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An anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity...

Mivebresib is a potent BET inhibitor with potential antineoplastic activity. It disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in...

Mizoribine is an imidazole nucleoside that acts as an immunosuppressive agent and HCV RNA replication inhibitor (IC₅₀ = 100 μM). Inhibits T and B cell proliferation. Anti-bacterial, antiviral,...

A potent and selective antagonist of the neuropeptide Y (NPY) receptor Y5. It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion...

MK-0752 is a potent and reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells (IC₅₀ = 5 nM). Through its effects on the Notch pathway, MK-0752...

MK-0941 is selective, allosteric glucokinase activator (GKA) that activates glucokinase (hexokinase subtype IV) with greater selectivity than over different hexokinase isoforms. MK-0941 shows...

MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.B1641 | MK-1064...

MK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and...

MK-1775 is a potent and selective inhibitor of the tyrosine kinase WEE1 (IC₅₀ = 5.2 nM). It selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1...

A highly selective non-ATP competitive allosteric Akt inhibitor with IC₅₀’s of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³⁰⁸ and...

MK-2461 | B3359Description: MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibits in vitro phosphorylation of a peptide substrate recognized by wild-type or...

MK-3102 is a potent, selective and long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor with IC₅₀ of 1.6 nM; highly selective over other proteases (QPP, DPP8, and FAP) tested.MK-3102 is a potent,...

MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator (EC₅₀ = 8 nM).MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator (EC₅₀ = 8 nM).B2431 |...

MK-4101 is a potent and selective inhibitor of the Hedgehog (Hh) signaling pathway. It displays potent activity against medulloblastoma and Basal Cell Carcinoma (BCC). MK-4101 shows anti-tumor...

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumor models with loss of BRCA and...

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and...

MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nMMK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nMB1344 | MK-5108 DataSheetAlternate Name/Synonyms:...

MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease...

MK-571 sodium is the sodium salt of the multidrug resistance protein-1 (MRP1) inhibitor MK-571 (Cat. No. 2691).MK-571 sodium is a selective, CysLT1 receptor antagonist. It blocks the binding of...

MK 571 is a selective, CysLT1 receptor antagonist. It blocks the binding of leukotriene LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively...

MK-0591 sodium is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and...

MK-0591 is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and platelet...

MK-7655 is a potent and selective β-lactamase inhibitor. It restores imipenem-susceptibility in imipenem-resistant K. pneumoniae and P. aeruginosa when used at concentrations of 12.5 and 4.7 μM,...

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.MK-8745 is a novel Aurora-A specific...

MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5...

MK-8931 is a potent BACE1 inhibitor. MK-8931 binds significantly to β-secretase.MK-8931 is a potent BACE1 inhibitor. MK-8931 binds significantly to β-secretase.B1315 | MK-8931 DataSheetAlternate...

MK-8998 is a potent and selective antagonist of T-type calcium channel. Could be potentially useful for the treatment of schizophrenia.MK-8998 is a potent and selective antagonist of T-type calcium...

MKC-8866 is a potent, and selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC-8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression...

E4308 | MKI67 Human Elisa Kit DataSheet

3285 | MKK3 Antibody DataSheet

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ...

ML-193 is a selective quinoline aryl sulfonamide antagonist for GPR55, a lysophosphatidylinositol (LPI)-sensitive receptor that is also involved in cannabinoid signaling. It inhibits GPR55 with an...

ML-204 is a selective blocker of TRPC4 channels. Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; shows no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8...

ML-210 is a selective and covalent inhibitor of glutathione peroxidase 4 (GPX4). ML-210 binds the GPX4 selenocysteine residue. It reduces viability of mesenchymal-state KP4 cells, an effect that can...

ML-216 is a potent and selective inhibitor of BLM (Bloom) helicase (IC₅₀ = 1.8 μM); it displays 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At...

ML-228 is an activator of the Hypoxia Inducible Factor (HIF) signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 µM), HIF-1α nuclear translocation assay (EC50...

ML-240 is an ATP-competitive inhibitor of the D2 domain of the p97 ATPase (IC₅₀ = 110 nM). It disrupts the endoplasmic reticulum-associated degradation and autophagy pathways, preventing the...

ML-277 is a potent activator of KCNQ1 (Kv7.1) channels (EC₅₀ = 260nM). It displays >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1...

ML323 is a potent, reversible, inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and...

Cell-permeable. ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC₅₀ = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC₅₀ ~ 10 µM) and abrogates infection...

ML-335 is a potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels activator with EC₅₀ of 14.3 and 5.2 uM, respectively.ML-335 is a potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2)...

ML-354 is a selective PAR4 antagonist (IC₅₀ = 140 nM). Displays 71-fold selectivity for PAR4 over PAR1 (PAR-1 IC₅₀ = 10 μM).ML-354 is a selective PAR4 antagonist (IC₅₀ = 140 nM). Displays 71-fold...

ML-365 is a potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC₅₀ values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated...

ML-385 is a potent and selective Nrf2 inhibitor (Nrf2; IC₅₀ = 1.9 µM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1...

ML-7 hydrochloride is a selective MLCK (myosin light chain kinase) inhibitor (Ki = 0.3 μM). Displays reversible, ATP-competitive inhibition of Ca²⁺-calmodulin-dependent and -independent smooth muscle...

Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC₅₀ = 0.56±0.04 µM). Displays high...

ML133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor. It inhibits Kir2.1 with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. It is selective for Kir2 channels over Kir1.1 and Kir4.1...

Cell-permeable. A potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPase (IC₅₀ = 2.6 and 5.4 μM for Cdc42 wild type and activated mutant, respectively). No appreciable inhibitory...

ML161 is an allosteric Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC₅₀ = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Also...

A selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor. displays selectivity toward ABCG2 over ABCB1ML230 is a selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor...

ML239 is a selective inhibitor of breast cancer stem cells. It inhibits cancer stem cells with an IC₅₀ of 1.16 μM with 24-fold selectivity against the control cell line. ML239 alters the expression...

ML241 is a potent, selective, and reversible inhibitor of the AAA ATPase p97 (IC₅₀ = 100 nM). It blocks p97-dependent proteasome substrate with an IC₅₀ of ~ 3500 nM.ML241 is a potent, selective, and...

ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line...

3430 | MLK3 Antibody DataSheet

3798 | MLL1 Polyclonal Antibody DataSheet

A potent and selective inhibitor of NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8)-activating enzyme (NAE) (IC₅₀ = 4.7 nM) with potential anticancer activity. NAE activates...

MLN-8054 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 4 nM). Displays 40-fold selectivity for Aurora A over Aurora B.MLN-8054 is a potent and selective inhibitor of Aurora kinase A...

MLN-9708 is a prodrug of Ixazomib citrate (MLN-2238). MLN-9708 is an orally bioavailable next-generation proteasome inhibitor (PI) with potential potent anticancer activity in both hematologic and...

MLN 2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in clinical trials.MLN 2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in clinical trials.B1706 | MLN2480...

MLN8237 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ =1.2 nM). It displays >200-fold higher selectivity for Aurora kinase A over Aurora kinase B. Displays antineoplastic activity...

MLR-1023 is an allosteric activator of Lyn kinase (EC₅₀ = 63 nM). It reduces blood glucose levels without increasing insulin secretion in vivo. MLR-1023 does not activate peroxisome...

Cell-permeable. A potent and specific inhibitor of Cdc42, a small GTPase of the Rho subfamily (IC₅₀ = 2 µM).MLS-573151 is a potent and specific inhibitor of Cdc42, a small GTPase of the Rho subfamily...

MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both...

MMAE (Monomethyl auristatin E) is a synthetic derivative of dolastatin 10 that functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. Suppresses tumor cell viability in vitro...

MMP substrate, Fluorogenic is a widely used FRET substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, and MMP-16. Also acts as a substrate for Cathepsin D and Cathepsin E...

5781 | MMP-1 Antibody DataSheet

K794 | MMP-1 Inhibitor Screening Kit Fluorometric DataSheet

Active MMP-1 catalytic domain from human cDNA, expressed in E.coli and purified using proprietary technologies. The active MMP-1 protein is very useful in studying enzyme kinetics, cleave target...

MMP-10 (Human) ELISA Kit | E5075-100Description: Matrix metalloproteinase-10 (MMP-10) also known as Stromelysin-2 or transin-2 belongs to the family of matrix metalloproteinases. It is involved in...

3531R | MMP-11 Antibody DataSheet

3531RBP | MMP-11 Blocking Peptide DataSheetAntibody Target: MMP-11 Accession #: AAH52854Gene ID: 17385Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

MMP-12 (Human) ELISA Kit | E5081-100Description: Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase or macrophage elastase belongs to the matrix metalloproteinase family...

3732 | MMP-12 Antibody DataSheet

3532RBP | MMP-12 Blocking Peptide DataSheetAntibody Target: MMP-12 Accession #: NP_002417Gene ID: 4321Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2mg/ml) in phosphate...

3732BP | MMP-12 Blocking Peptide DataSheetAntibody Target: MMP-12 Accession #: NP_002417Gene ID: 4321Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

MMP-13 (Human) ELISA Kit | E5082-100Description: Matrix metalloproteinase-13 (MMP-13) also known as Collagenase 3 belongs to the matrix metalloproteinase family. These are involved in the breakdown...

3533 | MMP-13 Antibody DataSheet

3533BP | MMP-13 Blocking Peptide DataSheetAntibody Target: MMP-13 Accession #: P23097Gene ID: 171052Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

CL-82198 is a selective inhibitor of MMP-13 (IC₅₀ = 10 µM). It displays no activity against MMP-1, MMP-9 or TACE.CL-82198 is a selective inhibitor of MMP-13 (IC₅₀ = 10 µM). It displays no activity...

MMP-13 is a member of the matrix metalloproteinase (MMP) family of enzymes. MMP enzymes are associated with remodeling and breaking down matrix proteins. Aberrant expressions of different MMP enzymes...

K846 | MMP-14 Inhibitor Screening Kit Fluorometric DataSheet

The Matrix metalloproteinase-14 (MMP-14) belongs to a family of zinc-dependent endopeptidases. The ability of MMP-14 to degrade type I collagen, and activate pro-MMP-2 and pro-MMP-9 makes it a key...

MMP-16 (Human) ELISA Kit | E5083-100Description: Matrix metalloproteinase-16 (MMP-16) belongs to the matrix metalloproteinase family. These are involved in the breakdown of extracellular matrix in...

3537 | MMP-17 Antibody DataSheet

MMP-19 (Human) ELISA Kit | E5084-100Description: Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI belongs to the matrix metalloproteinase family. These are involved in...

MMP-2 Antibody | 5562

MMP-2 catalytic domain from human cDNA, expressed in E.coli and purified using proprietary technologies. The MMP-2 is useful as a standard in Western blot, etc.7782 | MMP-2 human recombinant...

MMP-24 (Human) ELISA Kit | E5076-100Description: Matrix metalloproteinase-24 (MMP-24) belongs to the family of matrix metalloproteinases. It is involved in the breakdown of extracellular matrix in...

MMP-25 (Human) ELISA Kit | E5077-100Description: Matrix metalloproteinase-25 (MMP-25) belongs to the family of matrix metalloproteinases which is involved in the breakdown of extracellular matrix in...

MMP-26 (Human) ELISA Kit | E5085-100Description: Matrix metalloproteinase-26 (MMP-26) also known as matrilysin-2 and Endometase belongs to the matrix metalloproteinase family. These are involved in...

MMP-3 (Human) ELISA Kit | E5078-100Description: Matrix metalloproteinase-3 (MMP-3) also known as Stromelysin-1 belongs to a family of matrix metalloproteinases. It is involved in the breakdown of...

K783 | MMP-3 Activity Fluorometric Assay Kit DataSheet

5783 | MMP-3 Antibody DataSheet

3523RBP | MMP-3 Blocking Peptide DataSheetAntibody Target: MMP-3 Accession #: P03957Gene ID: 171045Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

K793 | MMP-3 Inhibitor Screening Kit Fluorometric DataSheet

NFF-3 is a useful fluorogenic substrate for MMP-3 (stromelysin 1). NFF-3 is hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1 M-1) and very slowly by MMP-9 (kcat/Km = 10,100 s-1 M-1), but no...

Active MMP-3 catalytic domain from human cDNA, expressed in E.coli and purified using proprietary technologies. The active MMP-3 is very useful in studying enzyme kinetics, cleave target substrates,...

MMP-7 (Human) ELISA Kit | E5079-100Description: Matrix metalloproteinase-7 (MMP-7) also known as Matrilysin or pump-1 protease belongs to a family of matrix metalloproteinases consisting of...

MMP-8 (Human) ELISA Kit | E5080-100Description: Matrix metalloproteinase-8 (MMP-8) also known as Neutrophil collagenase or PMNL collagenase belongs to the family of matrix metalloproteinases of zinc-...

3528 | MMP-8 Antibody DataSheet