role poly-ubiquitin chains linked through K11. This post-translational modification has been linked to the ERAD cycle as a signal, similar to K48...

6205 | K2/spice, Synthetic Cannabinoids Antibody DataSheet

An analog of Staurosporine (Cat. No. 1048) that acts as a non-selective protein kinase inhibitor. Iinhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). Potently inhibits CaMK (Ki = 1.8...

Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post-translational...

Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post-translational...

Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post-translational...

Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. ...

Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. ...

Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. ...

K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 µM) and an antitumor agent. Induces cell death in cancer cells, blocks centrosome separation, activates the spindle...

A naturally occurring polyphenol antioxidant that displays a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective,...

A conformationally restricted glutamate analog that acts as a selective agonist at kinate receptors. A CNS stimulant and neurotoxin. Classic neuroexcitatory agent for induction of seizures in...

3720BP | Kallikrein 12 (KLK12) Blocking Peptide DataSheetAntibody Target: Kallikrein 12 (KLK12) Accession #: AAH35385.1Gene ID: 43849Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation:...

3720 | Kallikrein 12 (KLK12) Antibody DataSheet

A serine protease that releases bradykinin from kininogen. Present in plasma as an inactive precursor prokallikrein.4093 | Kallikrein Human Plasma DataSheetBiomolecule/Target: KallikreinSynonyms:...

KLK2 is a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array...

E4279 | Kallistatin Human Elisa Kit DataSheet

K4210 | Kanamycin Elisa Kit DataSheet

Kanamycin, USP is an aminoglycoside antibiotic often used to select for bacteria which have been successfully transformed with a plasmid conferring kanamycin resistance. Kanamycin interacts with the...

3764 | KAP-1 Antibody DataSheet

Cell-permeable. Kartogenin promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes (EC₅₀ = 100 nM). Displays chondroprotective effects in vitro and is...

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor with IC₅₀ values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively. More potent analog of CID-755673 (Cat.No. 2660) with 7-fold...

5211 | KC Antibody DataSheet

5212BP | KC Blocking Peptide DataSheetAntibody Target: KC Accession #: AAH37997Gene ID: 14825Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

KC7F2 is a small molecule HIF-1 pathway inhibitor that inhibits HIF-1α protein translation, but not transcription. It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic...

KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro...

6847 | KDM1B polyclonal antibody DataSheet

Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. In addition, it has been found to be a...

Keratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia and is...

Ketoconazole is a broad-spectrum triazole antifungal agent. It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol biosynthesis...

Ketorolac is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selectively inhibits the enzymes COX-1 and COX-2. The...

Kevetrin is a water-soluble, small molecule activator of the tumor suppressor protein p53, with potential antineoplastic activity. p53 functions by activating proteins that repair DNA and kill cells...

KG-501 is a cAMP response element-binding protein (CREB) inhibitor that disrupts CREB-dependent transcription (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM).KG-501 is a cAMP response...

5050 | KGF/FGF-7 Antibody DataSheet

A selective inhibitor of soluble adenylyl cyclase (sAC) ( IC₅₀ = 3-10 µM in vivo). Displays little effect on transmembrane adenylyl cyclases. KH7 is not active against sAC in the presence of...

KHS-101 is a selective inducer of neuronal differentiation. It induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). Also...

Ki 16425 is a LPA (Lysophosphatidic acid) receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors,...

Ki 8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC₅₀ = 0.9 nM). It is >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR.Ki 8751...