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A-485 is a potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC₅₀ values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). A-485...

A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.A-674563 is a potent,...

Cell-permeable. A potent AMPK activator. Directly stimulates partially purified rat liver AMPK (EC₅₀ = 0.8 µM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC5₅₀ = 3.2 µM).A-769662...

A-803467 is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Na(v1.8). Na(v1.8) is preferentially expressed in sensory neurons, and inhibition attenuates both...

A-803467 is a selctive a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM) and the generation of spontaneous and electrically evoked action potentials in...

A-839977 is a potent antagonist of the purinergic receptor P2X subtype 7 (P2X7). A-839977 potently blocks BzATP-induced calcium influx at recombinant human, rat and mouse P2X7 receptors with IC₅₀...

A-966492 is a potent PARP (poly (ADP-ribose) polymerase) inhibitor that displays potency against the PARP-1 enzyme with a K(i) of 1 nM and an EC₅₀ of 1 nM in a whole cell assay.A-966492 is a potent...

3401 | A1 Antibody DataSheet

3401BP | A1 Blocking Peptide DataSheetAntibody Target: A1 Accession #: Q16548Gene ID: 597Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

A calcium ionophore. Causes rapid influx of calcium in various cells.A23187 is a calcium ionophore. Causes rapid influx of calcium in various cells.1501 | A23187 DataSheetAlternate Name/Synonyms:...

A37 is a aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor (IC₅₀ = 4.6 μM; Ki = 300 nM). Displays selectivity for ALDH1A1 over eight other ALDH isoforms. A37 disrupts OC spheroid formation and cell...

A66 is a highly specific and selective p110α inhibitor with IC50 of 32 nM.A66 is a highly specific and selective p110α inhibitor with IC50 of 32 nM.B1654 | A66 DataSheetAlternate Name/Synonyms: A66;...

Physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks...

AA26-9 is a potent and broad-spectrum serine hydrolase inhibitorAA26-9 is a potent and broad-spectrum serine hydrolase inhibitorB2159 | AA26-9 DataSheetAlternate Name/Synonyms:...

3810 | AAK1 Antibody DataSheet

3810BP | AAK1 Blocking Peptide DataSheetAntibody Target: AAK1 Accession #: Q2M218 Gene ID: 57232Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC₅₀ = 130 nM), VEGFR-2 (IC₅₀ = 23 nM) and VEGFR-3 (IC₅₀ = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit...

Abacavir (ABC) is a brain-penetrant nucleoside analog that acts as a competitive reverse transcriptase inhibitor (NRTI); inhibits HIV replication. Antiretroviral agent.Abacavir (ABC) is a...

3246 | ABAD/HADH2 Antibody DataSheet

3246BP | ABAD/HADH2 Blocking Peptide DataSheetAntibody Target: ABAD/HADH2Accession #: O70351Gene ID: 63864Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Abametapir is a metalloprotease inhibitor potentially useful for the treatment of head lice infestation. It is the active ingredient of Xeglyze Lotion.Abametapir is a metalloprotease inhibitor...

ABBV-744 is a potent BDII (Bromodomain II)-selective (>100 X selectivity over BDI) BET bromodomain inhibitor. ABBV-744 inhibits proliferation of SKM-1 leukemia cells (IC50 = 6.7 nM). It induces cell...

ABC-1183 is a potent and selective dual GSK3α/β and CDK9 inhibitor.ABC-1183 is a potent and selective dual GSK3α/β and CDK9 inhibitor.B2221 | ABC-1183 DataSheetAlternate Name/Synonyms:...

ABC294640 is a specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity. This orally available aryl admantane molecule upon administration binds and inhibits SK-2, preventing...

6705 | ABCG1 Antibody (Center) DataSheet

6704 | ABCG1 Antibody (NT) DataSheet

K4188 | ABCG2 Human Elisa Kit DataSheet

Abexinostat is a broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. It inhibits several isoforms of HDAC, resulting in an...

Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nMAbiraterone (CB-7598) is a potent steroidal cytochrome P450...

ABL-001 is a potent allosteric inhibitor of BCR-ABL. ABL001 binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation. ABL001 prevents emergence of resistant...

A potent, small molecule Bcl-2 family protein inhibitor (Ki’s of

ABT-494 is a potent and selective Janus kinase JAK-1 inhibitor (IC₅₀ = 43 nM). ABT-494 is 74-fold more selective for JAK-1 over JAK-2 and 58-fold more selective for JAK-1 over JAK-3.ABT-494 is a...

A small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w. In vitro, ABT-737 binds Bcl-xL, Bcl-2 and Bcl-w with comparable high affinity, while it has over 1000-fold lower...

ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC₅₀ value of 4 nM), but has much less activity (IC₅₀ values >1 µM) against unrelated receptor...

Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and...

ABT751 is a potent inhibitor of microtubule polymerization. It binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell...

ABTS is considered a safe and sensitive substrate compatible for horseradish peroxidase (HRP) based ELISA assays. In the presence of hydrogen peroxide and HRP, ABTS is oxidized to a radical cation...

ABTS is considered a safe and sensitive substrate compatible for horseradish peroxidase (HRP) based ELISA assays. In the presence of hydrogen peroxide and HRP, ABTS is oxidized to a radical cation...

AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated...

AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and...

Ac-DEVD-CHO is a potent and reversible inhibitor of the Group II caspases, caspase-3 and caspase-7 (Ki's = 0.23 and 1.6 nM, respectively). The DEVD sequence is based on PARP cleavage site Asp-216 for...

Ac-IEPD-AFC is a useful fluorogenic substrate for the detection of Granzyme B. Granzyme B activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at 400 nm and...

Ac-VEID-pNA, is a colorimetric substrate for caspase-6 and related cysteine proteases. Cleavage of the substrate by a caspase results in the release of pNA, which can be detected by its absorbance at...

Ac-WEHD-AFC is a useful fluorogenic substrate for group I caspases (caspase-1, -4, and -5). Caspase activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at...

Ac-WEHD-pNA is a useful colorimetric substrate for group I caspases (caspase-1, -4, and -5). Cleavage of the substrate by a caspase releases pNA, which can be detected by its absorbance at 405 nm...

AC710 is a potent, and selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM,1.0 nM, 1.3 nM and 1.0 nM for FLT3, KIT, PDGFRα and PDGFRβ respectively. Displays potent anticancer activity...

3536 | ACAA1 Antibody DataSheet

3536BP | ACAA1 Blocking Peptide DataSheetAntibody Target: ACAA1Accession #: AAH 12400.1Gene ID: 113868Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3538 | ACAA2 Antibody DataSheet

3538BP | ACAA2 Blocking Peptide DataSheetAntibody Target: ACAA2Accession #: EDL 82881.1Gene ID: 170465Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3239 | ACAD-9 Antibody DataSheet

3239BP | ACAD-9 Blocking Peptide DataSheetAntibody Target: ACAD-9Accession #: B1WC61Gene ID: 294973Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3139BP | ACADL Blocking Peptide DataSheetAntibody Target: ACADLAccession #: P28330Gene ID: 33Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

3137 | ACADM Antibody DataSheet

3137BP | ACADM Blocking Peptide DataSheetAntibody Target: ACADMAccession #: P08503 Gene ID: 24158Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3539 | ACADS Antibody DataSheet

3539BP | ACADS Blocking Peptide DataSheetAntibody Target: ACADSAccession #: P15651.2Gene ID: 64304Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3150 | ACADSB Antibody DataSheet

3150BP | ACADSB Blocking Peptide DataSheetAntibody Target: ACADSBAccession #: Q9DBL1Gene ID: 66885Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3157BP | ACADSB Blocking Peptide DataSheetAntibody Target: ACADSBAccession #: Q9DBL1Gene ID: 66885Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3240BP | ACADVL Blocking Peptide DataSheetAntibody Target: ACADVLAccession #: P45953Gene ID: 25363Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3240 | ACADVL Polyclonal Antibody DataSheet

Acalabrutinib (ACP-196) is an orally available, selective irreversible inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. It is a second generation BTK inhibitor with...

Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.B1666 | Acalisib...

Acarbose is an inhibitor of α-glucosidase and pancreatic α-amylase with antihyperglycemic activity. Acarbose binds to and inhibits α-glucosidase, an enteric enzyme found in the brush border of the...

Acetyl-Coenzyme A acetyltransferase 2 (ACAT2) is an enzyme involved in lipid metabolism. Patients with ACAT2 deficiency have shown severe mental retardation and hypotonus. The ACAT2 gene shows...

3245 | ACAT1 Antibody DataSheet

3245BP | ACAT1 Blocking Peptide DataSheetAntibody Target: ACAT1Accession #: P17764Gene ID: 25014Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

E4366 | ACAT1 Human Elisa Kit DataSheet

3254BP | ACAT2 Blocking Peptide DataSheetAntibody Target: ACAT2Accession #: Q8CAY6Gene ID: 110460Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

E4367 | ACAT2 Human Elisa Kit DataSheet

Cell-permeable. A potent and selective inhibitor of ACC2 (Acetyl-CoA Carboxylase) (IC₅₀ = 28 nM for hACC2 vs 210 nM for hACC1 in in vitro studies).ACC2 inhibitor is a potent and selective inhibitor...

6703 | ACE Antibody (CT) DataSheet

ACE-2 substrate, Fluorogenic is a useful fluorogenic substrate for angiotensin converting enzyme-2 (ACE-2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike...

E4528 | ACE2 Human Elisa Kit DataSheet

DX600 is a potent ACE2 (Angiotensin-Converting Enzyme 2) inhibitor (Ki = 2.8 nM).DX600 is a potent ACE2 (Angiotensin-Converting Enzyme 2) inhibitor (Ki = 2.8 nM).9687 | ACE2 Inhibitor, DX600...

Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, that is used as an antiinflammatory drug in development for the treatment of CF and other diseases. Leukotriene A4 hydrolase (LTA4H)...

Acefylline is a xanthine derivative which acts as potential Peptidylarginine deiminase (PAD) activator. It increases the in vitro deimination of filaggrin by PAD1 and PAD3 at a concentration of 200...

Acetaldehyde Assay Kit (Fluorometric) | K2101-100Description: Acetaldehyde (ACH), also known as Ethanal, is one of the most important aldehydes occurring widely in nature and is also manufactured in...

K658 | Acetate Colorimetric Assay Kit DataSheet

Acetazolamide is a potent carbonic anhydrase (CA) inhibitor. It is currently used as an antiglaucoma, antiepileptic and diuretic agent, and is also effective in the treatment of Idiopathic...

A 50 mM solution of glacial acetic acid in de-ionized water.Acetic Acid (50 mM) is a 50 mM solution of glacial acetic acid in de-ionized water.2112 | Acetic Acid (50 mM) DataSheetAlternate...

K650 | Acetoacetate Colorimetric Assay Kit DataSheet

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. It inhibits the growth of struvite crystals produced by P. mirabilis in artificial urine...

Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic reactions. It is formed either by the oxidative decarboxylation of pyruvate, β-oxidation of fatty acids or oxidative...

Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key...

6125 | Acetyl Lysine (Biotin) Antibody DataSheet

Acetyl-CoA ELISA Kit | E5100-100Description: Acetyl-CoA is a component of cellular respiration that adds acetyl groups to biochemical reactions. These reactions are used in the metabolizing of...

3653 | Acetyl-Histone H2A Antibody DataSheet

3654 | Acetyl-Histone H2B Antibody DataSheet

A1029 | Acetyl-Lysine Monoclonal Antibody DataSheet

E4531 | Acetylated p53 Human Elisa Kit DataSheet

K764 | Acetylcholinesterase Activity Colorimetric Assay Kit DataSheet

K197 | Acetylcholinesterase Inhibitor Screening Kit Colorimetric DataSheet

6707 | ACHE Antibody (CT) (Clone 684CT8.3.4) DataSheet

6706 | ACHE Antibody (NT) DataSheet

K1424 | Acid Fast Bacteria Stain Kit DataSheet

K411 | Acid Phosphatase Activity Colorimetric Assay Kit DataSheet

K421 | Acid Phosphatase Activity Fluorometric Assay Kit DataSheet

K937 | Acid Phosphatase Cell Cytotoxicity Assay Kit DataSheet