26

7009 | Alpha1 Antitrypsin Antibody DataSheet

Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ =35 nM). Also inhibits CDK2/cyclin A, CDK2/cyclin E (IC₅₀ = 200 nM), CDK5/p25 (IC₅₀ = 40 nM), CDK5/p35 (IC₅₀ = 40 nM) and GSK-3β...

Sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light...

Altiratinib is a selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. It effectively reduces tumor burden in vivo and blocks c-MET...

Altretamine is an alkylating agent with antineoplastic and antiproliferative activity. It also acts as a chemosterilant for male houseflies and other insects.Altretamine is an alkylating agent with...

Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the pIC50 of 7.9 for Human NE.Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the...

Alvimopan is a peripherally acting μ-opioid receptor antagonist (Ki = 0.47 nM) that is selective over the κ- and δ-opioid receptors (Ki's = 100 nM and 12 nM, respectively). It is used to avoid...

AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibits LPA-driven chemotaxis of CHO...

AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibitsLPA-driven chemotaxis of CHO...

AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. It also acts as an agonist at GPR55 (EC50 = 39 nM) and potentiates GABAA receptor currents (EC50 = 0.4 µM). In mice,...

AM-679 is a potent 5-lipoxygenase-activating protein (FLAP) inhibitor with IC₅₀s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.AM-679 is a potent 5-lipoxygenase-activating protein...

AM-92016 hydrochloride is a specific inhibitor of delayed rectifier potassium current. In guinea-pig and rabbit ventricular cells, AM 92016 significantly increased action potential duration with 20%...

AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM)...

Amastatin is an inhibitor of aminopeptidase A and leucine aminopeptidase (IC₅₀ values of 0.54 μg/ml and 0.5 μg/ml). It does not show any significant inhibition of aminopeptidase B, trypsin,...

Ambroxol is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive...

AMG-708 is a selective small-molecule inhibitor (IC₅₀ = 9.3 nM) of the proto-oncogene c-Met with potential antineoplastic activity. AMG 208 inhibits the ligand-dependent and ligand-independent...

AMG232 is a highly potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC₅₀ = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft...

AMG-337 is a potent and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, that subsequently blocks downstream PI3K and MAPK pathways. It has been...

AMG-47a is a potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED₅₀ = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. In several other in vitro...

AMG-510 is an orally available agent that targets the specific KRAS mutation, p.G12C, with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively...

AMG-517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1) with an IC₅₀ of 0.9 nM. It inhibits post-burn mechanical and thermal allodynia in a rat model of burn injury when...

AMG-900 is a highly sensitive and orally bioavailable inhibitor of Aurora Kinase with IC50 values of 5 nmol/LAMG-900 is a highly sensitive and orally bioavailable inhibitor of Aurora Kinase with IC50...

AMG-925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC₅₀ of 1 nM and 3 nM, respectively. It inhibits the proliferation of a panel of human tumor cell lines including Colo205...

AMG-Tie2 is a highly potent, non-selective inhibitor of Tie-2AMG-Tie2 is a highly potent, non-selective inhibitor of Tie-2B1612 | AMG-Tie2 DataSheetAlternate Name/Synonyms: AMGTie2; AMG Tie2;...

AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, also inhibits PI3Kγ with IC50 of 850 nM.AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, also inhibits PI3Kγ...

Cell-permeable. A potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor (IC₅₀ = 8.8 μM for human PRMT1 and 3.0 μM for yeast Hmt1p ). Does not compete for the AdoMet...

AMI-5 is a non-specific small molecule inhibitor of protein arginine methyltransferases (PRMTs) (IC₅₀ = 0.78 and 1.41 µM against Hmt1p and PRMT1, respectively) and histone lysine methyltransferases...

A diacylglycerol acyltransferase (DGAT) inhibitor. Shows inhibitory effect in rat liver microsomes (IC₅₀ = 10.2 µM) and Raji cells (IC₅₀ = 15.5 µM). Excessive accumulation of triacetylglycerol...

An inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC₅₀ = 17.5 µM) and Raji cells (IC₅₀ = 2.8µM). Excessive accumulation of triacetylglycerol...

Cell-permeable. A broad spectrum radio- and chemoprotective agent. Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.Amifostine...

Semisynthetic, aminoglycoside antibiotic derived from Kanamycin A. Range of activity is similar to Gentamicin. Active against many strains of Gram negative bacteria. Amikacin prevents bacterial...

Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and...

K523 | Aminopeptidase N APN/CD13 Activity Assay Kit Fluorometric DataSheet

A cell-permeable, reversible and competitive inhibitor of cyclin-dependent kinases. IC₅₀ values are: CDK1/cyclin B (33 nM), CDK2/cyclin A (33 nM), CDK2/cyclin E (28 nM) and CDK5/p35 (20 nM)...

A non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death...

Amiselimod (MT1303), is a potent and selective immunosuppressant and sphingosine 1 phosphate 1 (S1P1) receptor modulator. Amiselimod may be potentially useful for treatment of multiple sclerosis,...

An anti-allergy, anti-asthma and anti-diabetic agent. Improves obesity-related metabolic dysfunction in mouse models. Increases thermogenesis and weight loss, decreases steatosis and improves insulin...

A L-type calcium channel blocker and an anti-hypertensive agent. Amlodipine displays vasoprotective effects in cardiovascular disease and inhibits Ca²⁺-induced contractions in depolarized rat aorta...

AMMC iodide is a useful substrate for the human cytochrome P450 CYP2D6 isozyme. It is demethylated to the fluorescent product 3-[2-(N,N-diethyl-N-methyl ammonium)ethyl]-7-hydroxy-4-methylcoumarin...

K370 | Ammonia Colorimetric Assay Kit DataSheet

K470 | Ammonia Colorimetric Assay Kit II DataSheet

Protein solubility is dependent on the ionic strength of the solution, among other factors. Two distinct phenomenon of protein solubilization are seen in general: 1) Salting in: At low salt...

E4614 | Amoxicillin Elisa Kit DataSheet

Amoxicillin is an orally bioavailable, semisynthetic, broad-spectrum β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of...

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the...

A polyene antifungal antibiotic from Streptomyces. Amphotericin B targets a wide range of susceptible fungi including Histoplasma, Coccidioides, and Cryptococcus species. Amphotericin B targets...

E4350 | Ampicillin Elisa Kit DataSheet

Ampicillin sodium is a β-lactam antibiotic structurally related to penicillin. Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell...

A β-lactam antibiotic structurally related to penicillin. Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Ampicillin can be...

Cell-permeable. A potent activator of AMPK (AMP-activated protein kinase). The activation of AMPK was achieved through inhibition of NAD(P)H dehydrogenase [quinone] 1 (complex I). D942 increases...

3951BP | AMPK Blocking Peptide DataSheetAntibody Target: AMPK Accession #: NP_006242.5Gene ID: 5562Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

E4280 | AMPK Human Elisa Kit DataSheet

AMPK1 Antibody | 3112

3109 | AMPK? Antibody DataSheet

3110 | AMPK?1 Antibody DataSheet

3117 | AMPK?2 Antibody DataSheet

Amprenavir is the active metabolite of the pro-drug fosamprenavir. It acts as an antiretroviral HIV Protease Inhibitor. When used alone or in combination therapy with other antiretroviral agents,...

Amrinone is a potent phosphodiesterase 3 (PDE3) inhibitor (IC₅₀ = 19.5 µM). It increases developed tension and contractile force in isolated cat papillary muscle. It also displays positive inotropic...

Amsacrine is a potent DNA intercalating and an antineoplastic agent. One of the ways amsacrine works is by blocking an enzyme topoisomerase 2. It is effective in the treatment of acute leukemias and...

AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the...

Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC₅₀ values of 10 nM, 40 nM and 81 nM, respectively. It also disrupts DNA repair likely through suppression...

Amygdalin is a cyanogenic glucoside isolated from almonds and seeds of other plants of the family Rosaceae. It displays anticancer and anti-inflammatory properties. It induces apoptosis as a result...

K711 | Amylase Activity Colorimetric Assay Kit DataSheet

E4288 | Amyloid Beta 42 Human Elisa Kit DataSheet

AMZ30 is a potent, selective, and covalent inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living...

AN-2728 is a boron-based, topical anti-inflammatory agent that acts as a phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC₅₀s = 6.12, 6.41,...

ANA-12 is a potent and selective TrkB antagonist that prevents activation of the receptor by BDNF with a high potency. It binds selectively to TrkB and inhibits processes downstream of TrkB without...

Cell-permeable. A potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC₅₀~8.5 µM and ~5 µM, respectively. Inhibits SUMOylation...

Anacetrapib is a potent inhibitor of the cholesteryl ester transfer protein (CETP)-dependent transfer of cholesteryl ester (CE) (IC₅₀ = 17 ± 4.8 nM); it significantly raises HDL cholesterol levels in...

Anagrelide is a phosphodiesterase 3 (PDE3) inhibitor (IC₅₀ = 36 nM) with antiplatelet activity. Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte...

Anastrozole is a potent aromatase inhibitor that has been shown to effectively eliminate the conversion of androgens to estrogens in peripheral tissues. It inhibits human placental aromatase in vitro...

A protein farnesyl transferase inhibitor. Displays antitumor properties. Inhibits the efflux of anticancer drugs from multidrug-resistant cancer cells.Andrastin A, Aspergillus fumigatus is a protein...

6711 | Androgen Receptor Antibody (Clone 549CT16.1.4) DataSheet

A major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo. Prevents...

Androsterone ELISA Kit | E5112-100Description: Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. An androgen is any natural or...

Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells. Ang-1/ Tie-2 signaling promotes...

ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending...

K905 | Angiogenesis Tube Formation Assay DataSheet

Angiopoietin-1 human Elisa Kit | K7115

Angiopoietin-2 human Elisa Kit | K7116

Angiostatin human Elisa Kit | K4755

Angiostatin is a proteolytic fragment of plasminogen constituting kringles 1 - 4. It is a potent angiogenesis inhibitor and the inhibition of angiogenesis by angiostatin is directly related to...

Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific...

K228 | Angiotensin I Converting Enzyme ACE1 Inhibitor Screening Kit DataSheet

K227 | Angiotensin I Converting Enzyme Activity ACE1 Assay Kit Fluorometric DataSheet

E4515 | Angiotensin I Human Elisa Kit DataSheet

E4527 | Angiotensin II Ang II Human Elisa Kit DataSheet

K897 | Angiotensin II Converting Enzyme ACE2 Activity Assay Kit Fluorometric DataSheet

K310 | Angiotensin II Converting Enzyme ACE2 Inhibitor Screening Kit DataSheet

The octapeptide angiotensin II exerts a wide range of effects on the cardioVascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Angiotensin II is...

E4536 | Angiotensin III Ang III Human Elisa Kit DataSheet

6760 | ANGPT1 Antibody (CT) DataSheet

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It...

6761 | ANGPTL1 Antibody (NT) DataSheet

K4914 | ANGPTL3 human Serum Elisa Kit DataSheet

K4915 | ANGPTL3 mouse/rat Serum Elisa Kit DataSheet

K4916 | ANGPTL6 human Serum Elisa Kit DataSheet

Anidulafungin is an echinocandin antifungal drug. It inhibits (1→3)-β-D-glucan synthase which is required for synthesis of the fungal cell wall. It shows potent in vitro activity against Aspergillus...

An activator of p54 and MAP kinases. Synergistic with growth factors and phorbol esters to superinduce cFas and c-Jun, by acting as a potent signaling agonist. Induces apoptosis in the human...

Anlotinib (AL3818) is a potent oral receptor tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR2) and 3 (VEGFR3), fibroblast growth factor 1–4, platelet-derived...