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K192 | Acid Sphingomyelinase Assay Kit II Colorimetric DataSheet

K513 | Acidic Mammalian Chitinase Activity Kit Fluorometric DataSheet

K693 | Acidic Mammalian Chitinase Inhibitor Screening Kit Fluorometric DataSheet

Acivicin is an antibiotic that inhibits γ-glutamyl transpeptidase (γ-GT), an enzyme involved in transferring g-glutamyl groups in the cell membranes of kidneys, heart, brain, and pancreas. Acivicin...

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that is encoded by the TNK2 gene in humans. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine...

Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal...

Aclidinium bromide is a long-acting reversible antagonist at the muscarinic acetylcholine receptors (mAChRs), M1, M2, M3, M4, and M5 (Kis= 0.1, 0.14, 0.14, 0.21, and 0.16 nM, respectively). Useful...

K716 | Aconitase Activity Colorimetric Assay Kit DataSheet

Aconitine is diterpene alkaloid derived from the tubers of aconitinum plants. It is a neurotoxin that opens TTX(tetrodotoxin)-sensitive Na⁺ channels in the heart and other tissues, and is used for...

ACP5, also known as tartrate-resistant acid phosphatase type 5, is involved in osteopontin and bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states...

A potent and selective CRTh2 antagonist. CRTh2 is a G-protein-coupled receptor for prostaglandin D2 (PGD2), a key mediator in inflammatory disorders.ACT-129968 is a potent and selective CRTh2...

ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2, respectively. Displays anticancer activities.ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2...

A1051BP | ACTH Blocking Peptide DataSheetAntibody Target: ACTHAccession #: P01189Gene ID: 5443Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in PBS (pH 7.2) with 0...

A1051 | ACTH Polyclonal Antibody DataSheet

Adrenocorticotropic hormone, as its name implies, stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion...

K457 | Actin Polymerization/Depolymerization Assay Kit Fluorometric DataSheet

Actin is one of the major components of cytoskeleton, highly conserved and abundant proteins in eukaryotic cells. It is present as monomeric globular protein, called G actin or as a polymer filament,...

Actin is one of the major components of cytoskeleton, highly conserved and abundant proteins in eukaryotic cells. It is present as monomeric globular protein, called G actin or as a polymer filament,...

An antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and...

K427 | Activated Protein C APC Inhibitor Screening Kit Colorimetric DataSheet

The Activated Human Protein C was activated from homogeneous protein C by activation with purified alpha-thrombin. The alpha-thrombin is removed after activation. Complete activation is observed on...

AHCY (EC 3.3.1.1) is an enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). AHCY controls the intracellular...

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of...

Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis...

Cathepsin B is a lysosomal cysteine protease. It is implicated in playing a role in protein degradation, arthritis, apoptosis, and cancer.7580 | Active Cathepsin B human recombinant...

Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein...

Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is...

D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker...

EIF2AK3 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3), also known as PERK, is a metabolic-stress sensing protein kinase that phosphorylates and inactivates the alpha subunit of...

Active EphB2 (Fc Tag), Human Recombinant | P1741Description: Ephrin Type-B Receptor 2 (EphB2) is a transmembrane receptor tyrosine kinase glycoprotein that functions through bidirectional signaling...

Fibroblast growth factor binding protein 1 (FGF-BP-1) is a secreted glycoprotein, which contains both a heparin-binding domain and a distinct FGF-binding region, that is shed into circulation where...

GPR15L is a newly identified ligand for GPR15, a member of the G protein-coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15-expressing T cells and...

As a positive control in GST activity assay or for screening GST inhibitors. Refer to the GST Fluorometric and Colorimetric Assay Kits for detailed assay procedures (Cat.# K260-100, K263-100).1243 |...

HIV-2 Protease, an aspartyl protease (retropepsin), is essential for the life-cycle of HIV-2 sub-type virus. It is expressed in the infected cells as a part of Gag-Pol polyprotein from which it is...

HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV. HIV protease cleaves newly synthesized viral polyproteins at the appropriate places into...

Human rhinovirus (HRV) infections are the most frequent causative agents of common cold and various other upper respiratory tract infections. Rhinoviruses are members of the picornavirus family,...

Ca²-dependent cysteine proteinase with low Ca²requirement (half maximal activation = 2 µM). Participates in the ATP release reaction of platelets stimulated with thrombin. Involves in apoptosis...

The caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II...

Caspases are known to play an important role in apoptosis. Caspases exist in cells as inactive pro-enzymes and mature by proteolysis to yield large and small subunits. Active caspases are...

Caspases are known to play an important role in apoptosis. Caspases exist in cells as inactive pro-enzymes. Most of the pro-caspases are matured by proteolysis to yield large and small subunits...

Highly active recombinant human caspases were expressed in E. coli and purified. Active recombinant caspases are useful in screening caspase inhibitors, studying enzyme kinetics and regulation,...

Active recombinant caspases are useful in screening caspase inhibitors, studying enzyme kinetics, determining substrate specificity, and as a positive control in caspase activity assays.K233 | Active...

Active LAMP2/CD107b, Human Recombinant | P1740Description: LAMP2 (CD107b) is a membrane glycoprotein that functions in the protection, maintenance, and adhesion of the lysosome. LAMP2 plays an...

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific...

Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological...

Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive...

The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression,...

-Secretase, also called BACE1 (-site of APP cleaving enzyme) or memapsin-2 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths...

CA12, also known as Carbonic anhydrase 12, is an enzyme that in humans is encoded by the CA12 gene. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible...

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the...

Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular...

Sirtuins function as intracellular regulatory proteins. Human Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include...

Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56...

Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56...

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the...

Active SLAMF6/Ly108, Human Recombinant | P1738Description: SLAMF6 (also known as Ly108) is a transmembrane protein expressed on natural killer (NK), T-, and B-lymphocytes. SLAMF6 undergoes tyrosine...

Recombinant Human Sonic Hedgehog (SHH) is a highly conserved protein that plays an important role in embryonic development. It is expressed in neural tissue, the gut, and areas of limb development...

Recombinant Mouse Sonic Hedgehog is a member of a small group of secreted proteins that are essential for development in both vertebrates and invertebrates. Three mammalian hedgehog genes (sonic,...

Active Syndecan-2/SDC2, Human Recombinant | P1739Description: Syndecan-2 (SDC2) is a transmembrane heparan saulfate proteoglycan that mediates cell binding, cell signaling, and cytoskeletal...

Tissue transglutaminase, a 78-kDa calcium dependent enzyme (EC 2.3.2.13), is found both in the intracellular and the extracellular spaces of various types of tissues. TG2 crosslinks proteins between...

The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the...

Activin A human Elisa Kit | K4769

Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD...

Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD...

Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD...

Activin B is a TGF- family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion...

6284 | ACTL6A Antibody DataSheet

6284BP | ACTL6A Blocking Peptide DataSheetAntibody Target: ACTL6A Accession #: O96019Gene ID: 86Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

ACY-1215 is a potent, cell-permeable and selective inhibitor of histone deacetylase 6 (HDAC6) (IC₅₀ = 5 nM). ACY-1215 is 12-, 10-, 11 and 21-fold less active against HDAC1, HDAC2, HDAC3 and HDAC8,...

ACY-775 is a potent and selective HDAC6 inhibitor (IC₅₀ = 7.5 nM). Displays antidepressant-like properties.ACY-775 is a potent and selective HDAC6 inhibitor (IC₅₀ = 7.5 nM). Displays...

Acyclovir is an antiviral agent with activity against herpesvirus types 1 and 2 and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate) that inhibits...

Adalimumab Humira Human Elisa Kit | K4253

ADAM10 (Human) ELISA Kit | E5103-100Description: ADAM10 is a member of the ADAM (a disintegrin and metalloproteinase) gene family and have been implicated in a variety of biological processes...

3201 | ADAM10 Antibody DataSheet

ADAM17 (Human) ELISA Kit | E5105-100Description: ADAM17 is a member of the ADAM (a disintegrin and metalloproteinase) gene family and is involved in many pathological processes such as cancer,...

ADAM28 (Human) ELISA Kit | E5101-100Description: ADAM28 is a member of the ADAM (a disintegrin and metalloproteinase) gene family and have been implicated in a variety of biological processes...

ADAM29 (Human) ELISA Kit | E5106-100Description: ADAM29 is a member of the ADAM (a disintegrin and metalloproteinase) gene family which is involved in many important physiological processes such as...

ADAM33 (Human) ELISA Kit | E5102-100Description: ADAM33 is a member of the ADAM (a disintegrin and metalloproteinase) gene family and have been implicated in a variety of biological processes...

ADAM9 (Human) ELISA Kit | E5104-100Description: ADAM9 is a member of the ADAM (a disintegrin and metalloproteinase) gene family and have been implicated in a variety of biological processes involving...

ADAMTS1 (Human) ELISA Kit | E5110-100Description: ADAMTS1, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family which plays an important role in various...

ADAMTS12 (Human) ELISA Kit | E5109-100Description: ADAMTS12 is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family which plays an important role in various...

ADAMTS18 (Human) ELISA Kit | E5107-100Description: ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are secreted metalloproteinases that are known for their crucial role in...

ADAMTS20 (Human) ELISA Kit | E5108-100Description: ADAMTS20 (A disintegrin-like and metalloprotease domain with thrombospondin type-1 motifs) is a member of a family of secreted metalloproteases that...

ADAMTS6 (Human) ELISA Kit | E5111-100Description: ADAMTS6 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family which plays an important role in various...

Adapalene is a synthetic Retinoic acid analog that acts as a RARβ and RARγ agonist (AC₅₀ values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits...

Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM) that displays anti-proliferative activity in leukemia models, human prostate cancer cell line PC-3 and other cancer cell lines...

Adaptaquin is a brain-permeable hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) inhibitor. It stabilizes HIF-1α protein and induces expression of the HIF-1-regulated genes EPO and VEGF in...

Adavivint is a potent and selective Wnt pathway inhibitor with an EC₅₀ of 3 nM in vitro; induces hMSC differentiation into mature, functional chondrocytes and decreases cartilage catabolic marker...

K1303 | Adeno-associated Virus Maxi Purification Kit DataSheet

K1311 | Adeno-associated Virus Maxi Purification Kit all serotypes DataSheet

K1302 | Adeno-associated Virus Mini Purification Kit DataSheet

K1304 | Adeno-associated Virus Mini Purification Kit all serotypes DataSheet

6652 | Adenosine Antibody DataSheet

K327 | Adenosine Assay Kit Fluorometric DataSheet

K321 | Adenosine Deaminase Activity Assay Kit Colorimetric DataSheet

K328 | Adenosine Deaminase Activity Assay Kit Fluorometric DataSheet

K993 | Adenosine Deaminase ADA1 Inhibitor Screening Kit Colorimetric DataSheet

Adenosine kinase, also known as ADK is an abundant enzyme in mammalian tissues that catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of...

Adenosine is a purine nucleoside that serves as an endogenous ligand of a family of four adenosine receptors, which serve diverse roles related to smooth muscle tone, central nervous system...

K807 | Adenosylhomocysteinase AHCY Activity Fluorometric Assay Kit DataSheet