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K4158 | 3-Nitrotyrosine Elisa Kit DataSheet

A potent SIRT3 inhibitor (IC₅₀ = 16 nM). Displays selectivity over SIRT1 (IC₅₀ = 88 nM) and SIRT2 (IC₅₀ = 92 nM).3-TYP is a potent SIRT3 inhibitor (IC₅₀ = 16 nM). Displays selectivity over SIRT1...

K948 | 3D Cell Culture HTS Cell Viability Complete Assay Kit DataSheet

K517 | 3D Cell Culture Matrix Alginate Hydrogel Kit DataSheet

K518 | 3D Cell Culture Matrix BME Kit DataSheet

K519 | 3D Cell Culture Matrix Duo-Matrix Kit DataSheet

K982 | 3D Cell Culture Non-Enzymatic Cell Harvesting Kit DataSheet

K990 | 3D Cell Culture Ready-to-Use Scaffold Complete Kit DataSheet

3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be a useful agent in combination with other drugs...

K579 | 3T3-L1 Differentiation Kit DataSheet

's loading Buffer (3X) which is also called Laemmli Sample Buffer, is a ready-to-use buffer solution for the preparation of protein samples to be separated in SDS-polyacrylamide gel electrophoresis...

4'-Hydroxy chalcone is a chalcone metabolite with diverse biological activities. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner. Also known to activate...

5369 | 4-1BBL Antibody DataSheet

Human 4-1BB Ligand (4-1BBL) is a member of the emerging family of Ligands with structural homology to tumor necrosis factor. Recombinant human 4-1BBL is a 19.5 kDa protein containing 185 amino acid...

5370 | 4-1BBR Antibody DataSheet

Human 4-1BB Receptor (4-1BBR) is an inhibitor of 4-1BBL and can block 4-1BBL bioactivity. Recombinant human 4-1BBR is a 17.8 kDa protein containing 167 amino acid residues of extraCellular domain of...

4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is a useful ligand in affinity chromatography for...

4-Aminonaphthalimide is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 180 nM. It inhibits radiation-induced PARP in cancer cells, potentiating the cytotoxicity...

4-CPPC is a potent, reversible and selective small molecule inhibitor of the pro-inflammatory protein macrophage migration inhibitory factor-2 (a.k.a. MIF-2 or D-DT) (IC50 = 27 µM). 4-CPPC...

E4645 | 4-Hydroxynonenal 4-HNE Elisa Kit DataSheet

4-hydroxynonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-HNE is widely used as a marker of lipid peroxidation. It exhibits...

4-Hydroxyquinazoline is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 9.5 μM. 4-hydroxyquinazoline improves the recovery of high-energy phosphates (ATP,...

4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase...

4-Methylumbelliferyl-alpha-D-galactopyranoside is a useful substrate for the fluorogenic assay of α-D-galactosidase.4-Methylumbelliferyl-alpha-D-galactopyranoside is a useful substrate for the...

4-Methylumbelliferyl-alpha-D-glucopyranoside is a useful fluorogenic substrate for alpha-D-glucosidase.4-Methylumbelliferyl-alpha-D-glucopyranoside is a useful fluorogenic substrate for...

4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase.4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase.B1806 |...

4-Octyl itaconate is an endogenous metabolite of itaconate that activates the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by lipopolysaccharide in mouse and human macrophages...

4-pentynoyl-Coenzyme A (trifluoroacetate salt) is an alkyne-derivatized acetyl-CoA reporter. It is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. It enables...

The mammalian small ribosomal subunit (40S) is the smaller subunit of the mammalian 80S ribosomes, with the other major component being the large ribosomal subunit (60S). The 40S subunit consists of...

4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11...

4SC-202 is an orally available potent HDAC inhibitor (HDACi) specific for class I HDAC isoenzymes with IC50s of 1.2/1.12/0.57 µM for HDAC1/2/3; displays high selectivity over ClassIIa/IIb/III HDACs...

4µ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ = 60 nM). It blocks substrate access to the active site of IRE1α and inactivates IRE1α-mediated mRNA degradation. Displays...

An epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and...

A potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to...

5-Bromo-4-chloro-3-indolyl N-acetyl-β-D-glucosaminide is a histochemical substrate for N-Acetylglucosaminidase. It releases an insoluble blue chromophore after enzymatic action...

5-CFDA is a non-fluorescent, hydrophobic cell-permeable, vital stain. Once inside the cells, 5-CFDA is hydrolyzed by intracellular esterases to highly fluorescent 5-carboxyfluorescein (5-CF).5-CFDA...

A novel agent for fast and sensitive detection of DNA synthesis in vivo. 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click ligation. In...

5-Fluoroorotic Acid (5-FOA) is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate (OMP) decarboxylase. 5-FOA is toxic to yeast cells that...

5-Fluorouracil (5-FU) is an anticancer agent that gets metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits...

5-Fluorouridine is a ribonucleotide metabolite of 5-Fluorouracil. It is cytotoxic and inhibits rRNA synthesis in human colon carcinoma cells. It exhibits cytotoxic effect on lymphoma cells with an...

6830 | 5-hmC polyclonal antibody (rabbit) DataSheet

E4533 | 5-Hydroxyindoleacetic Acid 5-HIAA Elisa Kit DataSheet

A1059 | 5-Hydroxytryptamine Receptor 1A Antibody DataSheet

5-Iodotubercidin is a potent adenosine kinase inhibitor (IC₅₀ = 26 nM). 5-Iodotubercidin initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation...

K980 | 5-Lipoxygenase Inhibitor Screening Kit Fluorometric DataSheet

Lipoxygenases are non-heme iron-containing dioxygenases. These enzymes convert unsaturated fatty acids to epoxides, such as leukotrienes from arachidonic acid. They play an important role in cell...

5-LO Inhibitor, CDC | B3341Description: CDC is a potent and direct inhibitor of 5-LO (5-lipoxygenase). CDC reduces 5-LO activity in cell-free assays (purified human recombinant enzyme or leukocyte...

5-Methylcytidine is useful in Epigenetics research especially in studies involving DNA methylation processes.5-Methylcytidine is useful in Epigenetics research especially in studies involving DNA...

5-Methylcytosine is useful in Epigenetics research especially in studies involving DNA methylation processes.5-Methylcytosine is useful in Epigenetics research especially in studies involving DNA...

5-Nitroso-8-quinolinol is a quinoline inhibitor of histone deacetylase (HDAC). It inhibits HDAC activity in vitro and causes reactive oxygen species, DNA damage and apoptosis in MCF-7 breast cancer...

K992 | 5’-Nucleotidase Activity Assay Kit Colorimetric DataSheet

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. Acts as a potent agonist of...

Polypropylene columns are contact-transparent, more chemically-resistant and appropriate for use with organic solvents and stronger acids (except oxidizing acids) and alkalis. These columns are for...

6-aminonicotinamide (6-AN) is inhibitor of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the conversion of G-6-P to 6-phosphogluconolactone, the first step of the pentose phosphate...

6-Azauridine is a synthetic triazine analog of uridine with antimetabolite activity. 6-Azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono,...

6-Bromoisatin (6Br) acts as a chemopreventive compound. 6Br was found to be an effective chemo-preventative compound when orally administered in a 14-week colorectal cancer model.6-Bromoisatin (6Br)...

6-CFDA has been used to differentiate viable cells from apoptotic cells. Live cells that are not apoptotic accumulate 6-carboxyfluorescein but do not accumulate annexin. CFDA enters cells and is...

Bioactive compound found in ginger (Zingiber officinale). Displays antioxidant, anti-inflammatory and antitumor properties. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages...

6-Mercaptopurine is an inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. An immunosuppressive and antileukemic agent. 6-Mercaptopurine is an inhibitor of de novo...

K540 | 6-Phosphogluconate Dehydrogenase Activity Colorimetric Assay Kit DataSheet

K217 | 6-Phosphogluconic Acid 6-PGA Assay Kit Colorimetric DataSheet

The mammalian large ribosomal subunit (60S) is the larger subunit of the mammalian 80S ribosomes, with the other major component being the small ribosomal subunit (40S). The 60S subunit consists of a...

666-15 is a potent and selective inhibitor of cyclic adenosine monophosphate response element binding protein (CREB)-mediated gene transcription with an IC₅₀ of 81 nM. The IC₅₀ values for inhibiting...

Cell-permeable. A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO, Ki = 51 nM.) Tryptophan is metabolized to the endogenous AHR ligand by TDO which may be inhibited by 680C91...

6877002 is a CD40-TRAF6 interaction inhibitor compound that specifically targets TNF receptor-associated factor 6 (TRAF6; Kd = 97 µM for TRAF6 C-domain) and disrupts its functional coupling with CD40...

An ATP-competitive inhibitor of Cot and MKK4 that subsequently suppresses UVB-induced COX-2 expression in JB6 P+ mouse epidermal cells.7,3',4'-Trihydroxyisoflavonem is an ATP-competitive inhibitor of...

A useful Fluorescent labeling reagent for trace determination of enzymes. Also useful as a reference standard in enzyme assays7-Amino-4-methylcoumarin is a useful Fluorescent labeling reagent for...

7-Aminoactinomycin D (7-AAD) is a fluorescent dye that undergoes a spectral shift upon association with DNA. It distinguishes viable, apoptotic, and late apoptotic/dead cells in flow cytometry. It...

6655 | 7-Methylguanosine Antibody DataSheet

A non-selective, reversible and competitive inhibitor of NOS isoforms in vitro. The IC₅₀ values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 µM, respectively...

7BIO is a caspase- independent nonapoptotic cell death inducer. Also acts as an ATP-competitive FLT3 inhibitor and DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated kinase)...

Polypropylene columns are contact-transparent, more chemically-resistant and appropriate for use with organic solvents and stronger acids (except oxidizing acids) and alkalis. These columns are for...

8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells...

A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and...

A cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase (PKG), slows or inhibits the intracellular calcium...

K4160 | 8-hydroxy-2'-deoxyguanosine 8-OHdG Elisa Kit DataSheet

8-Hydroxy-2-deoxyguanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a critical biomarker of oxidative...

8-Hydroxyguanosine is produced by oxidative damage of RNA. Serves as useful marker for measuring the rate of oxidative damage to nucleic acids and lipids.8-Hydroxyguanosine is produced by oxidative...

E4632 | 8-oxoguanine DNA glycosylase OGG1 Human Elisa Kit DataSheet

8-Prenylnarinegin | B3344Description: 8-Prenylnaringenin (8-PN) is a non-steroidal phytoestrogen from Hops that mimicks endogenous estrogens via estrogen receptor binding. Inhibits both isoforms of...

9-cis Retinoic acid is an agonist at retinoic acid receptors (RARs) and retinoic X receptors (RXRs). 9-cis Retinoic acid also inhibits adipogenesis. In lymphatic endothelial cells, 9-cis retinoic...

The 96 Well Half-Area Microplates are black polystyrene plates with a flat bottom and 96 round wells. These plates have a total well volume of 190 μl and are used to save on expensive reagents by...

These are polystyrene microplates (solid black) with standard solid flat bottom, chimney well. The flat bottom allows precise optics and the rounded corners allow pipetting without leaving a residue...

These are polystyrene TC-treated, sterile, black microplates with flat, clear bottom. The white wall enhances the luminescent signal and leads to low background luminescence and fluorescence. The...

These are polystyrene plates with clear C-bottom single-break strips provided as twelve 8-well strips in a support frame (12 x 8 matrix). The individual wells can be broken off separately...

These are 96 well clear well UV microplate that has a UV-transparent well bottom and is ideal for determining protein and/or nucleic acid concentrations.M1360 | 96-Well Clear UV Transparent Plates...

K1325 | 96-well Plasmid ezFilter Mini Kit DataSheet

These are polystyrene plates with clear C-bottom single-break strips provided as twelve 8-well strips in a support frame (12 x 8 matrix). The individual wells can be broken off separately...

K1417 | 96-well Viral DNA/RNA Kit DataSheet

These are polystyrene microplates (white) with standard solid flat bottom, chimney well. The flat bottom allows precise optics and the rounded corners allow pipetting without leaving a residue.M1354...

These are polystyrene TC-treated, sterile, microplates (white) with flat clear bottom. The white wall enhances the luminescent signal and leads to low background luminescence and fluorescence. The...

A selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC₅₀ values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation...

A-1155463 is a highly potent and selective BCL-XL inhibitor. A-1155463 is more potent against BCL-XL-dependent cell lines relative to WEHI-539 (Cat. No. B1819), while possessing none of its inherent...

A-1210477 is a potent MCL-1 inhibitor (Ki = 0.45 nM in TR-FRET-binding assays). Acts as a weak inhibitor of BCL-2 (Ki = 0.132 μM) and BCL-XL(Ki>0.660 μM).A-1210477 is a potent MCL-1 inhibitor (Ki = 0...

A-1331852 is a potent anti-apoptotic Bcl-xL protein inhibitor and apoptosis-inducing agent useful in the treatment of cancer, immune and autoimmune diseases.A-1331852 is a potent anti-apoptotic...

A-196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Displays 100-fold selectivity over other histone methyltransferases and non-epigenetic targets...

A Brominated analog of A-23187 (Cat. No. 1501-10). A nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes.A-23187, 4-Bromo-,...

A-317491 | B3367Description: A-317491 is a selective non-nucleotide antagonist of P2X3 and P2X2/3 receptor activation. A-317491 potently blocks recombinant human and rat P2X3 and P2X2/3...

A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been...

A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM). Also acts as a DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1...